Immunomodulatory effects of IFN-[alpha] on dendritic cells

2021 ◽  
Author(s):  
Mohit Sehgal
Keyword(s):  
Dendritic Cells ◽  
Immunomodulatory Effects ◽  
Ifn Alpha

Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population

Blood ◽  
2009 ◽  
Vol 113 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Bin Zhang ◽  
Rui Liu ◽  
Dan Shi ◽  
Xingxia Liu ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
Immune Cells ◽  
Cell Contact ◽  
Multilineage Differentiation ◽  
Immunomodulatory Effects ◽  
Cd11b Expression ◽  
Dendritic Cell Population

Abstract Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, exert immunomodulatory effects on immune cells, even dendritic cells (DCs). However, whether they influence the destiny of full mature DCs (maDCs) remains controversial. Here we report that MSCs vigorously promote proliferation of maDCs, significantly reduce their expression of Ia, CD11c, CD80, CD86, and CD40 while increasing CD11b expression. Interestingly, though these phenotypes clearly suggest their skew to immature status, bacterial lipopolysaccharide (LPS) stimulation could not reverse this trend. Moreover, high endocytosic capacity, low immunogenicity, and strong immunoregulatory function of MSC-treated maDCs (MSC-DCs) were also observed. Furthermore we found that MSCs, partly via cell-cell contact, drive maDCs to differentiate into a novel Jagged-2–dependent regulatory DC population and escape their apoptotic fate. These results further support the role of MSCs in preventing rejection in organ transplantation and treatment of autoimmune disease.

Purified apoptotic bodies stimulate plasmacytoid dendritic cells to produce IFN-alpha

Autoimmunity ◽  
2007 ◽  
Vol 40 (4) ◽  
pp. 331-332 ◽  
Author(s):  
P. Heyder ◽  
I. Bekeredjian-Ding ◽  
M. Parcina ◽  
N. Blank ◽  
A. D. Ho ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Apoptotic Bodies ◽  
Ifn Alpha

scholarly journals Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses

mBio ◽  
2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Mario Codemo ◽  
Sandra Muschiol ◽  
Federico Iovino ◽  
Priyanka Nannapaneni ◽  
Laura Plant ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasma Membrane ◽  
Streptococcus Pneumoniae ◽  
Extracellular Vesicles ◽  
Factor H ◽  
Host Cells ◽  
Immunomodulatory Effects ◽  
Content Type ◽  
Associated Proteins ◽  
Tract Infections

ABSTRACTGram-positive bacteria, including the major respiratory pathogenStreptococcus pneumoniae, were recently shown to produce extracellular vesicles (EVs) that likely originate from the plasma membrane and are released into the extracellular environment. EVs may function as cargo for many bacterial proteins, however, their involvement in cellular processes and their interactions with the innate immune system are poorly understood. Here, EVs from pneumococci were characterized and their immunomodulatory effects investigated. Pneumococcal EVs were protruding from the bacterial surface and released into the medium as 25 to 250 nm lipid stained vesicles containing a large number of cytosolic, membrane, and surface-associated proteins. The cytosolic pore-forming toxin pneumolysin was significantly enriched in EVs compared to a total bacterial lysate but was not required for EV formation. Pneumococcal EVs were internalized into A549 lung epithelial cells and human monocyte-derived dendritic cells and induced proinflammatory cytokine responses irrespective of pneumolysin content. EVs from encapsulated pneumococci were recognized by serum proteins, resulting in C3b deposition and formation of C5b-9 membrane attack complexes as well as factor H recruitment, depending on the presence of the choline binding protein PspC. Addition of EVs to human serum decreased opsonophagocytic killing of encapsulated pneumococci. Our data suggest that EVs may act in an immunomodulatory manner by allowing delivery of vesicle-associated proteins and other macromolecules into host cells. In addition, EVs expose targets for complement factors in serum, promoting pneumococcal evasion of humoral host defense.IMPORTANCEStreptococcus pneumoniaeis a major contributor to morbidity and mortality worldwide, being the major cause of milder respiratory tract infections such as otitis and sinusitis and of severe infections such as community-acquired pneumonia, with or without septicemia, and meningitis. More knowledge is needed on how pneumococci interact with the host, deliver virulence factors, and activate immune defenses. Here we show that pneumococci form extracellular vesicles that emanate from the plasma membrane and contain virulence properties, including enrichment of pneumolysin. We found that pneumococcal vesicles can be internalized into epithelial and dendritic cells and bind complement proteins, thereby promoting pneumococcal evasion of complement-mediated opsonophagocytosis. They also induce pneumolysin-independent proinflammatory responses. We suggest that these vesicles can function as a mechanism for delivery of pneumococcal proteins and other immunomodulatory components into host cells and help pneumococci to avoid complement deposition and phagocytosis-mediated killing, thereby possibly contributing to the symptoms found in pneumococcal infections.

IFN-alpha in the Generation of Dendritic Cells for Cancer Immunotherapy

2008 ◽  
pp. 295-317 ◽  
Author(s):  
Stefano Maria Santini ◽  
Caterina Lapenta ◽  
Laura Santodonato ◽  
Giuseppina D'Agostino ◽  
Filippo Belardelli ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cancer Immunotherapy ◽  
Ifn Alpha

scholarly journals Cocoa procyanidins modulate transcriptional pathways linked to inflammation and metabolism in human dendritic cells

2018 ◽  
Vol 9 (5) ◽  
pp. 2883-2890 ◽  
Author(s):  
Helene L. E. Midttun ◽  
Aina Ramsay ◽  
Irene Mueller-Harvey ◽  
Andrew R. Williams
Keyword(s):  
Dendritic Cells ◽  
Immunomodulatory Effects ◽  
Cocoa Beans ◽  
Mechanistic Insight ◽  
Human Dendritic Cells ◽  
Insight Into

A mechanistic insight into the immunomodulatory effects of a purified procyanidin fraction from cocoa beans.

Unique immunomodulatory effects of azelastine on dendritic cells in vitro

2014 ◽  
Vol 387 (11) ◽  
pp. 1091-1099 ◽  
Author(s):  
S. Schumacher ◽  
M. Kietzmann ◽  
H. Stark ◽  
W. Bäumer
Keyword(s):  
Dendritic Cells ◽  
Immunomodulatory Effects

C1q inhibits immune complex induced IFN-alpha production in plasmacytoid dendritic cells—A novel link between C1q deficiency and SLE pathogenesis

2009 ◽  
Vol 46 (14) ◽  
pp. 2857
Author(s):  
Christian Lood ◽  
Birgitta Gullstrand ◽  
Lennart Truedsson ◽  
Anders I. Olin ◽  
Gunnar V. Alm ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Complex ◽  
Plasmacytoid Dendritic Cells ◽  
Ifn Alpha ◽  
Alpha Production ◽  
C1q Deficiency

Comparison of the immunomodulatory effects of L. donovani and L. major excreted–secreted antigens, particulate and soluble extracts and viable parasites on human dendritic cells

Vaccine ◽  
2008 ◽  
Vol 26 (48) ◽  
pp. 6119-6123 ◽  
Author(s):  
Matthieu Revest ◽  
Ludovic Donaghy ◽  
Florian Cabillic ◽  
Claude Guiguen ◽  
Jean-Pierre Gangneux
Keyword(s):  
Dendritic Cells ◽  
Immunomodulatory Effects ◽  
Human Dendritic Cells ◽  
Secreted Antigens
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