scholarly journals Estimation of Stature from Second and Fourth Digit Lengths in Young Adults

2019 ◽  
Vol 24 (3) ◽  
pp. 209-213
Author(s):  
Şükriye Deniz Mutluay ◽  
Memduha Gülhal Bozkır
Keyword(s):  
Young Adults ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Descriptive Analysis ◽  
Anthropometric Measurements ◽  
Regression Equations ◽  
P Values ◽  
Fourth Digit ◽  
The Right

Objectives: Estimating stature from long extremity bones, such as femur, humerus, is commonly usedduring forensic examinations. The aim of this study is to estimate stature by anthropometric measurements of right and left-hands second (2D) and fourth digit (4D) lengths. Method:The sample group consisted of 140 young adults, 70 male and 70 females (aged 21-19 years), whose 2D and 4D lengths were measured (using digital vernier caliper) of their left and right hands. One measurement was taken directly from landmarks from the proximal metacarpophalangeal crease to the finger tips. The program SPSS (Version 17.0) was used to make a descriptive analysis, Student’s t-test was usedto analyze the difference in height 2D and 4D between males and females. One-way ANOVA was usedto determine the potential interactions between anthropometric measurements within each other and stature. Pearson Correlation coefficient and related P values were also used. Statistical significance was assigned to p values <0.05. Linear and multiple regressions were also developed. Results:The differences between the right-and the left fingers length values were statistically significant for both sexes (p<0.001). In all, the measurements of males were significantly higher than females. The correlation coefficients between stature and the measurements of second and fourth digit were found to be positive and statistically significant. The highest correlation coefficient between stature and digit length for males regarded the right second digit (r=0.505), and for females, the left second digit (r=0.596). Regression equations were checked for accuracy by comparing the estimated stature and actual stature. Conclusion: Both regression models can...

scholarly journals ETHNO-TERRITORIAL FEATURES OF SOME OSTEOMETRIC PARAMETERS OF THE PROXIMAL PHALANGES OF THE HAND IN MALE CHILDREN AND ADOLESCENTS IN TAJIKISTAN AND WESTERN INDIA

2021 ◽  
Vol 28 (4) ◽  
pp. 38-45
Author(s):  
Sergey V. Matyushechkin
Keyword(s):  
Children And Adolescents ◽  
Correlation Coefficient ◽  
Statistical Significance ◽  
Age Distribution ◽  
Maximum Growth ◽  
Western India ◽  
Regression Equations ◽  
The Right ◽  
Nonparametric Correlation ◽  
The Relationship

The aim of the study is to establish ethno-territorial differences in the linear parameters of the proximal phalanges of the fingers in children and adolescents of the male sex of Tajikistan and Western India, regression equations that allow determining the nature of the dependence of the age of the examined and linear sizes of phalanges. On 366 radiographs of the right hand in children and adolescents aged 6-17 years from Tajikistan and India (Mumbai), the length of the proximal phalanges and the width of their diaphysis were measured. To determine the relationship between the age and the length, as well as the width of the diaphysis, Spearman's nonparametric correlation coefficient was used, because the age distribution does not correspond to normal. One-way ANOVA demonstrates the statistical significance of the increase in the length and width of the diaphysis of the proximal phalanges in boys and young men of Tajikistan and India with age, but the growth of these bones is uneven. For both Tajik and Indian boys, the closest correlation with age was found for the length of the second finger phalanx. It was found that in children in the smallest regions compared, the correlation was determined between their age and the length of the phalanx of the fifth finger. The length of the phalanx of the third finger increased most significantly with age in boys of the compared ethnic groups. The smallest height in length was determined for the phalanx of the fifth finger in boys in India and for the phalanx of the first finger in adolescents in Tajikistan. The maximum growth of the diaphysis in width was observed in the phalanx of the second finger, the smallest in the phalanges of the first and fifth fingers. The highest reliability was found with the length of the phalanx of the second finger. For Tajik boys, the parameters of the length of the phalanges of the III and IV fingers also have a correlation coefficient, therefore, they can be used to identify their age.

