scholarly journals Am I My Cousin's Keeper? A Proposal to Protect Relatives of Genetic Database Subjects

2021 ◽  
Vol 18 (1) ◽  
pp. 1-55
Author(s):  
Robert I. Field ◽  
Anthony W. Orlando ◽  
Arnold J. Rosoff
Keyword(s):  
Genetic Database

304-OR: Polygenic Risk Score Predicts Type 2 Diabetes Susceptibility in a Diverse Consumer Genetic Database

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 304-OR
Author(s):  
MICHAEL L. MULTHAUP ◽  
RYOSUKE KITA ◽  
NICHOLAS ERIKSSON ◽  
STELLA ASLIBEKYAN ◽  
JANIE SHELTON ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Polygenic Risk Score ◽  
Diabetes Susceptibility ◽  
Genetic Database ◽  
Polygenic Risk

scholarly journals Two Approaches for a Genetic Analysis of Pompe Disease: A Literature Review of Patients with Pompe Disease and Analysis Based on Genomic Data from the General Population

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 601
Author(s):  
Kyung-Sun Park
Keyword(s):  
General Population ◽  
Pompe Disease ◽  
Genomic Data ◽  
Japanese Patients ◽  
Population Database ◽  
Genome Database ◽  
Genetic Database ◽  
Pathogenic Variants ◽  
Reference Genome Database ◽  
Real Patients

In this study, two different approaches were applied in the analysis of the GAA gene. One was analyzed based on patients with Pompe disease, and the other was analyzed based on GAA genomic data from unaffected carriers in a general population genetic database. For this, GAA variants in Korean and Japanese patients reported in previous studies and in patients reported in the Pompe disease GAA variant database were analyzed as a model. In addition, GAA variants in the Korean Reference Genome Database (KRGDB), the Japanese Multi Omics Reference Panel (jMorp), and the Genome Aggregation Database (gnomAD) were analyzed. Overall, approximately 50% of the pathogenic or likely pathogenic variants (PLPVs) found in unaffected carriers were also found in real patients with Pompe disease (Koreans, 57.1%; Japanese, 46.2%). In addition, there was a moderate positive correlation (Spearman’s correlation coefficient of 0.45–0.69) between the proportion of certain PLPVs in patients and the minor allele frequency of their variants in a general population database. Based on the analysis of general population databases, the total carrier frequency for Pompe disease in Koreans and Japanese was estimated to be 1.7% and 0.7%, respectively, and the predicted genetic prevalence was 1:13,657 and 1:78,013, respectively.

BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder

2013 ◽  
Vol 74 (10) ◽  
pp. 727-733 ◽  
Author(s):  
Su-Hua Chang ◽  
Lei Gao ◽  
Zhao Li ◽  
Wei-Na Zhang ◽  
Yang Du ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Genetic Database

FlyBase—The Drosophila genetic database

Development ◽  
1994 ◽  
Vol 120 (7) ◽  
pp. 2077-2079 ◽  
Author(s):  
Michael Ashburner ◽  
Rachel Drysdale
Keyword(s):  
Genetic Database

Comparative Study of Identifying Biomarkers for ASD Classification Using a Genetic Database

2021 ◽  
pp. 1037-1045
Author(s):  
Ayesha Uzma Khan ◽  
M. Shalini ◽  
L. Shweta Bai ◽  
B. Sindhu ◽  
B. S. Roopa
Keyword(s):  
Comparative Study ◽  
Genetic Database

scholarly journals Paramyxo- and Coronaviruses in Rwandan Bats

2019 ◽  
Vol 4 (3) ◽  
pp. 99 ◽  
Author(s):  
Wanda Markotter ◽  
Marike Geldenhuys ◽  
Petrus Jansen van Vuren ◽  
Alan Kemp ◽  
Marinda Mortlock ◽  
...  
Keyword(s):  
Morphological Identification ◽  
Related Sequence ◽  
Genetic Database ◽  
Reverse Transcription Pcr ◽  
Fruit Bat ◽  
Pcr Assays ◽  
Study Sites ◽  
Positive Results ◽  
High Diversity ◽  
Horseshoe Bats

A high diversity of corona- and paramyxoviruses have been detected in different bat species at study sites worldwide, including Africa, however no biosurveillance studies from Rwanda have been reported. In this study, samples from bats collected from caves in Ruhengeri, Rwanda, were tested for the presence of corona- and paramyxoviral RNA using reverse transcription PCR assays. Positive results were further characterized by DNA sequencing and phylogenetic analysis. In addition to morphological identification of bat species, we also did molecular confirmation of species identities, contributing to the known genetic database available for African bat species. We detected a novel Betacoronavirus in two Geoffroy’s horseshoe bats (Rhinolophus clivosus) bats. We also detected several different paramyxoviral species from various insectivorous bats. One of these viral species was found to be homologous to the genomes of viruses belonging to the Jeilongvirus genus. Additionally, a Henipavirus-related sequence was detected in an Egyptian rousette fruit bat (Rousettus aegyptiacus). These results expand on the known diversity of corona- and paramyxoviruses and their geographical distribution in Africa.

Partial UK genetic database planned

10.1038/74581 ◽  
2000 ◽  
Vol 6 (4) ◽  
pp. 359-360 ◽  
Author(s):  
David Dickson
Keyword(s):  
Genetic Database

DNA barcoding reveals CITES-listed species among Taiwanese government-seized chelonian specimens

Genome ◽  
2018 ◽  
Vol 61 (8) ◽  
pp. 615-624 ◽  
Author(s):  
Chia-Hao Chang ◽  
Wei-Yu Dai ◽  
Ting-Yu Chen ◽  
An-Hsin Lee ◽  
Hsuan-Yi Hou ◽  
...  
Keyword(s):  
Law Enforcement ◽  
Dna Barcoding ◽  
Species Delimitation ◽  
Accurate Method ◽  
Morphological Identification ◽  
Biological Processes ◽  
Mitochondrial Cytochrome ◽  
Law Enforcement Agencies ◽  
Genetic Database ◽  
Reference Sequences

Compared to traditional morphological identification, DNA barcoding—molecular identification based on sequencing of a segment of mitochondrial cytochrome c oxidase subunit I (COI)—provides a shortcut to authenticating chelonian identifications. Here, we selected 63 government-seized chelonian specimens deposited at Taipei Zoo for DNA barcoding analysis. DNA barcoding and subsequent phylogenetic analysis successfully authenticated 36 chelonian species, including five that are listed in CITES Appendix I. Approximately 90% (57/63) of the specimens were successfully authenticated by our molecular approach, but lack or error of BOLD reference sequences, biological processes such as hybridization, and uncertain species delimitation all reduced the accuracy of DNA barcoding. To increase the accuracy of DNA barcoding, Taipei Zoo will continue to enrich the BOLD database and also establish a genetic database, to include additional genetic markers, by using government-seized chelonian specimens. A fast and accurate method to authenticate seized samples could assist law enforcement agencies to prosecute criminals and restrict illegal exploitation of wild chelonian resources.

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