scholarly journals Neutrophil gelatinase-associated lipocalin for early diagnosis of acute kidney injury in patients with acute decompensated heart failure

Kardiologiia ◽  
2018 ◽  
Vol 17 (S10) ◽  
pp. 44-50
Author(s):  
M. V. Ledyakhova ◽  
◽  
S. N. Nasonova ◽  
I. V. Zhirov ◽  
E. B. Yarovaya ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Kidney Injury ◽  
Early Diagnosis ◽  
Acute Decompensated Heart Failure ◽  
Kidney Injury ◽  
Decompensated Heart Failure ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury

2020 ◽  
Vol 48 (11) ◽  
pp. 030006052096782
Author(s):  
Jiaolei Liu ◽  
Hongmei Zhang ◽  
Xin Li ◽  
Lin Wang ◽  
Huining Yu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Kidney Injury ◽  
Early Diagnosis ◽  
Diagnostic Performance ◽  
Acute Decompensated Heart Failure ◽  
Characteristic Curve ◽  
Prognostic Significance ◽  
Kidney Injury ◽  
Decompensated Heart Failure ◽  
Diagnostic Value

Objective This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p. Methods We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed. Results Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival. Conclusion Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.

scholarly journals sCysC for early diagnosis of acute kidney injury in patients with acute decompensated heart failure

2018 ◽  
Vol 13 (3) ◽  
pp. 26
Author(s):  
M. V. Lediakhova ◽  
S. N. Nasonova ◽  
I. V. Zhirov ◽  
E. B. Yarovaya ◽  
T. M. Uskach ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Kidney Injury ◽  
Early Diagnosis ◽  
Acute Decompensated Heart Failure ◽  
Kidney Injury ◽  
Decompensated Heart Failure
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