scholarly journals Using Multivariate Quantile Regression Analysis to Explore Cardiovascular Risk Differences in Subjects with Chronic Kidney Disease by Race and Ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Longjian Liu
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Renal Insufficiency ◽  
Quantile Regression ◽  
Chronic Renal Insufficiency ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Multivariate Quantile

<p><span style="font-family: Calibri;"><strong>Background and Aims:</strong> Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD).The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD than non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. </span></p><p><strong><span style="font-family: Calibri;"> </span></strong></p><p><span style="font-family: Calibri;"><strong>Methods:</strong> A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVDRisk score by race/ethnicity were tested using quantile regression (Qreg) analysis. </span></p><p><span style="font-family: Calibri;"> </span></p><p><span style="font-family: Calibri;"><strong>Results:</strong> The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p&lt;0.001). The means (SD) of CVDRisk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p&lt;0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m<sup>2</sup> had significantly higher (worse) CVDRisk scores across all quantiles (Qs) than NHW. This race differences in CVDRisk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m<sup>2</sup> in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVDRisk for NHB versus NHW. </span></p><p><span style="font-family: Calibri;"> </span></p><p><span style="font-family: Calibri;"><strong>Conclusion: </strong>NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW. </span></p>

scholarly journals Progression of retinopathy and incidence of cardiovascular disease: findings from the Chronic Renal Insufficiency Cohort Study

2020 ◽  
pp. bjophthalmol-2019-315333
Author(s):  
Juan E Grunwald ◽  
Maxwell Pistilli ◽  
Gui-Shuang Ying ◽  
Maureen G Maguire ◽  
Ebenezer Daniel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Kidney Diseases ◽  
Vascular Pathology ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Increased Risk

PurposeChronic kidney disease (CKD) patients often develop cardiovascular disease (CVD) and retinopathy. The purpose of this study was to assess the association between progression of retinopathy and concurrent incidence of CVD events in participants with CKD.DesignWe assessed 1051 out of 1936 participants in the Chronic Renal Insufficiency Cohort Study that were invited to have fundus photographs obtained at two timepoints separated by 3.5 years, on average.MethodsUsing standard protocols, presence and severity of retinopathy (diabetic, hypertensive or other) and vessel diameter calibre were assessed at a retinal image reading centre by trained graders masked to study participants’ information. Participants with a self-reported history of CVD were excluded. Incident CVD events were physician adjudicated using medical records and standardised criteria. Kidney function and proteinuria measurements along with CVD risk factors were obtained at study visits.ResultsWorsening of retinopathy by two or more steps in the EDTRS retinopathy grading scale was observed in 9.8% of participants, and was associated with increased risk of incidence of any CVD in analysis adjusting for other CVD and CKD risk factors (OR 2.56, 95% CI 1.25 to 5.22, p<0.01). After imputation of missing data, these values were OR=1.66 (0.87 to 3.16), p=0.12.ConclusionProgression of retinopathy is associated with higher incidence of CVD events, and retinal-vascular pathology may be indicative of macrovascular disease even after adjustment for kidney diseases and CVD risk factors. Assessment of retinal morphology may provide important information when assessing CVD in patients with CKD.

scholarly journals Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

2015 ◽  
Vol 115 (9) ◽  
pp. 1281-1286 ◽  
Author(s):  
Marie A. Guerraty ◽  
Boyang Chai ◽  
Jesse Y. Hsu ◽  
Akinlolu O. Ojo ◽  
Yanlin Gao ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Aortic Valve ◽  
Renal Insufficiency ◽  
Chronic Renal Insufficiency

scholarly journals Cardiovascular Risk Factors in Pre-dialysis Chronic Kidney Disease patients of Nepal

2020 ◽  
Vol 9 (2) ◽  
pp. 47-53
Author(s):  
Kashyap Dahal ◽  
A. Baral ◽  
K.K. Sah ◽  
J.R. Shrestha ◽  
A. Niraula ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Multiple Logistic Regression Analysis ◽  
Multiple Logistic Regression ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Traditional Risk Factors

Background and Aims: Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality in patients with chronic kidney disease (CKD) due to increased prevalence of traditional and nontraditional CVD risk factors. Our study aimed to evaluate these risk factors in pre-dialysis Nepalese CKD patients. Methods: This was a cross-sectional study conducted in Department of Nephrology, Bir hospital. Total 100 consecutive pre-dialysis CKD patients were enrolled. Ten traditional and six nontraditional CVD risk factors were analyzed and compared between CKD stages. Descriptive statistics was used to illustrate the socio-demographic and clinical characteristics, chi square test for categorical variables and multiple logistic regression analysis was done to determine the risk factors of CVD in CKD patients. p-value<0.05 was considered to be statistically significant. Results: Mean patient age was 52.03}13.64 years with majority (60%) of the patients being male. Comparison of traditional risk factors in different stages depicted similar trend except for old age in Stage 3 CKD (p=0.002). Anemia (p<0.001), hyperphosphatemia (p=0.01), hyperparathyroidism (p<0.01) and cumulative nontraditional risk factors were significantly higher (p=0.01) in stage 5 CKD. The predicted CVD events by Framingham risk score showed high risk in 37% with no significant difference among the stages. Multiple logistic regression analysis showed increased body mass index, low serum albumin and increased serum phosphate as the three significant predictors for left ventricular hypertrophy. Conclusion: Our study shows that the CVD risk factors were prevailing along the various stages of CKD. The occurrence of non-traditional risk factors increased with increasing stage of CKD.

scholarly journals Neighborhood Food Outlet Access and Dietary Intake among Adults with Chronic Kidney Disease: Results from the Chronic Renal Insufficiency Cohort Study

2020 ◽  
Vol 120 (7) ◽  
pp. 1151-1162.e3 ◽  
Author(s):  
Jessica M. Madrigal ◽  
Esteban Cedillo-Couvert ◽  
Ana C. Ricardo ◽  
Lawrence J. Appel ◽  
Cheryl A.M. Anderson ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Renal Insufficiency ◽  
Dietary Intake ◽  
Chronic Renal Insufficiency ◽  
Food Outlet
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