Scientific Substantiation of the Innovative Model of Catering for Cadet Corps Students

2020 ◽  
pp. 31-35
Author(s):  
Novikova ◽  
SP Romanenko ◽  
MA Lobkis
Keyword(s):  
Correlation Coefficient ◽  
School Environment ◽  
Developmental Disorders ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Regression Analyses ◽  
Healthy Nutrition ◽  
Innovative Model ◽  
Scientific Substantiation ◽  
Student’S T

Introduction: In the Russian Federation, much attention is traditionally paid to military education and training. A special place in its structure is occupied by the system of cadet classes and corps. A distinctive feature of the learning mode in such institutions is a combined effect of standard and specific factors of indoor school environment and intensive physical activity owing to sports, applied military and drill training. No evidence-based methods of establishing nutrient requirements of children in modern conditions of cadet corps have been developed so far, which predetermines the potential of transforming nutrition from a health-saving factor into a health risk factor. Our objective was to provide a scientific substantiation of the model of healthy nutrition for students of cadet-type educational establishments. Methods: The statistical significance of the correlation was evaluated using the Student’s t-test. Correlation and regression analyses were used to assess cause-and-effect relationships. The Pearson correlation coefficient (rxy) was used as an indicator of the strength of the relationship between quantitative indicators x and y, both having a normal distribution. Correlation coefficient (rxy) values were interpreted in accordance with the Chaddock scale. For the purpose of statistical modeling, the method of multiple linear regressions was used. Conclusions: We substantiated the innovative model of organizing healthy nutrition for students of cadet-type schools based on the correlation and regression analyses with determination of statistical significance of the studied characteristics. Its efficiency indicators include an increase in average functional capabilities of students by more than 10 % and a reduction in the probability of developmental disorders by more than 25 %.

scholarly journals Smartphone Application with Virtual Reality Goggles for the Reliable and Valid Measurement of Active Craniocervical Range of Motion

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 71 ◽  
Author(s):  
Ke-Vin Chang ◽  
Wei-Ting Wu ◽  
Mei-Chu Chen ◽  
Yi-Chi Chiu ◽  
Der-Sheng Han ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Range Of Motion ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Random Effect Model ◽  
Altman Plot ◽  
Rater Reliability ◽  
Hybrid Device ◽  
Flexion Extension ◽  
The Right

Objective: This study aimed to determine the intra-rater and inter-rater reliability and validity of a hybrid device, combining virtual reality goggles, a magnetometer and an inclinometer application for smartphones, to measure craniocervical range. Summary of Background Data: Accurate evaluation of craniocervical range of motion is important for early detection of certain diseased conditions and monitoring the progress of interventions. The universal goniometer is widely used for the measurement but it requires experienced practitioners. Whether a combination of virtual reality goggles and smartphone applications can provide the same or better performance compared with the goniometer is still unknown. Methods: Forty-one healthy adults from the department of physical medicine and rehabilitation were recruited for craniocervical range examination (flexion, extension, side-bending to the right or left and rotating to the right or left) by using the hybrid device and universal goniometer. Using the hybrid device, repeated measurements were performed twice by a primary rater and once by a second rater. The primary rater also conducted a measurement using the universal goniometer in the same cohort. The intra-rater and inter-rater reliability (intra-class correlation coefficient (ICC)) were calculated using the two-way random effect model, whereas the validity was examined by the Pearson correlation coefficient and Bland-and-Altman plot. The interval between the first and second sessions of the measurement for intra-rater reliability was set at 30 min. Results: Excellent intra-rater (ICC ≥ 0.925) and inter-rater (ICC ≥ 0.880) reliability was noted for the hybrid device. The minimal detectable changes from intra-observer and inter-observer comparisons ranged between 4.12° and 7.42° in all six directions. The Bland-and-Altman plot revealed small mean differences (≤1.68°) between the hybrid device and universal goniometer. Both instruments had highly correlated measurements of craniocervical motion (r values ≥ 0.918). Conclusion: For healthy participants, excellent intra-rater and inter-rater reliability was noted for the hybrid device, and the measurements were consistent with the universal goniometer measurements. Future studies are needed to examine whether the device can perform similarly for patients with neck disorders.

