Mechanisms of axonal pathology in the context of traumatic brain injury

2021 ◽  
Author(s):  
Raha Maryam Dastgheyb
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Pathology

scholarly journals Diverse changes in microglia morphology and axonal pathology during the course of 1 year after mild traumatic brain injury in pigs

2021 ◽  
Author(s):  
Michael R. Grovola ◽  
Nicholas Paleologos ◽  
Daniel P. Brown ◽  
Nathan Tran ◽  
Kathryn L. Wofford ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Axonal Pathology ◽  
Microglia Morphology

scholarly journals SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury

2015 ◽  
Vol 131 (1) ◽  
pp. 115-135 ◽  
Author(s):  
Victoria E. Johnson ◽  
William Stewart ◽  
Maura T. Weber ◽  
D. Kacy Cullen ◽  
Robert Siman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Pathology

scholarly journals Axonal pathology in traumatic brain injury

2013 ◽  
Vol 246 ◽  
pp. 35-43 ◽  
Author(s):  
Victoria E. Johnson ◽  
William Stewart ◽  
Douglas H. Smith
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Pathology

scholarly journals Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs

2020 ◽  
Author(s):  
Michael R. Grovola ◽  
Nicholas Paleologos ◽  
Daniel P. Brown ◽  
Nathan Tran ◽  
Kathryn L. Wofford ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
Periventricular White Matter ◽  
Post Injury ◽  
Mild Tbi ◽  
Time Points ◽  
Axonal Pathology ◽  
The Brain

AbstractOver 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that occur due to TBI propagate through the brain to produce diffuse axonal injury (DAI) and trigger secondary neuroinflammatory cascades. The cascades may persist from acute to chronic time points after injury, altering the homeostasis of the brain. However, the relationship between the hallmark axonal pathology of diffuse TBI and potential changes in glial cell activation or morphology have not been established in a clinically relevant large animal model at chronic time points. In this study, we assessed tissue from pigs subjected to rapid head rotation in the coronal plane to generate mild TBI. Neuropathological assessments for axonal pathology, microglial morphological changes, and astrocyte reactivity were conducted in specimens out to 1 year post injury. We detected an increase in overall amyloid precursor protein pathology, as well as periventricular white matter and fimbria/fornix pathology after a single mild TBI. We did not detect changes in corpus callosum integrity or astrocyte reactivity. However, detailed microglial skeletal analysis revealed changes in morphology, most notably increases in the number of microglial branches, junctions, and endpoints. These subtle changes were most evident in periventricular white matter and certain hippocampal subfields, and were observed out to 1 year post injury in some cases. These ongoing morphological alterations suggest persistent change in neuroimmune homeostasis. Additional studies are needed to characterize the underlying molecular and neurophysiological alterations, as well as potential contributions to neurological deficits.

scholarly journals White Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury

2018 ◽  
Vol 35 (8) ◽  
pp. 1015-1020 ◽  
Author(s):  
Sohae Chung ◽  
Els Fieremans ◽  
Xiuyuan Wang ◽  
Nuri E. Kucukboyaci ◽  
Charles J. Morton ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
White Matter Tract ◽  
Axonal Pathology

P2-250 Short-term accumulation of beta amyloid in axonal pathology following traumatic brain injury in human

2004 ◽  
Vol 25 ◽  
pp. S303 ◽  
Author(s):  
Kunihiro Uryu ◽  
Xiao-Han Chen ◽  
David I. Graham ◽  
Dan Martinez ◽  
Douglas H. Smith ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Beta Amyloid ◽  
Short Term ◽  
Axonal Pathology

scholarly journals Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice

2013 ◽  
Vol 72 (5) ◽  
pp. 396-403 ◽  
Author(s):  
Rachel E. Bennett ◽  
Thomas J. Esparza ◽  
Hal A. Lewis ◽  
Eddie Kim ◽  
Christine L. Mac Donald ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Β ◽  
Apolipoprotein E4 ◽  
Human Apolipoprotein ◽  
Axonal Pathology

scholarly journals The levels of neurofilament light at admission and development of axonal pathology in mild traumatic brain injury

2021 ◽  
Vol 1 ◽  
pp. 100615
Author(s):  
I. Hossain ◽  
M. Mohammadian ◽  
H.-R. Maanpää ◽  
R. Takala ◽  
O. Tenovuo ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Neurofilament Light ◽  
Axonal Pathology
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