Design and Characterization of an Intraoperatively Loaded Protein Delivery Device for the Treatment of Open Tibial Fractures

2021 ◽  
Author(s):  
Aaron Yu
Keyword(s):  
Protein Delivery ◽  
Tibial Fractures ◽  
Delivery Device ◽  
Open Tibial Fractures

scholarly journals Effect of Process Parameters on the Initial Burst Release of Protein-Loaded Alginate Nanospheres

2019 ◽  
Vol 10 (3) ◽  
pp. 42 ◽  
Author(s):  
Farhana Yasmin ◽  
Xiongbiao Chen ◽  
Brian Eames
Keyword(s):  
Process Parameters ◽  
Protein Delivery ◽  
Burst Release ◽  
Delivery Device ◽  
Drying Time ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Alginate Concentration ◽  
Model Protein

The controlled release or delivery of proteins encapsulated in micro/nanospheres is an emerging strategy in regenerative medicine. For this, micro/nanospheres made from alginate have drawn considerable attention for the use as a protein delivery device because of their mild fabrication process, inert nature, non-toxicity and biocompatibility. Though promising, one key issue associated with using alginate micro/nanospheres is the burst release of encapsulated protein at the beginning of the release, which may be responsible for exerting toxic side effects and poor efficiency of the delivery device. To address this issue, this study aimed to investigate the effect of process parameters of fabricating protein-loaded alginate nanospheres on the initial burst release. The alginate nanospheres were prepared via a combination of water-in-oil emulsification and the external gelation method and loaded with bovine serum albumin (BSA) as a model protein. The examined process parameters included alginate concentration, ionic cross-linking time and drying time. Once fabricated, the nanospheres were then subjected to the examination of BSA release, as well as the characterization of their morphology, size, and encapsulation efficiency. Our results revealed that by properly adjusting the process parameters, the initial burst release can be reduced by 13%. Taken together, our study demonstrates that regulating process parameters of fabricating alginate nanospheres is a possible means to reduce the initial burst release.

Effects of hyperbaric oxygen therapy on open tibial fractures in rabbits after transient seawater immersion

2017 ◽  
Vol 44 (3) ◽  
pp. 235-242
Author(s):  
Xiaosong Chen ◽  
◽  
Xunsheng Cheng ◽  
Wuxiu ma ◽  
Congcong Chen ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Tibial Fractures ◽  
Open Tibial Fractures

Treatment of Grade Iiib and Grade Iiic Open Tibial Fractures

1994 ◽  
Vol 25 (4) ◽  
pp. 561-571 ◽  
Author(s):  
Clifford H. Turen ◽  
Anthony J. DiStasio
Keyword(s):  
Tibial Fractures ◽  
Open Tibial Fractures

scholarly journals Experience of treatment for open tibial fractures.

1988 ◽  
Vol 36 (3) ◽  
pp. 932-935
Author(s):  
Satoru Motokawa ◽  
Hideaki Kira ◽  
Tetsuya Niimura ◽  
Seiichiro Watanabe ◽  
Yoshihiro Inoue
Keyword(s):  
Tibial Fractures ◽  
Open Tibial Fractures

scholarly journals Soft tissue management of children's open tibial fractures – a review of seventy children over twenty years

2010 ◽  
Vol 92 (4) ◽  
pp. 320-325 ◽  
Author(s):  
P Rao ◽  
MV Schaverien ◽  
KJ Stewart
Keyword(s):  
Soft Tissue ◽  
Tibial Fractures ◽  
Soft Tissue Management ◽  
Retrospective Case ◽  
Open Tibial Fractures ◽  
Fractures In Children ◽  
Superficial Wound ◽  
Patient Stay ◽  
Grade Ii ◽  
Distally Based

