The Study of Pelvicaliceal System in Adult Human Kidney

2015 ◽  
Vol 3 (2) ◽  
pp. 12-16 ◽  
Author(s):  
P Mishra ◽  
◽  
D Onkar ◽  
DD Ksheersagar ◽  
D Mishra
Keyword(s):  
Human Kidney ◽  
Adult Human

scholarly journals The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron.

1990 ◽  
Vol 111 (3) ◽  
pp. 1245-1254 ◽  
Author(s):  
M Korhonen ◽  
J Ylänne ◽  
L Laitinen ◽  
I Virtanen
Keyword(s):  
Human Kidney ◽  
Membrane Receptors ◽  
Minor Role ◽  
Integrin Subunit ◽  
Fibronectin Receptor ◽  
Receptor Complexes ◽  
Nephron Segments ◽  
Alpha Subunits ◽  
Adult Human ◽  
Distal Tubules

We studied the distribution of the alpha 1-alpha 6 subunits of beta 1 integrins in developing and adult human kidney using a panel of mAbs in indirect immunofluorescence microscopy. Uninduced mesenchyme displayed a diffuse immunoreactivity for only the alpha 1 integrin subunit. At the S-shaped body stage of nephron development, several of the alpha subunits were characteristically expressed in distinct fetal nephron segments, and the pattern was retained also in the adult nephron. Thus, the alpha 1 subunit was characteristically expressed in mesangial and endothelial cells, the alpha 2 in glomerular endothelium and distal tubules, the alpha 3 in podocytes, Bowman's capsule, and distal tubules, and the alpha 6 subunit basally in all tubules, and only transiently in podocytes during development. Unlike the alpha 3 and alpha 6 subunits, the alpha 2 subunit displayed an overall cell surface distribution in distal tubules. It was also distinctly expressed in glomerular endothelia during glomerulogenesis. The beta 4 subunit was expressed only in fetal collecting ducts, and hence the alpha 6 subunit seems to be complexed with the beta 1 rather than beta 4 subunit in human kidney. Of the two fibronectin receptor alpha subunits, alpha 4 and alpha 5, only the latter was expressed, confined to endothelia of developing and adult blood vessels, suggesting that these receptor complexes play a minor role during nephrogenesis. The present results suggest that distinct integrins play a role during differentiation of specific nephron segments. They also indicate that alpha 3 beta 1 and alpha 6 beta 1 integrin complexes may function as basement membrane receptors in podocytes and tubular epithelial cells.

scholarly journals HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney

1994 ◽  
Vol 45 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Michael J. Ryan ◽  
Gretchen Johnson ◽  
Judy Kirk ◽  
Sally M. Fuerstenberg ◽  
Richard A. Zager ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Proximal Tubule ◽  
Cell Line ◽  
Human Kidney ◽  
Normal Adult ◽  
Epithelial Cell Line ◽  
Adult Human ◽  
Proximal Tubule Epithelial Cell

scholarly journals Small proteoglycans of normal adult human kidney: Distinct expression patterns of decorin, biglycan, fibromodulin, and lumican

2000 ◽  
Vol 58 (4) ◽  
pp. 1557-1568 ◽  
Author(s):  
Liliana Schaefer ◽  
Hermann-Josef Gröne ◽  
Igor Raslik ◽  
Horst Robenek ◽  
Jana Ugorcakova ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Human Kidney ◽  
Normal Adult ◽  
Adult Human

Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney: Evidence for the contribution of bcl-2 expression to renal carcinogenesis

1994 ◽  
Vol 25 (8) ◽  
pp. 789-796 ◽  
Author(s):  
Dawn Chandler ◽  
Adel K. El-Naggar ◽  
Shawn Brisbay ◽  
Raymond W. Redline ◽  
Timothy J. McDonnell
Keyword(s):  
Human Kidney ◽  
Renal Carcinogenesis ◽  
Adult Human

Autoradiographic characterization of angiotensin receptor subtypes in fetal and adult human kidney

1992 ◽  
Vol 262 (2) ◽  
pp. F326-F331 ◽  
Author(s):  
H. J. Grone ◽  
M. Simon ◽  
E. Fuchs
Keyword(s):  
Human Kidney ◽  
Renal Tissue ◽  
Receptor Subtypes ◽  
Ang Ii ◽  
Angiotensin Receptor ◽  
Outer Medulla ◽  
Adult Human ◽  
Tissue Equivalent

To better understand the action of angiotensin II (ANG II) and angiotensin receptor antagonists (ARA) in human kidney, ANG II receptors were characterized by in vitro autoradiography in fetal and adult human renal tissue using 125I-[Sar1-Ile8]ANG II (125I-ANG II), a potent ANG II antagonist. Binding was inhibited with the ARAs DuP 753 and PD 123177, respectively. In adult kidneys (n = 5), binding of 125I-ANG II showed the following characteristics: arterial vessels had dissociation constant (Kd) = 387.6 +/- 29.1 (SD) pM and maximal binding (Bmax) = 41.4 +/- 3.6 fmol/mg tissue equivalent (TE); glomeruli had Kd = 885.7 +/- 217.1 pM and Bmax = 35.5 +/- 8.1 fmol/mg TE; and outer medulla had Kd = 142.1 +/- 52.5 pM and Bmax = 7.7 +/- 2.3 fmol/mg TE. PD 123177 effectively displaced 125I-ANG II only in large preglomerular vessels [half-maximal inhibitory concentration (IC50) = 0.22 +/- 0.1 nM, type 2 receptor (AT2)], whereas DuP 753 displaced only the labeled ligand in glomeruli (IC50 = 0.28 +/- 0.11 nM) and outer medulla (IC50 = 0.39 +/- 0.11 nM, AT1). In fetal kidneys (n = 4), a diffuse 125I-ANG II binding was demonstrated in the medulla (Kd = 36.6 +/- 7.1 pM; Bmax = 25 +/- 3.8 fmol/mg TE) and in the cortex (Kd = 19.5 +/- 8 pM; Bmax = 7.2 +/- 2.2 fmol/mg TE). Both cortical (IC50 = 0.039 +/- 0.019 nM) and medullary binding (IC50 = 0.076 +/- 0.039 nM) could only be displaced by PD 123177.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals CD133+ renal stem cells always co-express CD24 in adult human kidney tissue

2014 ◽  
Vol 12 (3) ◽  
pp. 828-829 ◽  
Author(s):  
Paola Romagnani ◽  
Giuseppe Remuzzi
Keyword(s):  
Stem Cells ◽  
Kidney Tissue ◽  
Human Kidney ◽  
Adult Human ◽  
Renal Stem Cells

Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney

1996 ◽  
Vol 85 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Saibaba Mididoddi ◽  
Joan P. McGuirt ◽  
Mary Ann Sens ◽  
John H. Todd ◽  
Donald A. Sens
Keyword(s):  
Human Kidney ◽  
Specific Expression ◽  
Adult Human
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