A systematic in-vitro and in-vivo toxicity studies of aqueous quantum dots

2021 ◽  
Author(s):  
Thao Nguyen
Keyword(s):  
Quantum Dots ◽  
In Vivo Toxicity ◽  
Toxicity Studies ◽  
Aqueous Quantum Dots

scholarly journals Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies

2019 ◽  
Vol 70 (6) ◽  
pp. 1903-1907
Author(s):  
Roxana Liana Stan ◽  
Bogdan Sevastre ◽  
Adriana Corina Hangan ◽  
Sanda Bota ◽  
Daniela Hanganu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Artemisia Annua ◽  
Histopathological Examination ◽  
Haematological Toxicity ◽  
Chemical Characterization ◽  
In Vivo Toxicity ◽  
Artemisia Annua L ◽  
Toxicity Studies

The purpose of the study was to demonstrate in vitro antioxidant activity and in vivo toxicity of the Artemisia Annua L. extract. The plant was harvested from Bihor area (Crisul Repede and Negru river valleys), Romania. Preparation of the plant product and of the lyophilizated extract was carried out in accordance with the Romanian Pharmacopeia Xth Edition. Lyophilized extract was evaluated in terms of polyphenol content using HPLC method. Antioxidant activity was highlighted using the DPPH, ABTS and FRAP methods. Hepatic, renal and haematological toxicity studies have been performed on laboratory mice. For this purpose blood and organs were collected. Biochemical and haematological parameters were determined on the blood samples and histopathological examination was performed on organs. In vitro antioxidant effect of Artemisia Annua L extract and its lack of in vivo toxicity were demonstrated. It is desirable to obtain a new phytoproduct harvested from spontaneous flora of Romania with antioxidant / antitumoral properties and which is devoid of toxicity.

In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications

2015 ◽  
Vol 11 (4) ◽  
pp. 901-912 ◽  
Author(s):  
Wei Feng ◽  
Wei Nie ◽  
Yanhua Cheng ◽  
Xiaojun Zhou ◽  
Liang Chen ◽  
...  
Keyword(s):  
Copper Sulfide ◽  
In Vivo Toxicity ◽  
Toxicity Studies

Biologically Synthesized Plant-Derived Nanomedicines and Their In vitro-- In vivo Toxicity Studies in Various Cancer Therapeutics: Regulatory Perspectives

2021 ◽  
pp. 217-260
Author(s):  
Mohamed Sheik Tharik Abdul Azeeze ◽  
Santhosh Shanthi Bhupathi ◽  
Elmutaz Belah Mohammad ◽  
Durairaj Kaliannan ◽  
Balamuralikrishnan Balasubramanian ◽  
...  
Keyword(s):  
Cancer Therapeutics ◽  
In Vivo Toxicity ◽  
Toxicity Studies

In Vivo Toxicity Profile of NN-32 and Nanogold Conjugated GNP-NN-32 from Indian Spectacled Cobra Venom

2020 ◽  
Vol 21 (14) ◽  
pp. 1479-1488
Author(s):  
Saurabh S. Attarde ◽  
Sangeeta V. Pandit
Keyword(s):  
Chronic Toxicity ◽  
Significant Inhibition ◽  
Toxicity Profile ◽  
Naja Naja ◽  
In Vivo Toxicity ◽  
Toxicity Studies ◽  
Serum Biochemical ◽  
Reduced Toxicity

Background: NN-32 toxin, which was obtained from Naja naja venom and showed cytotoxicity on cancer cell lines. As the toxicity of NN-32 is the main hurdle in the process of drug development; hence, we have conjugated NN-32 toxin with gold nanoparticles (GNP-NN-32) in order to decrease the toxicity of NN-32 without reducing its efficacy, GNP-NN-32 alleviated the toxicity of NN-32 in in vitro studies during the course of earlier studies. In continuation, we are evaluating in vivo toxicity profile of NN-32 and GNP-NN-32 in the present study. Objective: To study in vivo toxicity profile of NN-32 and nanogold conjugated GNP-NN-32 from Naja naja venom. Materials and Methods: We have carried out in vivo acute toxicity study to determine LD50 dose of GNP-NN-32, in vivo sub-chronic toxicity for 30 days, haematology, serum biochemical parameters and histopathology study on various mice tissues and in vitro cellular and tissue toxicity studies. Results: The LD50 dose of GNP-NN-32 was found to be 2.58 mg/kg (i.p.) in Swiss male albino mice. In vivo sub-chronic toxicity showed significantly reduced toxicity of GNP-NN-32 as compared to NN-32 alone. Discussion: In vitro cellular toxicity studies on human lymphocyte and mouse peritoneal macrophage showed significant inhibition of cells by NN-32 alone. Conclusion: Conjugated GNP-NN-32 toxin showed less in vivo toxicity as compared to pure NN-32.

The in vitro and in vivo toxicity of graphene quantum dots

Biomaterials ◽  
2014 ◽  
Vol 35 (19) ◽  
pp. 5041-5048 ◽  
Author(s):  
Yu Chong ◽  
Yufei Ma ◽  
He Shen ◽  
Xiaolong Tu ◽  
Xuan Zhou ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
In Vivo Toxicity

Are in vitro tests predictive of QT prolongation in human as in vivo toxicity studies are? The example of WIN33377

1998 ◽  
Vol 95 ◽  
pp. 192-193
Author(s):  
P. Gautier ◽  
A. Roberts ◽  
J.P. Bertrand ◽  
A. Barbier ◽  
J. Popp ◽  
...  
Keyword(s):  
Qt Prolongation ◽  
In Vitro Tests ◽  
In Vivo Toxicity ◽  
Toxicity Studies

scholarly journals In vitro and in vivo toxicity studies of Agrobacterium radiobacter k84 biopolymer (ARB)

2011 ◽  
Vol 32 (Suplp) ◽  
pp. 1915-1920
Author(s):  
Caroline Maria Calliari ◽  
Marciane Magnani ◽  
Alexandre Ykuio Saito ◽  
Pedro Sebastiao Dionizio Filho ◽  
Aparecida Donizette Malvezi ◽  
...  
Keyword(s):  
Agrobacterium Radiobacter ◽  
In Vivo Toxicity ◽  
Toxicity Studies

scholarly journals InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment

Nanoscale ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 307-317 ◽  
Author(s):  
Virgilio Brunetti ◽  
Hicham Chibli ◽  
Roberto Fiammengo ◽  
Antonio Galeone ◽  
Maria Ada Malvindi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Toxicity Assessment ◽  
Core Shell ◽  
In Vivo Toxicity
Sign in / Sign up

Export Citation Format

Share Document