scholarly journals Mind your gaps: Overlooking assembly gaps confounds statistical testing in genome analysis

2018 ◽  
Author(s):  
Diana Domanska ◽  
Chakravarthi Kanduri ◽  
Boris Simovski ◽  
Geir Kjetil Sandve
Keyword(s):  
Statistical Tests ◽  
Statistical Significance ◽  
Null Model ◽  
Statistical Testing ◽  
Slight Reduction ◽  
Test Statistic ◽  
Experimental Conditions ◽  
P Values ◽  
Localization Analysis ◽  
The Right

AbstractBackgroundThe difficulties associated with sequencing and assembling some regions of the DNA sequence result in gaps in the reference genomes that are typically represented as stretches of Ns. Although the presence of assembly gaps causes a slight reduction in the mapping rate in many experimental settings, that does not invalidate the typical statistical testing comparing read count distributions across experimental conditions. However, we hypothesize that not handling assembly gaps in the null model may confound statistical testing of co-localization of genomic features.ResultsFirst, we performed a series of explorative analyses to understand whether and how the public genomic tracks intersect the assembly gaps track (hg19). The findings rightly confirm that the genomic regions in public genomic tracks intersect very little with assembly gaps and the intersection was observed only at the beginning and end regions of the assembly gaps rather than covering the whole gap sizes. Further, we simulated a set of query and reference genomic tracks in a way that nullified any dependence between them to test our hypothesis that not avoiding assembly gaps in the null model would result in spurious inflation of statistical significance. We then contrasted the distributions of test statistics and p-values of Monte Carlo simulation-based permutation tests that either avoided or not avoided assembly gaps in the null model when testing for significant co-localization between a pair of query and reference tracks. We observed that the statistical tests that did not account for the assembly gaps in the null model resulted in a distribution of the test statistic that is shifted to the right and a distribu tion of p-values that is shifted to the left (leading to inflated significance).ConclusionOur results shows that not accounting for assembly gaps in statistical testing of co-localization analysis may lead to false positives and over-optimistic findings.

scholarly journals Designing Studies and Evaluating Research Results: Type M and Type S Errors for Pearson Correlation Coefficient

2020 ◽  
Author(s):  
Giulia Bertoldo ◽  
Claudio Zandonella Callegher ◽  
Gianmarco Altoè
Keyword(s):  
Correlation Coefficient ◽  
Effect Size ◽  
Statistical Power ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Design Analysis ◽  
Pearson Correlation Coefficient ◽  
Size Estimation ◽  
Present Contribution ◽  
Effect Size Estimation

It is widely appreciated that many studies in psychological science suffer from low statistical power. One of the consequences of analyzing underpowered studies with thresholds of statistical significance, is a high risk of finding exaggerated effect size estimates, in the right or in the wrong direction. These inferential risks can be directly quantified in terms of Type M (magnitude) error and Type S (sign) error, which directly communicate the consequences of design choices on effect size estimation. Given a study design, Type M error is the factor by which a statistically significant effect is on average exaggerated. Type S error is the probability to find a statistically significant result in the opposite direction to the plausible one. Ideally, these errors should be considered during a prospective design analysis in the design phase of a study to determine the appropriate sample size. However, they can also be considered when evaluating studies’ results in a retrospective design analysis. In the present contribution we aim to facilitate the considerations of these errors in the research practice in psychology. For this reason we illustrate how to consider Type M and Type S errors in a design analysis using one of the most common effect size measures in psychology: Pearson correlation coefficient. We provide various examples and make the R functions freely available to enable researchers to perform design analysis for their research projects.

scholarly journals Managing risk in ski resorts: Environmental factors affecting actual and estimated speed on signposted groomed slopes in a cohort of adult recreational alpine skiers

