scholarly journals Changes in Handwriting due to Alzheimer’s Disease a Case Report

2016 ◽  
Vol 21 (2) ◽  
pp. 116-125
Author(s):  
İsmail Birincioğlu ◽  
Mustafa Uzun ◽  
Nevzat Alkan ◽  
Ömer Kurtaş ◽  
Rıza Yılmaz ◽  
...  

Handwriting and signature comparisons are frequently performed in forensic investigations of documents. Mistakes in conclusion might be due to lack of sufficient documentation and information. Many factors can affect handwriting and signature. These factors are divided into two groups: dependent or independent of the individual at the time the handwriting or signature is made. Therefore, the situations leading to differences between individuals and in the individual’s own handwriting and signature should be determined. Currently, average life expectancy and quality have increased due to the developments in health services. Thus, an increasing number of elderly people are engaged in an active daily life and trade. Alzheimer’s Disease (AD) can develop in the elderly; this is a condition that could alter handwriting and signature considerably over time.In forensic document examination, comparing the document in question containing handwriting or signature with the original documents prepared before the document in question was prepared is important. However, if alterations have developed secondary to a disease, the documents prepared before and after the disease affected the individual should be assessed together.Likewise, in the present case, the examiners making comparisons using handwriting and signatures from different periods reached entirely different conclusions.The case is a bill prepared in 1994. The payee of the bill is a male born in 1925 and diagnosed with AD shortly before his death in 1998. The indebted person in the bill is the payee’s spouse. For the assessment of handwriting and signature, the first endorsement consisting of the handwritten name and signature was used. Several expert reports regarding the same document had been commissioned; these reached different views. The document was sent to The Council of Forensic Medicine to assess the identification and the previous reports. After re-evaluation, the handwriting was declared to belong to the payee.In this study, the reason that the experts delivered opposing opinions on the identification of a document handwritten by a person with AD after being referred to court was investigated.Based on the judicial file, the document examiners did not have the opportunity to evaluate all factors affecting the handwriting or signature of the individual, and an adequate number of handwriting and signature examples were not collected for comparison. Consequently, the examiners reached differing opinions. Thus, the above-mentioned factors are necessary to derive a satisfactory and accurate opinion regarding the identification of handwriting or signature.Keywords: Forensic sciences, handwriting, signature, Alzheimer’s Disease.

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 373
Author(s):  
Marisa Silva ◽  
Paula Seijas ◽  
Paz Otero

Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.


2010 ◽  
Vol 30 (11) ◽  
pp. 1883-1889 ◽  
Author(s):  
Allyson R Zazulia ◽  
Tom O Videen ◽  
John C Morris ◽  
William J Powers

Studies in transgenic mice overexpressing amyloid precursor protein (APP) demonstrate impaired autoregulation of cerebral blood flow (CBF) to changes in arterial pressure and suggest that cerebrovascular dysfunction may be critically important in the development of pathological Alzheimer's disease (AD). Given the relevance of such a finding for guiding hypertension treatment in the elderly, we assessed autoregulation in individuals with AD. Twenty persons aged 75±6 years with very mild or mild symptomatic AD (Clinical Dementia Rating 0.5 or 1.0) underwent 15O-positron emission tomography (PET) CBF measurements before and after mean arterial pressure (MAP) was lowered from 107±13 to 92±9 mm Hg with intravenous nicardipine; 11C-PIB-PET imaging and magnetic resonance imaging (MRI) were also obtained. There were no significant differences in mean CBF before and after MAP reduction in the bilateral hemispheres (−0.9±5.2 mL per 100 g per minute, P=0.4, 95% confidence interval (CI)=−3.4 to 1.5), cortical borderzones (−1.9±5.0 mL per 100 g per minute, P=0.10, 95% CI=−4.3 to 0.4), regions of T2W-MRI-defined leukoaraiosis (−0.3±4.4 mL per 100 g per minute, P=0.85, 95% CI=−3.3 to 3.9), or regions of peak 11C-PIB uptake (−2.5±7.7 mL per 100 g per minute, P=0.30, 95% CI=−7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD.


