Lessons in Aging From a Single-celled Eukaryote: Unveiling Mechanisms of Chronological Lifespan Extension in Saccharomyces Cerevisiae

2015 ◽  
Author(s):  
Margaret Wierman
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Lifespan Extension ◽  
Chronological Lifespan

Effects of S-allyl glutathione disulphide and vinyl-dithiin isomers from garlic on the chronological lifespan of Saccharomyces cerevisiae

2017 ◽  
Vol 37 ◽  
pp. 650-657
Author(s):  
Florian Lehnhardt ◽  
Dong Liang ◽  
Qimin Chen ◽  
Restituto Tocmo ◽  
Michael Rychlik ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chronological Lifespan ◽  
Glutathione Disulphide

SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae

2019 ◽  
Vol 83 (8) ◽  
pp. 1473-1476
Author(s):  
Koji Masumura ◽  
Sachi Matsukami ◽  
Kumiko Yonekita ◽  
Muneyoshi Kanai ◽  
Kazunori Kume ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chronological Lifespan

scholarly journals An Optimized Competitive-Aging Method Reveals Gene-Drug Interactions Underlying the Chronological Lifespan of Saccharomyces cerevisiae

2020 ◽  
Vol 11 ◽  
Author(s):  
J. Abraham Avelar-Rivas ◽  
Michelle Munguía-Figueroa ◽  
Alejandro Juárez-Reyes ◽  
Erika Garay ◽  
Sergio E. Campos ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Drug Interactions ◽  
Chronological Lifespan

scholarly journals StimulatingS-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK

2016 ◽  
Vol 113 (42) ◽  
pp. 11913-11918 ◽  
Author(s):  
Takafumi Ogawa ◽  
Ryohei Tsubakiyama ◽  
Muneyoshi Kanai ◽  
Tetsuya Koyama ◽  
Tsutomu Fujii ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Protein Kinase ◽  
Cell Survival ◽  
Metabolic Effects ◽  
Model Organisms ◽  
Lifespan Extension ◽  
Beneficial Effects ◽  
Energy Sensing ◽  
Amp Activated Protein Kinase ◽  
Methionine Synthesis

Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites responsible for DR regimens is not fully understood. Here we show that stimulatingS-adenosyl-l-methionine (AdoMet) synthesis extended the lifespan of the budding yeastSaccharomyces cerevisiae. The AdoMet synthesis-mediated beneficial metabolic effects, which resulted from consuming both Met and ATP, mimicked CR. Indeed, stimulating AdoMet synthesis activated the universal energy-sensing regulator Snf1, which is theS. cerevisiaeortholog of AMP-activated protein kinase (AMPK), resulting in lifespan extension. Furthermore, our findings revealed thatS-adenosyl-l-homocysteine contributed to longevity with a higher accumulation of AdoMet only under the severe CR (0.05% glucose) conditions. Thus, our data uncovered molecular links between Met metabolites and lifespan, suggesting a unique function of AdoMet as a reservoir of Met and ATP for cell survival.

scholarly journals Saccharomyces cerevisiae displays an increased growth rate and an extended replicative lifespan when grown under respiratory conditions in the presence of bacteria

2017 ◽  
Vol 63 (9) ◽  
pp. 806-810
Author(s):  
Paul A. Kirchman ◽  
Nicholas Van Zee
Keyword(s):  
Escherichia Coli ◽  
Saccharomyces Cerevisiae ◽  
Growth Rate ◽  
Volatile Compound ◽  
Lifespan Extension ◽  
Yeast Saccharomyces Cerevisiae ◽  
Replicative Lifespan ◽  
Solid Media ◽  
Respiratory Conditions ◽  
Ferment Glucose

Individual cells of the budding yeast Saccharomyces cerevisiae have a limited replicative potential, referred to as the replicative lifespan. We have found that both the growth rate and average replicative lifespan of S. cerevisiae cells are greatly increased in the presence of a variety of bacteria. The growth and lifespan effects are not observable when yeast are allowed to ferment glucose but are only notable on solid media when yeast are forced to respire due to the lack of a fermentable carbon source. Growth near strains of Escherichia coli containing deletions of genes needed for the production of compounds used for quorum sensing or for the production of the siderophore enterobactin also still induced the lifespan extension in yeast. Furthermore, the bacterially induced increases in growth rate and lifespan occur even across gaps in the growth medium, indicating that the bacteria are influencing the yeast through the action of a volatile compound.

scholarly journals Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yanjun Pan ◽  
Yanan Liu ◽  
Rui Fujii ◽  
Umer Farooq ◽  
Lihong Cheng ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lifespan Extension ◽  
Oxygen Species ◽  
Replicative Lifespan ◽  
Significant Evidence ◽  
Chronological Lifespan ◽  
Healthcare Product ◽  
Autophagy Induction ◽  
Type Molecule ◽  
Antioxidative Stress

The antiaging benzoquinone-type molecule ehretiquinone was isolated in a previous study as a leading compound from the herbal medicine Onosma bracteatum wall. This paper reports the antiaging effect and mechanism of ehretiquinone by using yeasts, mammal cells, and mice. Ehretiquinone extends not only the replicative lifespan but also the chronological lifespan of yeast and the yeast-like chronological lifespan of mammal cells. Moreover, ehretiquinone increases glutathione peroxidase, catalase, and superoxide dismutase activity and reduces reactive oxygen species and malondialdehyde (MDA) levels, contributing to the lifespan extension of the yeasts. Furthermore, ehretiquinone does not extend the replicative lifespan of Δsod1, Δsod2, Δuth1, Δskn7, Δgpx, Δcat, Δatg2, and Δatg32 mutants of yeast. Crucially, ehretiquinone induces autophagy in yeasts and mice, thereby providing significant evidence on the antiaging effects of the molecule in the mammalian level. Concomitantly, the silent information regulator 2 gene, which is known for its contributions in prolonging replicative lifespan, was confirmed to be involved in the chronological lifespan of yeasts and participates in the antiaging activity of ehretiquinone. These findings suggest that ehretiquinone shows an antiaging effect through antioxidative stress, autophagy, and histone deacetylase Sir2 regulation. Therefore, ehretiquinone is a promising molecule that could be developed as an antiaging drug or healthcare product.

scholarly journals Resveratrol shortens the chronological lifespan of Saccharomyces cerevisiae by a pro‐oxidant mechanism

Yeast ◽  
2021 ◽  
Author(s):  
Juan Carlos Canedo‐Santos ◽  
Andres Carrillo‐Garmendia ◽  
Iridian Mora‐Martinez ◽  
Ingrid Karina Gutierrez‐Garcia ◽  
Maria Guadalupe Ramirez‐Romero ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chronological Lifespan

scholarly journals Hydrogen sulfide treatment at the late growth stage of Saccharomyces cerevisiae extends chronological lifespan

Aging ◽  
2021 ◽  
Author(s):  
Arman Ali Shah ◽  
Binghua Liu ◽  
Zhihuai Tang ◽  
Wang Wang ◽  
Wenjie Yang ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Hydrogen Sulfide ◽  
Growth Stage ◽  
Chronological Lifespan ◽  
Late Growth
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