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256349
Author(s):  
Luis Carus ◽  
Isabel Castillo
Keyword(s):  
Wind Speed ◽  
Correlation Coefficient ◽  
Environmental Conditions ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Maximum Speed ◽  
Pearson Correlation Coefficient ◽  
Ski Resorts

Background Certain weather conditions are clearly harmful, increasing the risk of injury of winter sports participants substantially. The objective of this study was to investigate actual speeds of skiers on signposted groomed slopes and to measure their skill to accurately estimate them with regard to environmental conditions such as visibility, sky cover, snow quality, wind and temperature. Methods The data were obtained from a sample of 421 adult recreational skiers taking ski courses. The Pearson correlation coefficient was used to explore the relationship between actual and estimated speed for all participants. Multiple linear regression analysis was used to measure the effect of environmental conditions on both the skiers’ actual speeds and their errors of estimation. Values of 0.05 or less were considered to indicate statistical significance. Results The Pearson correlation coefficient between estimated and actual speed was 0.90 (P < 0.001). Skiers underestimated their actual speed on average by 13.06 km/h or 24.1%. Visibility, quality of snow and wind speed were shown to significantly affect both actual maximum speed and estimated speed. Good visibility, grippy snow and calm wind were associated with both the highest actual maximum speed and the lowest ability to estimate it. Conclusion Certain environmental conditions are associated with the actual speed at which skiers travel and with their ability to estimate it. Visibility, quality of snow and wind speed seem to influence both actual speed and the ability to estimate it while sky cover and temperature do not. A reinforced understanding of skiing speed on signposted groomed slopes is useful to gain insight into crashes and the mechanisms of resulting injuries, to evaluate means of protection and to devise successful prevention policies in ski resorts.

scholarly journals Effect of gender, muscle type and skinfold thickness on myometric parameters in young people

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12367
Author(s):  
Joanna Mencel ◽  
Anna Jaskólska ◽  
Jaroslaw Marusiak ◽  
Katarzyna Kisiel-Sajewicz ◽  
Magdalena Siemiatycka ◽  
...  
Keyword(s):  
Correlation Coefficient ◽  
Skeletal Muscles ◽  
Biceps Brachii ◽  
Subcutaneous Tissue ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Rank Correlation ◽  
Skinfold Thickness ◽  
Muscle Properties ◽  
Males And Females

Background The aim of the study was to compare the mechanical properties of three human skeletal muscles: biceps brachii (BB), rectus femoris (RF), and tibialis anterior (TA) at rest measured by myoton device in males (n = 16, mean age 21.2 ± 0.6 years) and females (n = 16; 21.2 ± 0.9 years) and to investigate the influence of skin and subcutaneous tissue thickness (skinfold thickness, SFT) and gender on myometric parameters of the three skeletal muscles. Methods We measured the following mechanical and viscoelastic muscle properties using MyotonPRO®: frequency (F [Hz]), decrement (D [log]), stiffness (S [N/m]), relaxation time (R [ms]) and creepability (C [De]). The values of SFT for all selected muscles were assessed by caliper. A mixed-design analysis of variance with gender as between subject comparison was used for assessing the differences between gender and muscles in SFT and each of the myometric parameters separately (F, D, S, R and C). Pearson correlation coefficient or Spearman’s rank correlation coefficient between SFT and myometric parameters was conducted for males, females and males and females together. The level of statistical significance was set at α ≤ 0.05 with Bonferroni correction for multiple comparisons. Results The SFT over the RF, TA, and BB muscles in women was statistically significantly larger compared with that of males. In females and males, the SFT over the RF was larger than over the TA and BB, and the SFT over the TA was larger compared with over the BB. The values of F and S recorded for the TA muscle were the highest among the three muscles, while D, C, and R were lowest in TA but highest in the RF muscle in men and women. The values of F and S were smaller in females than in males. Gender comparison of D, C, and R values showed that only D for the RF was significantly lower in females than in males, and C for the RF and TA was significantly larger in females than in males. Some correlation between SFT and myometric parameters were different between males and females. For example, there was a significant, negative correlation between SFT and F for all muscles in females, and a significant, positive correlation between these parameters for BB and TA (not for RF) in males. For pooled data (males and females together), a negative significant correlation between SFT and F was observed for RF and TA (not significant for BB muscle). Discussion It is concluded that the TA compared with the BB and RF has significantly greater F and S but the smallest D and C and the shortest R. Gender and muscle differences in the SFT may affect the measurements of muscle properties using MyotonPRO®. The relationship between SFT and myometric parameters is different in males and females in the RF, TA, and BB muscles. Therefore, the myometric data should be analyzed in males and females separately.