2020 ◽  
Vol 73 (suppl 3) ◽  
Author(s):  
Maurício Barros ◽  
Claudia Zamberlan ◽  
Maria Helena Gehlen ◽  
Paloma Horbach da Rosa ◽  
Silomar Ilha

ABSTRACT Objective: To describe the contribution of an awareness-raising workshop for nursing students on Alzheimer’s disease in the context of the elderly/family. Methods: Strategic action-research developed with 15 university students from the sixth to the eighth semester of Nursing at a university institution in the Rio Grande do Sul. The data collected through semi-structured interviews, before and after an awareness-raising workshop on Alzheimer’s disease in elderly/family, were subjected to thematic content analysis. Results: Six categories were identified that concern (Mis) perception of Alzheimer’s disease in the context of elderly/ family, from the characterization; risk factors; diagnosis; treatment of Alzheimer’s disease; from care to family members/caregivers; and care strategies for the elderly with Alzheimer’s disease. Conclusion: The awareness-raising workshop enabled the students to broaden and deepen the knowledge on the theme of Alzheimer’s disease in the elderly.


2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Yuan-Yuan Chen ◽  
Min-Chang Wang ◽  
Yan-Ni Wang ◽  
He-He Hu ◽  
Qing-Quan Liu ◽  
...  

Abstract Aging and average life expectancy have been increasing at a rapid rate, while there is an exponential risk to suffer from brain-related frailties and neurodegenerative diseases as the population ages. Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide with a projected expectation to blossom into the major challenge in elders and the cases are forecasted to increase about 3-fold in the next 40 years. Considering the etiological factors of AD are too complex to be completely understood, there is almost no effective cure to date, suggesting deeper pathomechanism insights are urgently needed. Metabolites are able to reflect the dynamic processes that are in progress or have happened, and metabolomic may therefore provide a more cost-effective and productive route to disease intervention, especially in the arena for pathomechanism exploration and new biomarker identification. In this review, we primarily focused on how redox signaling was involved in AD-related pathologies and the association between redox signaling and altered metabolic pathways. Moreover, we also expatiated the main redox signaling-associated mechanisms and their cross-talk that may be amenable to mechanism-based therapies. Five natural products with promising efficacy on AD inhibition and the benefit of AD intervention on its complications were highlighted as well. Graphical Abstract


Author(s):  
Theresa König ◽  
Elisabeth Stögmann

SummaryAlzheimer’s disease (AD) is the leading cause of neurodegeneration in the elderly and is clinically characterized by slowly progressing cognitive decline, which most commonly affects episodic memory function. This eventually leads to difficulties in activities of daily living. Biomarker studies show that the underlying pathology of AD begins 20 years before clinical symptoms. This results in the need to define specific targets and preclinical stages in order to address the problems of this disease at an earlier point in time. Genetic studies are indispensable for gaining insight into the etiology of neurodegenerative diseases and can play a major role in the early definition of the individual disease risk. This review provides an overview of the currently known genetic features of AD.


2018 ◽  
Vol 15 (12) ◽  
pp. 1106-1113 ◽  
Author(s):  
Friedrich Leblhuber ◽  
Kostja Steiner ◽  
Burkhard Schuetz ◽  
Dietmar Fuchs ◽  
Johanna M. Gostner

