scholarly journals Developmental Regression in Autism Spectrum Disorders and the Broad Autism Phenotype

2017 ◽  
Author(s):  
Robert Haxter
Keyword(s):  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Broad Autism Phenotype ◽  
Developmental Regression ◽  
Spectrum Disorders ◽  
Autism Phenotype

scholarly journals The broad autism phenotype predicts child functioning in autism spectrum disorders

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Christina R Maxwell ◽  
Julia Parish-Morris ◽  
Olivia Hsin ◽  
Jennifer C Bush ◽  
Robert T Schultz
Keyword(s):  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Broad Autism Phenotype ◽  
Child Functioning ◽  
Spectrum Disorders ◽  
Autism Phenotype

scholarly journals Tracing Autism Traits in Large Multiplex Families to Identify Endophenotypes of the Broader Autism Phenotype

2020 ◽  
Vol 21 (21) ◽  
pp. 7965
Author(s):  
Krysta J. Trevis ◽  
Natasha J. Brown ◽  
Cherie C. Green ◽  
Paul J. Lockhart ◽  
Tarishi Desai ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Adaptive Functioning ◽  
High Sensitivity ◽  
Broader Autism Phenotype ◽  
Structured Interview ◽  
Autism Spectrum ◽  
Autism Traits ◽  
Multiplex Families ◽  
Spectrum Disorders ◽  
Autism Phenotype

Families comprising many individuals with Autism Spectrum Disorders (ASD) may carry a dominant predisposing mutation. We implemented rigorous phenotyping of the “Broader Autism Phenotype” (BAP) in large multiplex ASD families using a novel endophenotype approach for the identification and characterisation of distinct BAP endophenotypes. We evaluated ASD/BAP features using standardised tests and a semi-structured interview to assess social, intellectual, executive and adaptive functioning in 110 individuals, including two large multiplex families (Family A: 30; Family B: 35) and an independent sample of small families (n = 45). Our protocol identified four distinct psychological endophenotypes of the BAP that were evident across these independent samples, and showed high sensitivity (97%) and specificity (82%) for individuals classified with the BAP. Patterns of inheritance of identified endophenotypes varied between the two large multiplex families, supporting their utility for identifying genes in ASD.

scholarly journals The Broader Autism Phenotype and Its Implications on the Etiology and Treatment of Autism Spectrum Disorders

2011 ◽  
Vol 2011 ◽  
pp. 1-19 ◽  
Author(s):  
Jennifer Gerdts ◽  
Raphael Bernier
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum Disorders ◽  
Communication Skills ◽  
Broader Autism Phenotype ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Common Finding ◽  
High Concordance ◽  
Spectrum Disorders ◽  
Autism Phenotype

The presence of autism-related traits has been well documented in undiagnosed family members of individuals with autism spectrum disorder (ASD). The most common finding is mild impairments in social and communication skills that are similar to those shown by individuals with autism, but exhibited to a lesser degree. Termed thebroader autism phenotype(BAP), these traits suggest a genetic liability for autism-related traits in families. Genetic influence in autism is strong, with identical twins showing high concordance for the diagnosis and related traits and approximately 20% of all ASD cases having an identified genetic mechanism. This paper highlights the studies conducted to date regarding the BAP and considers the implications of these findings for the etiology and treatment of ASD.

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