scholarly journals The Prediction of Atherosclerosis Index Based on Photoplethysmograph

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yibing Li ◽  
Fei Xie ◽  
Xiaoye Ren ◽  
Fenyun Cao
Keyword(s):  
Correlation Coefficient ◽  
Pulse Wave ◽  
Pearson Correlation ◽  
Stiffness Index ◽  
Reflection Index ◽  
Study Results ◽  
The Right ◽  
Bp Neural Network Model ◽  
The Relationship ◽  
Coefficient Method

Current atherosclerosis (AS) assessment devices have a disadvantage for users to carry around. In response to this shortcoming, we propose to collect the wrist photoplethysmograph (PPG) signal and create models to predict the indicators of atherosclerosis (cardiovascular age and right brachial and ankle pulse wave velocity (baPWV)). This study uses the maximum correlation coefficient method for feature selection and establishes multiple models to predict cardiovascular age and the right baPWV. The study results show that the prediction of cardiovascular age using the backpropagation (BP) neural network model is the best. Its Pearson correlation coefficient (PCC) is 0.9501 ( P < 0.05 ), and the model finds the best six physiological features as crest time (CT), crest time ratio (CTR), slop K, stiffness index (SI), reflection index (RI), and heart rate (HR). When predicting the right baPWV value on the right side, we propose a hybrid method MLR_BP, which has better experimental results than BP and MLR. The MLR_BP model improves the prediction accuracy, the predicted PCC value is 0.9204 ( P < 0.05 ), and the model only needs two features, HR and cardiovascular age. This study further verified the results of related literature and proved the relationship between AS and related physiological parameters. The proposed method is applied to wearable devices and has an application value for diagnosing AS and preventing cardiovascular diseases.

scholarly journals Μελέτη της έκφρασης των γονιδίων των κυττάρων του ανθρώπινου περιόστεου

2012 ◽  
Author(s):  
Χρήστος Χασανίδης
Keyword(s):  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Pearson Correlation Coefficient ◽  
P Values

