Regulation of Wing Hair Morphogenesis by Trc and Fry in Drosophila Melanogaster

2008 ◽  
Author(s):  
Xiaolan Fang
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Hair ◽  
Hair Morphogenesis

The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis

1994 ◽  
Vol 46 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Paul N. Adler ◽  
Jeannette Charlton ◽  
Katherine H. Jones ◽  
Jingchun Liu
Keyword(s):  
Sensitive Period ◽  
Wing Hair ◽  
Cold Sensitive ◽  
Hair Morphogenesis

scholarly journals Actin Filament Bundles in Drosophila Wing Hairs: Hairs and Bristles Use Different Strategies for Assembly

2005 ◽  
Vol 16 (8) ◽  
pp. 3620-3631 ◽  
Author(s):  
Gregory M. Guild ◽  
Patricia S. Connelly ◽  
Linda Ruggiero ◽  
Kelly A. Vranich ◽  
Lewis G. Tilney
Keyword(s):  
Actin Filament ◽  
Two Dimensions ◽  
Raw Material ◽  
Wing Hair ◽  
Distal Side ◽  
High Resolution Analysis ◽  
Filament Bundles ◽  
Resolution Analysis ◽  
Cross Bridges ◽  
Hair Morphogenesis

Actin filament bundles can shape cellular extensions into dramatically different forms. We examined cytoskeleton formation during wing hair morphogenesis using both confocal and electron microscopy. Hairs elongate with linear kinetics (∼1 μm/h) over the course of ∼18 h. The resulting structure is vividly asymmetric and shaped like a rose thorn—elongated in the distal direction, curved in two dimensions with an oval base and a round tip. High-resolution analysis shows that the cytoskeleton forms from microvilli-like pimples that project actin filaments into the cytoplasm. These filaments become cross-linked into bundles by the sequential use of three cross-bridges: villin, forked and fascin. Genetic loss of each cross-bridge affects cell shape. Filament bundles associate together, with no lateral membrane attachments, into a cone of overlapping bundles that matures into an oval base by the asymmetric addition of bundles on the distal side. In contrast, the long bristle cell extension is supported by equally long (up to 400 μm) filament bundles assembled together by end-to-end grafting of shorter modules. Thus, bristle and hair cells use microvilli and cross-bridges to generate the common raw material of actin filament bundles but employ different strategies to assemble these into vastly different shapes.

scholarly journals The Drosophila tissue polarity gene inturned functions prior to wing hair morphogenesis in the regulation of hair polarity and number.

Genetics ◽  
1994 ◽  
Vol 137 (3) ◽  
pp. 829-836 ◽  
Author(s):  
P N Adler ◽  
J Charlton ◽  
W J Park
Keyword(s):  
Temperature Shift ◽  
Null Alleles ◽  
Cold Sensitivity ◽  
Sensitive Period ◽  
Temperature Sensitive ◽  
Heat Sensitivity ◽  
Permissive Temperature ◽  
Wing Hair ◽  
Almost All ◽  
Hair Morphogenesis

Abstract The adult cuticular wing of Drosophila is covered with an array of distally pointing hairs. Mutations in the inturned (in) gene result in both abnormal hair polarity (i.e., hairs no longer point distally), and, in most cells forming more than one hair. We have isolated and characterized a collection of in alleles. Among this collection of alleles are a number of rearrangements that enable us to assign in to 77B3-5. Almost all of the in alleles, including putative null alleles, result in a stronger phenotype on the wing at 18 degrees than 29 degrees. The data argue that the in-dependent process is cold-sensitive. Temperature shift experiments with a hypomorphic allele show that this cold sensitivity can be relieved by several hours of incubation at the permissive temperature at a variety of times in the early pupae, but that this ability ends prior to the start of hair morphogenesis. One new allele showed a dramatic heat sensitivity. Temperature shift experiments with this allele revealed a very short temperature-sensitive period that is a few hours prior to the start of hair morphogenesis. That the temperature during hair morphogenesis is irrelevant for the phenotype of in is consistent with the hypothesis that the only role that in has in wing hair development is to regulate the initiation of hair morphogenesis.

scholarly journals The shavenoid Gene of Drosophila Encodes a Novel Actin Cytoskeleton Interacting Protein That Promotes Wing Hair Morphogenesis

Genetics ◽  
2005 ◽  
Vol 172 (3) ◽  
pp. 1643-1653 ◽  
Author(s):  
Nan Ren ◽  
Biao He ◽  
David Stone ◽  
Sreenatha Kirakodu ◽  
Paul N. Adler
Keyword(s):  
Actin Cytoskeleton ◽  
Interacting Protein ◽  
Wing Hair ◽  
Hair Morphogenesis

Author response for "Location and arrangement of campaniform sensilla in Drosophila melanogaster"

2020 ◽  
Author(s):  
Gesa F. Dinges ◽  
Alexander S. Chockley ◽  
Till Bockemühl ◽  
Kei Ito ◽  
Alexander Blanke ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Author Response ◽  
Campaniform Sensilla

Live Confocal Analysis of Fertilization and Early Development

2001 ◽  
Vol 7 (S2) ◽  
pp. 1012-1013
Author(s):  
Uyen Tram ◽  
William Sullivan
Keyword(s):  
Drosophila Melanogaster ◽  
Embryonic Development ◽  
Real Time ◽  
Early Development ◽  
Fluorescent Probes ◽  
Primary Defect ◽  
Fluorescent Analysis ◽  
Dynamic Event ◽  
Enormous Amount ◽  
Fluorescent Studies

Embryonic development is a dynamic event and is best studied in live animals in real time. Much of our knowledge of the early events of embryogenesis, however, comes from immunofluourescent analysis of fixed embryos. While these studies provide an enormous amount of information about the organization of different structures during development, they can give only a static glimpse of a very dynamic event. More recently real-time fluorescent studies of living embryos have become much more routine and have given new insights to how different structures and organelles (chromosomes, centrosomes, cytoskeleton, etc.) are coordinately regulated. This is in large part due to the development of commercially available fluorescent probes, GFP technology, and newly developed sensitive fluorescent microscopes. For example, live confocal fluorescent analysis proved essential in determining the primary defect in mutations that disrupt early nuclear divisions in Drosophila melanogaster. For organisms in which GPF transgenics is not available, fluorescent probes that label DNA, microtubules, and actin are available for microinjection.

Apoptosis and development

2003 ◽  
Vol 39 ◽  
pp. 11-24 ◽  
Author(s):  
Justin V McCarthy
Keyword(s):  
Drosophila Melanogaster ◽  
Mammalian Cells ◽  
Cell Number ◽  
Model Organisms ◽  
Biological Processes ◽  
Nematode Caenorhabditis Elegans ◽  
Apoptotic Pathway ◽  
Genetic Pathways ◽  
Evolutionarily Conserved ◽  
Multicellular Organisms

Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The large diversity of regulators of apoptosis in mammalian cells and their numerous interactions complicate the analysis of their individual functions, particularly in development. The remarkable conservation of apoptotic mechanisms across species has allowed the genetic pathways of apoptosis determined in lower species, such as the nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster, to act as models for understanding the biology of apoptosis in mammalian cells. Though many components of the apoptotic pathway are conserved between species, the use of additional model organisms has revealed several important differences and supports the use of model organisms in deciphering complex biological processes such as apoptosis.

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