Evaluation of the Optic Nerve and Retinal Nerve Fibre Layer in Myopic Individuals

2012 ◽  
Vol 06 (05) ◽  
pp. 280
Author(s):  
Ahmad A Aref ◽  
Donald L Budenz ◽  
◽  
Keyword(s):  
Nerve Fibre ◽  
False Positive Rate ◽  
Field Testing ◽  
Retinal Nerve Fibre Layer ◽  
Histopathological Study ◽  
Glaucomatous Optic Neuropathy ◽  
Neuroretinal Rim ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Clinical discrimination between myopic tilted optic discs and glaucomatous optic neuropathy is often challenging, especially when considering that myopia is a risk factor for the development of glaucoma. Myopic tilted discs are usually larger than average, with associated relative cupping and thinner neuroretinal rim tissue. Histopathological study has revealed thinner parapapillary retinal tissue in these eyes. Optical coherence tomography (OCT)-measured average retinal nerve fibre layer (RNFL) thickness has been found to decrease with longer axial length and higher myopic refractive error. Parapapillary RNFL quadrant and clock-hour analyses result in a higher false-positive rate in myopic eyes. Careful slit-lamp examination, quality baseline stereoscopic disc photographs and frequent serial visual field testing are essential to the follow-up of myopic individuals with suspected glaucoma. A novel diagnostic parameter, OCT-derived ganglion cell analysis, may prove to be useful in the diagnosis and follow-up of these individuals.

scholarly journals Diagnostic criteria for detection of retinal nerve fibre layer thickness and neuroretinal rim width abnormalities in glaucoma

2019 ◽  
Vol 104 (2) ◽  
pp. 270-275 ◽  
Author(s):  
Feihui Zheng ◽  
Marco Yu ◽  
Christopher Kai-Shun Leung
Keyword(s):  
Layer Thickness ◽  
Diagnostic Criteria ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Neuroretinal Rim ◽  
Fibre Layer ◽  
Glaucoma Detection ◽  
Nerve Fibre Layer ◽  
Spectralis Oct ◽  
Higher Sensitivity

Background/aimsAlthough measurements of the Bruch’s membrane opening minimum rim width (BMO-MRW) and retinal nerve fibre layer thickness (RNFLT) with optical coherence tomography (OCT) have been widely adopted in the diagnostic evaluation of glaucoma, there is no consensus on the diagnostic criteria to define BMO-MRW and RNFLT abnormalities. This study investigated the sensitivities and specificities of different diagnostic criteria based on the OCT classification reports for detection of glaucoma.Methods340 eyes of 137 patients with glaucoma and 87 healthy individuals, all with axial length ≤26mm, had global and sectoral BMO-MRW and RNFLT measured with Spectralis OCT (Heidelberg Engineering). Six diagnostic criteria were examined: global measurement below the fifth or the first percentile; ≥1 sector measurement below the fifth or the first percentile; superotemporal and/or inferotemporal measurement below the fifth or the first percentile. The sensitivities and specificities of BMO-MRW/RNFLT assessment for detection of glaucoma (eyes with visual field (VF) defects) were compared.ResultsAmong the six criteria examined, superotemporal and/or inferotemporal measurement below the fifth percentile showed the highest sensitivities and specificities for glaucoma detection. Abnormal superotemporal and/or inferotemporal RNFLT attained a higher sensitivity than abnormal superotemporal and/or inferotemporal BMO-MRW to detect mild glaucoma (mean VF MD: −3.32±1.59 dB) (97.9% and 88.4%, respectively, p=0.006), and glaucoma (mean VF MD: −9.36±8.31 dB) (98.4% and 93.6%, respectively, p=0.006), at the same specificity (96.1%).ConclusionsSuperotemporal and/or inferotemporal RNFLT/MRW below the fifth percentile yield the best diagnostic performance for glaucoma detection with RNFLT attains higher sensitivities than MRW at the same specificity in eyes without high myopia.

scholarly journals Factors Associated with Changes in Peripapillary Retinal Nerve Fibre Layer Thickness in Healthy Myopic Eyes

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Jianli Du ◽  
Yang Du ◽  
Yanyan Xue ◽  
He Wang ◽  
Yaping Li
Keyword(s):  
Nerve Fibre ◽  
Open Angle Glaucoma ◽  
False Positive Rate ◽  
Clinical Signs ◽  
Retinal Nerve Fibre Layer ◽  
Retinal Blood Flow ◽  
Glaucoma Diagnosis ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Myopic people face an elevated risk of primary open angle glaucoma. Changes in the fundus in people with high myopia often lead to misdiagnosis of glaucoma, as this condition has many clinical signs in common with myopia, making the diagnosis of glaucoma more challenging. Compared to reduction of the visual field, a decrease in retinal nerve fibre layer (RNFL) thickness occurs earlier in glaucoma, which is widely considered useful for distinguishing between these conditions. With the development of optical coherence tomography (OCT), RNFL thickness can be measured with good reproducibility. According to previous studies, this variable is not only affected by axial length but also related to the patient’s age, gender, ethnicity, optic disc area, and retinal blood flow in myopia. Herein, we intend to summarize the factors relevant to the RNFL in myopia to reduce the false-positive rate of glaucoma diagnosis and facilitate early prevention of myopia.

scholarly journals Application of the ISNT rules on retinal nerve fibre layer thickness and neuroretinal rim area in healthy myopic eyes

2017 ◽  
Vol 96 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Kunliang Qiu ◽  
Geng Wang ◽  
Xuehui Lu ◽  
Riping Zhang ◽  
Lixia Sun ◽  
...  
Keyword(s):  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Neuroretinal Rim ◽  
Fibre Layer ◽  
Neuroretinal Rim Area ◽  
Nerve Fibre Layer

scholarly journals Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis associated with multiple sclerosis in a 6‐month follow‐up

2020 ◽  
Vol 98 (8) ◽  
pp. 841-847
Author(s):  
Tereza Svrčinová ◽  
Pavel Hok ◽  
Irena Šínová ◽  
Tomáš Dorňák ◽  
Michal Král ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Oxygen Saturation ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Evaluation of the Optic Nerve and Retinal Nerve Fiber Layer in Myopic Individuals

2012 ◽  
Vol 05 (02) ◽  
pp. 91
Author(s):  
Ahmad A Aref ◽  
Donald L Budenz ◽  
◽  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
False Positive Rate ◽  
Field Testing ◽  
Glaucomatous Optic Neuropathy ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Neuroretinal Rim ◽  
Retinal Nerve Fiber

Clinical discrimination between myopic tilted optic discs and glaucomatous optic neuropathy is often challenging, especially when considering that myopia is a risk factor for the development of glaucoma. Myopic tilted discs are usually larger than average, with associated relative cupping and thinner neuroretinal rim tissue. Histopathologic study has revealed thinner parapapillary retinal tissue in these eyes. Optical coherence tomography (OCT)-measured average retinal nerve fiber layer (RNFL) thickness has been found to decrease with longer axial length and higher myopic refractive error. Parapapillary RNFL quadrant and clock-hour analyses result in a higher false-positive rate in myopic eyes. Careful slit-lamp examination, quality baseline stereoscopic disc photographs, and frequent serial visual field testing are essential to the follow-up of myopic individuals with suspected glaucoma. A novel diagnostic parameter, OCT-derived ganglion cell analysis, may prove to be useful in the diagnosis and follow-up of these individuals.

scholarly journals Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Metin Ekinci ◽  
Erdinç Ceylan ◽  
Halil Hüseyin Çağatay ◽  
Sadullah Keleş ◽  
Nergiz Hüseyinoğlu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Migraine With Aura ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer
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