ΕΙΣΑΓΩΓΗ: Το περιόστεο είναι ένα εξειδικευμένος συνδετικός ιστός ο οποίος περιβάλλει τα περισσότερα ανθρώπινα οστά. Υποστηρίζει τον οστίτη ιστό και εξασφαλίζει συνεχή παροχή νέων οστεοβλαστών για την αύξηση, επιδιόρθωση και ομοιοστασία του οστού. Η παρουσία στο περιόστεο πολυδύναμων μεσεγχυματικών κυττάρων, οστεοπρογονικών κυττάρων και αυξητικών παραγόντων, το καθιστά ένα πολύ σημαντικό ιστό για την αναγεννητική διαδικασία του οστού. Οι οστικές μορφογενετικές πρωτεΐνες (BMPs), οι οποίες εκτός των άλλων εδρεύουν και στο περιόστεο, διαδραματίζουν κεντρικό ρόλο μεταξύ των αυξητικών παραγόντων στην ανάπτυξη των οστών, τον ανασχηματισμό και την διαδικασία της πώρωσης των καταγμάτων. ΥΛΙΚΟ και ΜΕΘΟΔΟΙ: Στην παρούσα διδακτορική διατριβή αναλύθηκαν οι ανθρώπινες περιοστικές BMPs και συγκεκριμένα η έκφραση των γονιδίων BMP-2, BMP-4, BMP-6 και BMP-7, σε ένα σύνολο 314 δειγμάτων περιοστέου τα οποία λήφθηκαν από ασθενείς της Ορθοπαιδικής Χειρουργικής Κλινικής του Π.Π.Γ.Ν.Λάρισας κατά τη διάρκεια επανορθωτικών χειρουργικών επεμβάσεων και έκτακτων χειρουργικών επεμβάσεων για την αποκατάσταση καταγμάτων. Το σύνολο των δειγμάτων κατηγοριοποιήθηκε σε φυσιολογικά δείγματα (n=107) και καταγματικά (n=207) εκ των οποίων τα 193 προέρχονταν από την εστία του κατάγματος και τα 14 ήταν από απόσταση από την εστία του κατάγματος. Περαιτέρω κατηγοριοποίηση ανέδειξε τις ομάδες παιδιών και ενηλίκων, ενώ μελετήθηκαν και αναλύθηκαν παράγοντες που πιθανά επηρέαζαν την έκφραση των γονιδίων που ελέγχθηκαν, ανάλογα με τα χαρακτηριστικά των ασθενών (ηλικία, φύλο, κάπνισμα, δείκτης μάζας σώματος) και τα χαρακτηριστικά των δειγμάτων (περιοχή προέλευσης-μηχανική φόρτιση, μέγεθος οστού από όπου προήλθε το δείγμα). Απομονώθηκε γενετικό υλικό από τα δείγματα, στο οποίο μέσω των τεχνικών της μοριακής βιολογίας εφαρμόστηκε ποσοτικοποίηση της έκφρασης για τα γονίδια BMP-2, BMP-4, BMP-6 και BMP-7. Για την ανίχνευση των παραγόντων που έχουν στατιστικά σημαντική επίδραση στις μετρήσεις των BMP2, BMP4, BMP6 και BMP7, χρησιμοποιήθηκαν Γενικά Γραμμικά Μοντέλα μετά από μετασχηματισμό λογαρίθμου. Τα παρατηρούμενα επίπεδα σημαντικότητας (p-values) των διαφορών εκτιμήθηκαν με το κριτήριο Bonferroni ή το Newman – Keuls ανάλογα με την ικανοποίηση ή μη των προϋποθέσεων. Το επίπεδο σημαντικότητας σε όλες τις περιπτώσεις ορίστηκε ίσο με 0.05. Συσχετίσεις μεταξύ συνεχών μεταβλητών εκτιμήθηκαν με το συντελεστή Pearson correlation coefficient. Η ανάλυση πραγματοποιήθηκε με το στατιστικό πακέτο STATISTICA v.8.0. ΑΠΟΤΕΛΕΣΜΑΤΑ: Παρατηρήθηκε ένα ιεραρχικό μοντέλο γονιδιακής έκφρασης σε όλες τις συγκρίσεις και αναλύσεις που εκπονήθηκαν (BMP-2 > BMP-6 > BMP-4 > BMP-7). Διαπιστώθηκε γενική καταστολή της έκφρασης των γονιδίων των BMPs στα κατάγματα σε σχέση με τα φυσιολογικά δείγματα σε όλες τις κατηγορίες. Σημειώθηκε αύξηση της έκφρασης μετά την 30η ημέρα του κατάγματος για όλες τις BMPs. Η γονιδιακή έκφραση των δειγμάτων από απόσταση ήταν μεγαλύτερη από αυτή των καταγμάτων εστίας αλλά μικρότερη από αυτή των φυσιολογικών. Η γονιδιακή έκφραση ήταν μικρότερη στους καπνιστές. Οι γυναίκες παρουσίασαν υψηλότερη γονιδιακή έκφραση συγκριτικά με τους άνδρες. Τα παιδιά, ως επί των πλείστον είχαν υψηλότερη έκφραση από τους ενήλικες ενώ οι ασθενείς άνω των 50 ετών έδειξαν υψηλότερα επίπεδα γονιδιακής έκφρασης από του νεότερους ενήλικες (18-49 ετών). Δεν βρέθηκαν διαφορές μεταξύ άνω και κάτω άκρου. Το μέγεθος του οστού επηρέασε την έκφραση στα κατάγματα. Από την άλλη, καμία διαφορά δεν εντοπίστηκε ανάλογα με τον δείκτη μάζας σώματος των ασθενών στα επίπεδα mRNA των BMPs. Οι ακραίες τιμές δεν επηρέασαν τα αποτελέσματα και καμία συσχέτιση δεν προέκυψε ανάλογα με το οστό προέλευσης του δείγματος. ΣΥΜΠΕΡΑΣΜΑΤΑ: Συνοψίζοντας, από τις αναλύσεις της γονιδιακής έκφρασης των ανθρώπινων περιοστικών BMPs αναδείχθηκε ο πρωταγωνιστικός και πρώιμος ρόλος της BMP-2 στην οστεογενετική σειρά, όπως επίσης επιβεβαιώθηκε και η οστεοεπαγωγική δράση της BMP-6 αφού διατήρησε την έκφρασής της στα κατάγματα όπως αυτή που είχε στα φυσιολογικά. Επιπλέον, φάνηκε πως το γεγονός ενός οστικού τραυματισμού επηρεάζει αρνητικά την γονιδιακή έκφραση ενώ παράγοντες όπως το κάπνισμα, το φύλο, η ηλικία και το μέγεθος του οστού είναι ικανοί να επηρεάσουν χαρακτηριστικά τα επίπεδα γονιδιακής έκφρασης των παραγόντων του περιοστέου. Συμπερασματικά, η κατανόηση της συμπεριφοράς του περιοστέου σε μοριακό επίπεδο μέσω της ανάλυσης των παραγόντων που συμβάλλουν στο ρόλο του (BMPs και άλλων αυξητικών παραγόντων) κατά την ομοιοστασία, αναδόμηση και επουλωτική διαδικασία, θα αναδείξουν τη δυναμική του αλλά και των κυττάρων που βρίσκονται σε αυτό, ως νέα πηγή έμπνευσης και πρώτων υλών για τη νέα αναγεννητική ιατρική.