Background: Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer’s disease. Objective: The rebalancing of the microbiome could benefically impact on gut inflammation and immune activation. Methods: In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76.7 ± 9.6 years) with Alzheimer’s disease were investigated. The mean Mini Mental State Examination score was 18.5 ± 7.7. Biomarkers of immune activation – serum neopterin and tryptophan breakdown - as well as gut inflammation markers and microbiota composition in fecal specimens were analyzed in 18 patients before and after probiotic supplementation for 4 weeks. Results: After treatment a decline of fecal zonulin concentrations and an increase in Faecalibacterium prausnitzii compared to baseline were observed. At the same time, serum kynurenine concentrations increased (p <0.05). Delta values (before - after) of neopterin and the kynurenine to tryptophan ratios (Kyn/Trp) correlated significantly (p <0.05). Conclusion: Results show that the supplementation of Alzheimer’s disease patients with a multispecies probiotic influences gut bacteria composition as well as tryptophan metabolism in serum. The correlation between Kyn/Trp and neopterin concentrations points to the activation of macrophages and/or dendritic cells. Further studies are warranted to dissect the potential consequences of Probiotic supplementation in the course of Alzheimer’s disease.


1992 ◽  
Vol 7 (4) ◽  
pp. 383-385 ◽  
Author(s):  
Debra Cason ◽  
Rosemary Wade Wilson ◽  
Paul K. Chafetz ◽  
Donald D. McIntire

AbstractAccompanying the graying of America is the increased incidence of Alzheimer's Disease (AD) and the need to teach prehospital personnel how to manage these patients. The purpose of this project was to develop an instructional strategy to teach prehospital personnel about AD and some basic management techniques. This information includes: causes of acute and gradual onset confusion in the elderly; symptoms and course of AD; mental status exam; methods to facilitate communication; techniques to avoid confrontation; and means to identify personal feelings about the elderly and AD.Teaching methodology includes instructional objectives, videotape presentation of didactic/clinical material, videotape situations demonstrating patient management techniques, role playing exercises, and discussion groups.The videotape presentation portion of the teaching methodology was shown to be effective as a single instructional strategy. One hundred and thirty-four EMS personnel were given a sixteen item exam before and after the videotape presentation. Pre-test to post-test difference was significant at p=.001. The additional instruction components may further impact the knowledge of AD and positive delivery of care to the elderly.


2020 ◽  
Vol 6 (5) ◽  
pp. 1-7
Author(s):  
Chinonye A Maduagwuna ◽  

Study background: Chronic neuroinflammation is a common emerging hallmark of several neurodegenerative diseases. Alzheimer’s Disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions.


2020 ◽  
Vol 20 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Sharifa Hasana ◽  
Md. Farhad Hossain ◽  
Md. Siddiqul Islam ◽  
Tapan Behl ◽  
...  

: Alzheimer’s disease (AD) is the most common form of dementia in the elderly and this complex disorder is associated with environmental as well as genetic components. Early-onset AD (EOAD) and late-onset AD (LOAD, more common) are major identified types of AD. The genetics of EOAD is extensively understood with three genes variants such as APP, PSEN1, and PSEN2 leading to disease. On the other hand, some common alleles including APOE are effectively associated with LOAD identified but the genetics of LOAD is not clear to date. It has been accounted that about 5% to 10% of EOAD patients can be explained through mutations in the three familiar genes of EOAD. The APOE ε4 allele augmented the severity of EOAD risk in carriers, and APOE ε4 allele was considered as a hallmark of EOAD. A great number of EOAD patients, who are not genetically explained, indicate that it is not possible to identify disease- triggering genes yet. Although several genes have been identified through using the technology of next-generation sequencing in EOAD families including SORL1, TYROBP, and NOTCH3. A number of TYROBP variants were identified through exome sequencing in EOAD patients and these TYROBP variants may increase the pathogenesis of EOAD. The existence of ε4 allele is responsible for increasing the severity of EOAD. However, several ε4 allele carriers live into their 90s that propose the presence of other LOAD genetic as well as environmental risk factors that are not identified yet. It is urgent to find out missing genetics of EOAD and LOAD etiology to discover new potential genetics facets which will assist to understand the pathological mechanism of AD. These investigations should contribute to developing a new therapeutic candidate for alleviating, reversing and preventing AD. This article based on current knowledge represents the overview of the susceptible genes of EOAD, and LOAD. Next, we represent the probable molecular mechanism which might elucidate the genetic etiology of AD and highlight the role of massively parallel sequencing technologies for novel gene discoveries.


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