INTRODUCTION The management of open tibial fractures in children represents a unique reconstructive challenge. The aim of the study was to evaluate the management of paediatric open tibial fractures with particular regard to soft tissue management. PATIENTS AND METHODS A retrospective case-note analysis was performed for all children presenting with an open tibial fracture at a single institution over a 20-year period for 1985 to 2005. RESULTS Seventy children were reviewed of whom 41 were males and 29 females. Overall, 91% (n = 64) of children suffered their injury as a result of a vehicle-related injury. The severity of the fracture with respect to the Gustilo classification was: Grade I, 42% (n = 29); Grade II, 24% (n = 17); Grade III, 34% (n = 24; 7 Grade 3a, 16 Grade 3b, 1 Grade 3c). The majority of children were treated with external fixation and conservative measures, with a mean hospital in-patient stay of 13.3 days. Soft tissue cover was provided by plastic surgeons in 31% of all cases. Four cases of superficial wound infection occurred (6%), one case of osteomyelitis and one case of flap failure. The limb salvage was greater than 98%. CONCLUSIONS In this series, complications were associated with delayed involvement of plastic surgeons. Retrospective analysis has shown a decreased incidence of open tibial fractures which is reported in similar studies. Gustilo grade was found to correlate with length of hospital admission and plastic surgery intervention. We advocate, when feasible, the use of local fas-ciocutaneous flaps (such as distally based fasciocutaneous and adipofascial flaps), which showed a low complication rate in children.

scholarly journals From guidelines to standards of care for open tibial fractures

2015 ◽  
Vol 97 (6) ◽  
pp. 469-475 ◽  
Author(s):  
RW Trickett ◽  
S Rahman ◽  
P Page ◽  
I Pallister
Keyword(s):  
Surgical Procedures ◽  
Lower Limb ◽  
Tibial Fractures ◽  
Standards Of Care ◽  
Open Tibial Fractures ◽  
Open Injury ◽  
Initial Surgery ◽  
Transferred Patients ◽  
Combined Strategy ◽  
The Impact

Introduction The standards for the management of open fractures of the lower limb published by the British Association of Plastic, Reconstructive and Aesthetic surgeons (BAPRAS) and British Orthopaedic Association (BOA) were introduced to improve the treatment received by patients after open injury to the lower limb. These Standards were released after BAPRAS/BOA published Guidelines for the management of open tibial fractures. Methods We wished to determine the impact of these Standards upon the surgical management of open tibial fractures by comparing patients admitted to an orthoplastic centre in the 45 months concluding December 2009 (the Guidelines era) with those admitted during 2011 (the Standards era). Surgical procedures required during the first 30 days and 12 months after injury were determined. Cases were divided into ‘directly admitted patients’ (DAP) and ‘transferred patients’ (TP). Standards-era patients were divided further into those who had surgery exclusively at the orthoplastic centre (orthoplastic patients (OPP)) and those transferred after surgery (TASP). Results The number of TP trebled in frequency in the Standards era, 25% of whom were transferred before surgery. Significantly fewer surgical procedures were required for DAP and OPP groups compared with TP (and TASP) groups in both eras (Mann–Whitney U-test, p=0.05). DAP and OPP groups during the Standards era underwent the fewest procedures, with the vast majority of cases treated with two or fewer procedures in the first 12 months (88% and 80%, respectively, compared with 61% in the Guidelines era). In the Guidelines era, 44% of TP cases and in the Standards era 39% of TP and 29% of TASP groups underwent two or fewer procedures. Approximately two-thirds of open tibial fractures managed in our orthoplastic centre were patients transferred after surgery. The greatest impact of the Standards was evident for those who underwent surgery exclusively in the orthoplastic centre, reflecting a more deliberate combined strategy. Conclusion These findings vindicate the Standards as well as mandating reorganisation and resourcing of orthoplastic services to ensure immediate transfer and early combined surgery. By increasing the capacity to deal with time-dependent initial surgery, the surgical burden that the patient must endure, and which the service must provide, are reduced.

Sign in / Sign up

Export Citation Format

Share Document