This chapter introduces a new network-centric computing model using Distributed Intelligent Managed Element (DIME) network architecture (DNA). A parallel signaling network overlay over a network of self-managed von Neumann computing nodes is utilized to implement dynamic fault, configuration, accounting, performance, and security management of both the nodes and the network based on business priorities, workload variations and latency constraints. Two implementations of the new computing model are described which demonstrate the feasibility of the new computing model. One implementation provides service virtualization at the Linux process level and another provides virtualization of a core in a many-core processor. Both point to an alternative way to assure end-to-end transaction reliability, availability, performance, and security in distributed Cloud computing, reducing current complexity in configuring and managing virtual machines and making the implementation of Federation of Clouds simpler.