Characterization of Sentinel Lymph Nodes Using Molecular Imaging with Dual Targeted Microbubbles in a Swine Model

2021 ◽  
Author(s):  
Kartikeya Purnaik
Keyword(s):  
Molecular Imaging ◽  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Swine Model ◽  
Targeted Microbubbles

Contrast-Enhanced US Detection and Characterization of Sentinel Lymph Nodes in a Melanoma Swine Model

2011 ◽  
Vol 37 (8) ◽  
pp. S36
Author(s):  
B. Goldberg ◽  
D.A. Merton ◽  
J. Liu ◽  
F. Forsberg ◽  
K. Zhang ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Swine Model ◽  
Contrast Enhanced

Characterization of sentinel lymph nodes using dual-targeted microbubbles

2016 ◽  
Author(s):  
Kibo Nam ◽  
Maria Stanczak ◽  
Flemming Forsberg ◽  
Ji-Bin Liu ◽  
John R. Eisenbrey ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Targeted Microbubbles

scholarly journals Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Chengyue Li ◽  
Xiaochun Xu ◽  
Nathan McMahon ◽  
Omar Alhaj Ibrahim ◽  
Husain A. Sattar ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Metastatic Breast ◽  
Control Agent ◽  
Sentinel Lymph Nodes ◽  
Imaging Agent ◽  
Binding Potential ◽  
Cancer Spread ◽  
Kinetics Of

Purpose. Paired-agent molecular imaging methods, which employ coadministration of an untargeted, “control” imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods. The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad. Results. The kinetics of ICG and antibody-based imaging agent in tumor-free rat lymph nodes demonstrated a strong correlation with each other (r = 0.98, p<0.001) with a measured binding potential of −0.102 ± 0.03 at 20 min postagent injection, while the kinetics of ICG and targeted imaging agent shows significant separation in the metastatic lymph nodes. Conclusion. This study indicated a potential for microscopic sensitivity to cancer spread in sentinel lymph nodes using ICG as a control agent for antibody-based molecular imaging assays.

Sentinel Lymph Nodes in a Swine Model with Melanoma: Contrast-enhanced Lymphatic US

Radiology ◽  
2004 ◽  
Vol 230 (3) ◽  
pp. 727-734 ◽  
Author(s):  
Barry B. Goldberg ◽  
Daniel A. Merton ◽  
Ji-Bin Liu ◽  
Mathew Thakur ◽  
George F. Murphy ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Swine Model ◽  
Contrast Enhanced

scholarly journals Molecular characterization of breast tumor cells in sentinel lymph nodes

2013 ◽  
Vol 7 (S2) ◽  
Author(s):  
Clarissa Torresan ◽  
Savana CL Santos ◽  
Silma F Pereira ◽  
Marcia M Oliveira ◽  
Rubens S Lima ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Tumor Cells ◽  
Molecular Characterization ◽  
Breast Tumor ◽  
Sentinel Lymph Nodes ◽  
Breast Tumor Cells

Role of High-Resolution Ultrasound and PET/CT Imaging for Preoperative Characterization of Sentinel Lymph Nodes in Cutaneous Melanoma

2013 ◽  
Vol 39 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Torsten Hinz ◽  
Harald Voth ◽  
Hojjat Ahmadzadehfar ◽  
Tobias Hoeller ◽  
Joerg Wenzel ◽  
...  
Keyword(s):  
High Resolution ◽  
Lymph Nodes ◽  
Cutaneous Melanoma ◽  
Sentinel Lymph Nodes ◽  
Ct Imaging ◽  
Pet Ct

Percutaneous removal of sentinel lymph nodes in a swine model using a breast lesion excision system and contrast-enhanced ultrasound

2011 ◽  
Vol 22 (3) ◽  
pp. 545-550 ◽  
Author(s):  
Ali R. Sever ◽  
Philippa Mills ◽  
Jean-Marc Hyvelin ◽  
Jennifer Weeks ◽  
Hatice Gumus ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Breast Lesion ◽  
Sentinel Lymph Nodes ◽  
Swine Model ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Percutaneous Removal

590 MRI characterization of dissected sentinel lymph nodes of breast cancer patients at 7 T

2010 ◽  
Vol 8 (3) ◽  
pp. 231
Author(s):  
M.A. Korteweg ◽  
J.J.M. Zwanenburg ◽  
V.O. Boer ◽  
P.J. Van Diest ◽  
R. Van Hillegersberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Patients

Detection and genomic characterization of occult melanoma cells in sentinel lymph nodes

2006 ◽  
Vol 16 (Supplement 1) ◽  
pp. S62
Author(s):  
A. Ulmer ◽  
J. Fischer ◽  
S. Schanz ◽  
C. Klein ◽  
G. Fierlbeck
Keyword(s):  
Lymph Nodes ◽  
Melanoma Cells ◽  
Sentinel Lymph Nodes ◽  
Genomic Characterization
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