scholarly journals Cone-beam computed tomography evaluation on the changes in condylar long axis according to asymmetric setback in sagittal split ramus osteotomy patients

2016 ◽  
Vol 87 (2) ◽  
pp. 254-259 ◽  
Author(s):  
Sun-Young Lim ◽  
Tingting Jiang ◽  
Min-Hee Oh ◽  
Min-Suk Kook ◽  
Jin-Hyoung Cho ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Correlation Analysis ◽  
Cone Beam Computed Tomography ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Three Dimensional ◽  
Cone Beam ◽  
Sagittal Split Ramus Osteotomy ◽  
Pearson Correlation Analysis ◽  
The Right

ABSTRACT Objective: To determine whether the condylar rotation is affected by asymmetric setback in patients undergoing sagittal split ramus osteotomy. Materials and Methods: Thirty patients who underwent bilateral sagittal split ramus osteotomy setback surgery were divided into the two groups, symmetric setback and asymmetric setback, according to the right/left difference of setback amount (&lt;2.0, ≥2.0 mm). Condylar long axis changes were evaluated using the three-dimensional superimposition of before and immediately after surgery cone-beam computed tomography volume images. Evaluations were performed separately in lesser setback and greater setback side in patients undergoing asymmetric setback, whereas both side condyles were evaluated together in patients undergoing symmetric setback. Condylar axis changes on axial view were correlated with setback amount or right/left setback difference using Pearson correlation analysis. Results: In general, the condylar axis change occurred in a pattern of inward rotation. The condyles in patients undergoing symmetric setback showed 3.4° rotation in average. In case of asymmetric setback, the lesser setback side showed larger value (4.3°) than the greater setback side (2.3°) with a statistical significance. In the correlation analysis, setback amount showed no significant correlation with the condylar axis changes in both groups. However, correlation with right/left setback difference showed a positive correlation in lesser setback side of patients undergoing asymmetric setback. Conclusion: The findings of this study indicate that large amount of setback alone does not contribute to the change in condylar long axis, but asymmetric setback might cause a change in condylar long axis, particularly on the lesser setback side.

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