The role of unawareness on functional status in mild Alzheimer's dementia

2021 ◽  
Author(s):  
Emily C. Roseman
Keyword(s):  
Functional Status ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

scholarly journals White Matter and Neuroprotection in Alzheimer’s Dementia

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 503 ◽  
Author(s):  
Luca Lorenzini ◽  
Mercedes Fernandez ◽  
Vito Antonio Baldassarro ◽  
Andrea Bighinati ◽  
Alessandro Giuliani ◽  
...  
Keyword(s):  
White Matter ◽  
Alzheimer’S Dementia ◽  
Oligodendrocyte Precursor Cells ◽  
Resonance Imaging ◽  
Alzheimer's Dementia ◽  
The Central Nervous System ◽  
Oligodendrocyte Precursor ◽  
Main Component ◽  
Preclinical And Clinical Studies

Myelin is the main component of the white matter of the central nervous system (CNS), allowing the proper electrical function of the neurons by ensheathing and insulating the axons. The extensive use of magnetic resonance imaging has highlighted the white matter alterations in Alzheimer’s dementia (AD) and other neurodegenerative diseases, alterations which are early, extended, and regionally selective. Given that the white matter turnover is considerable in the adulthood, and that myelin repair is currently recognized as being the only true reparative capability of the mature CNS, oligodendrocyte precursor cells (OPCs), the cells that differentiate in oligodendrocyte, responsible for myelin formation and repair, are regarded as a potential target for neuroprotection. In this review, several aspects of the OPC biology are reviewed. The histology and functional role of OPCs in the neurovascular-neuroglial unit as described in preclinical and clinical studies on AD is discussed, such as the OPC vulnerability to hypoxia-ischemia, neuroinflammation, and amyloid deposition. Finally, the position of OPCs in drug discovery strategies for dementia is discussed.

P3-096: Role of copper in Alzheimer's dementia: A controlled study

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P656-P657
Author(s):  
Siddhesh Sanjeev Shere ◽  
Srikala Bharath ◽  
Sarada Subramanian ◽  
Meera Purushottam
Keyword(s):  
Alzheimer’S Dementia ◽  
Controlled Study ◽  
Alzheimer's Dementia

scholarly journals Role of neuroimaging in multidisciplinary approach towards Non-Alzheimer’s dementia

2015 ◽  
Vol 6 (5) ◽  
pp. 531-544 ◽  
Author(s):  
Satya Narayana Patro ◽  
Rafael Glikstein ◽  
Prasad Hanagandi ◽  
Santanu Chakraborty
Keyword(s):  
Multidisciplinary Approach ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

scholarly journals Role of tau in Alzheimer's dementia and other neurodegenerative diseases

2007 ◽  
Vol 5 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Amita Quadros ◽  
Ophelia Inez Weeks ◽  
Ghania Ait-Ghezala
Keyword(s):  
Neurodegenerative Diseases ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

Music Cognition in Frontotemporal Dementia and Non-Alzheimer’s Dementias

2019 ◽  
pp. 88-102
Author(s):  
Rohani Omar
Keyword(s):  
Frontotemporal Dementia ◽  
Social Role ◽  
Music Cognition ◽  
Alzheimer’S Dementia ◽  
Healthy Individuals ◽  
Alzheimer's Dementia ◽  
The Social ◽  
The Brain ◽  
Alzheimer's Dementias

This chapter examines how music knowledge is affected in non-Alzheimer’s dementias, with a focus on frontotemporal dementia syndromes. It discusses the clinical and neurobiological rationale for studying music knowledge in non-Alzheimer’s dementia. It describes some of the ways in which music knowledge has been investigated in these patients, what musical abilities are lost or preserved in non-Alzheimer’s dementia, and how this information helps us improve our knowledge of how the brain processes music. The social role of music in evolution is briefly discussed. The chapter examines how emotions generated by and recognized in music are processed differently in frontotemporal dementia compared to healthy individuals and Alzheimer’s disease patients, including the phenomenon of musicophilia, the abnormally enhanced craving for music. Finally it explains how the differences in emotion processing between dementia diseases highlight the need for some selectivity in designing music-based therapies.

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