Assessing Variabilities for Bioanalytical Methods

2021 ◽  
Author(s):  
Binal Patel
Keyword(s):  
Bioanalytical Methods

Creatinine Deiminase: Characterization, Using in Enzymatic Creatinine Assay, and Production of the Enzyme

2019 ◽  
Vol 20 (5) ◽  
pp. 465-470 ◽  
Author(s):  
Andriy Zakalskiy ◽  
Nataliya Stasyuk ◽  
Mykhailo Gonchar
Keyword(s):  
Quantitative Determination ◽  
Sport Medicine ◽  
Bioanalytical Methods ◽  
Physiological Status ◽  
Recombinant Strains

The goal of the review is description of the main characteristics of creatinine deiminase (CDI), an important bioanalytical tool for creatinine (Crn) assay. Crn is an essential metabolite for diagnostics of kidney disfunction and some other diseases, a biomarker to control the hemodialysis procedure, as well as an important analyte for sport medicine (estimation of general physiological status of athletes). We have described the important sources for CDI isolation, cloning of the corresponding gene, the construction of microbial recombinant strains, overproducing CDI, and characteristics of the enzyme from different microorganisms. There are reviewing also the new bioanalytical methods for quantitative determination of Crn, including enzymatic ones based on using CDI.

Bioanalytical methods for circulating extracellular matrix-related proteins: new opportunities in cancer diagnosis

2021 ◽  
Author(s):  
Ramón Lorenzo-Gómez ◽  
Rebeca Miranda-Castro ◽  
Noemí de-los-Santos-Álvarez ◽  
María Jesús Lobo-Castañón
Keyword(s):  
Extracellular Matrix ◽  
Cancer Diagnosis ◽  
Bioanalytical Methods ◽  
Related Proteins

In vitro tools for the toxicological evaluation of sediments and dredged materials: intra- and inter-laboratory comparisons of chemical and bioanalytical methods

2017 ◽  
Vol 25 (5) ◽  
pp. 4037-4050 ◽  
Author(s):  
Kathrin Eichbaum ◽  
Markus Brinkmann ◽  
Leonie Nuesser ◽  
Carolin Gembé ◽  
Marina Ohlig ◽  
...  
Keyword(s):  
Bioanalytical Methods ◽  
Toxicological Evaluation ◽  
Dredged Materials

A Review: Method Development Validation and Degradation Studies of some Anticancer Drugs

2021 ◽  
pp. 5443-5448
Author(s):  
Punna Venkateshwarlu ◽  
Mehul M. Patel
Keyword(s):  
Liquid Chromatography ◽  
Anticancer Drugs ◽  
Analytical Method ◽  
Analytical Methods ◽  
Bioanalytical Methods ◽  
Method Development ◽  
Estimation Methods ◽  
Simultaneous Estimation ◽  
Pharmaceutical Dosage Forms ◽  
Stability Indicating

This article reviews the various analytical methods reported so far in the literature for the determination of stability and impurity profile the lenalidomide and palbociclib anti cancer drugs in single or combination with other drugs in bulk, pharmaceutical dosage forms, biological fluids, stability indicating and impurity profiling methods. The analytical methods used for the estimation of lenalidomide and palbociclib anticancer drugs reviewed in this paper includes ultraviolet spectrophotometry,high performance liquid chromatography (HPLC) ,ultra performance liquid chromatography (UPLC) ,liquid chromatography-mass spectrometry (LC-MS) and electrophoresis. This review focus on the effect of all chromatographic parameters so as to provide as fast, reliable and cost effective methodology of testing. Method development is the process of proving that analytical method is acceptable for use to measure the concentration of active pharmaceutical ingredient in a specific compound dosage form which must be validated to provide reliable data for regulatory submissions. This reviewed is mainly on analytical method development and validation, stability indicating methods, simultaneous estimation methods and bioanalytical methods. The review covers the time period from 2007 to 2019 during which analytical methods including all types of spectrophotometric and chromatographic techniques were reported. The Review covers lenalidomide and palbociclib API and formulation analytical and bioanalytical methods.

A comparison study of bioanalytical methods for characterization of anti-idursulfase antibodies

Bioanalysis ◽  
2017 ◽  
Vol 9 (16) ◽  
pp. 1237-1246
Author(s):  
Luying Pan ◽  
Kelly Hilton ◽  
Marie Nadeau ◽  
Thomas McCauley ◽  
Yongchang Qiu
Keyword(s):  
Bioanalytical Methods ◽  
Comparison Study

Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review

2010 ◽  
Vol 683 (1) ◽  
pp. 21-37 ◽  
Author(s):  
S.F. Teunissen ◽  
H. Rosing ◽  
A.H. Schinkel ◽  
J.H.M. Schellens ◽  
J.H. Beijnen
Keyword(s):  
Phase I ◽  
Bioanalytical Methods
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