Super-porous PVA hydrogels with controlled release of IGF-1 for cartilage tissue engineering

2021 ◽  
Author(s):  
Claire Elizabeth Martin
Keyword(s):  
Tissue Engineering ◽  
Controlled Release ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

scholarly journals Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

2021 ◽  
Author(s):  
Jomarien García-Couce ◽  
Marioly Vernhes ◽  
Nancy Bada ◽  
Lissette Agüero ◽  
Oscar Valdés ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Tissue Engineering ◽  
Scanning Electron Microscopy ◽  
Controlled Release ◽  
Biomedical Applications ◽  
Release Kinetics ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Scanning Electron

Hydrogels obtained from the combination of different polymers are an interesting strategy for the development of controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using different concentration of the components. The hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and swelling degree; betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay shown that almost all hydrogels are cytocompatibles and an increase the proliferation in both cell types after one week of incubation was observed by Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics and biocompatibility.

scholarly journals Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

2021 ◽  
Author(s):  
Jomarien García-Couce ◽  
Marioly Vernhes ◽  
Nancy Bada ◽  
Lissette Agüero ◽  
Oscar Valdés ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Tissue Engineering ◽  
Scanning Electron Microscopy ◽  
Controlled Release ◽  
Biomedical Applications ◽  
Release Kinetics ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Scanning Electron

Hydrogels obtained from the combination of different polymers are an interesting strategy for the development of controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using different concentration of the components. The hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and swelling degree; betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay shown that almost all hydrogels are cytocompatibles and an increase the proliferation in both cell types after one week of incubation was observed by Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics and biocompatibility.

scholarly journals Controlled-release of IGF-I and TGF-β1 in a photopolymerizing hydrogel for cartilage tissue engineering

2001 ◽  
Vol 19 (6) ◽  
pp. 1098-1104 ◽  
Author(s):  
Jennifer Elisseeff ◽  
Winnette McIntosh ◽  
Karen Fu ◽  
Torsten Blunk ◽  
Robert Langer
Keyword(s):  
Tissue Engineering ◽  
Controlled Release ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Igf I ◽  
Tgf Β1
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