Identifying genes that encode APP metabolism modulators on chromosome 9q22

2021 ◽  
Author(s):  
Can Zhang
Keyword(s):  
App Metabolism ◽  
Chromosome 9Q22 ◽  
Metabolism Modulators

P2-240: The diabetes associated protein, SorCS1 regulates APP metabolism

2011 ◽  
Vol 7 ◽  
pp. S388-S389
Author(s):  
Rachel Lane ◽  
Alan Attie ◽  
Michelle Ehrlich ◽  
Sam Gandy
Keyword(s):  
App Metabolism

P1-213 ADAM10, ADAM17 and BACE1 downregulation in HEK293 cells: effects on APP metabolism

2004 ◽  
Vol 25 ◽  
pp. S156-S157
Author(s):  
Dario Finazzi ◽  
Maura Poli ◽  
Luisa Benerini Gatta
Keyword(s):  
Hek293 Cells ◽  
App Metabolism

Destructive Basal Cell Carcinoma in a Patient with Basal Cell Nevus Syndrome and an Interstitial Deletion of Chromosome 9q22

2009 ◽  
Vol 35 (12) ◽  
pp. 2051-2053 ◽  
Author(s):  
Klara Mosterd ◽  
Anja Sommer ◽  
Arienne van Marion ◽  
Martin Lacko ◽  
Jos Herbergs ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Interstitial Deletion ◽  
Basal Cell Nevus Syndrome ◽  
Chromosome 9Q22

scholarly journals P1-090: The effects of Alzheimer's disease associated transferrin variants on APP metabolism

2010 ◽  
Vol 6 ◽  
pp. S200-S200
Author(s):  
Celeste M. Karch ◽  
Amanda Jeng ◽  
Carlos Cruchaga ◽  
John S. Kauwe ◽  
Nicole Renaud ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
App Metabolism

A free radical-generating system regulates APP metabolism/processing

FEBS Letters ◽  
2010 ◽  
Vol 584 (22) ◽  
pp. 4611-4618 ◽  
Author(s):  
María Recuero ◽  
Teresa Muñoz ◽  
Jesús Aldudo ◽  
Marta Subías ◽  
María J. Bullido ◽  
...  
Keyword(s):  
Free Radical ◽  
App Metabolism ◽  
Generating System

Regulation of APP Metabolism by Protein Phosphorylation

1998 ◽  
pp. 133-140
Author(s):  
J. D. Buxbaum ◽  
A. Ikin ◽  
Y. Luo ◽  
J. Naslund ◽  
S. Sabo ◽  
...  
Keyword(s):  
Protein Phosphorylation ◽  
App Metabolism

Linkage of recessive Robinow syndrome to a 4 cM interval on chromosome 9q22

2000 ◽  
Vol 106 (3) ◽  
pp. 351-354
Author(s):  
A.R. Afzal ◽  
A. Rajab ◽  
C. Fenske ◽  
A. Crosby ◽  
N. Lahiri ◽  
...  
Keyword(s):  
Robinow Syndrome ◽  
Chromosome 9Q22

The Absence of Myelin Basic Protein Reduces Non-Amyloidogenic Processing of Amyloid Precursor Protein

2021 ◽  
Vol 18 ◽  
Author(s):  
Chika Seiwa ◽  
Ichiro Sugiyama ◽  
Makoto Sugawa ◽  
Hiroaki Murase ◽  
Chiaki Kudoh ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Protein ◽  
Pathological Feature ◽  
Novel Therapy ◽  
App Processing ◽  
App Metabolism

Background: The accumulation of amyloid β-protein (Aβ) in the brain is a pathological feature of Alzheimer’s disease (AD). Aβ peptides originate from amyloid precursor protein (APP). APP can be proteolytically cleaved through amyloidogenic or non-amyloidogenic pathways. The molecular effects on APP metabolism / processing may be influenced by myelin and the breakdown of myelin basic protein (MBP) in AD patients and mouse models of AD pathology. Methods: We directly tested whether MBP can alter influence APP processing in MBP-/- mice, known as Shiverer (shi/shi) mice, in which no functional MBP is produced due to gene breakage from the middle of MBP exon II. Results: A significant reduction of the cerebral sAPPα level in Shiverer (shi/shi) mice was found, although the levels of both total APP and sAPPβ remain unchanged. The reduction of sAPPα was considered to be due to the changes in the expression levels of a disintegrin and metalloproteinase-9 (ADAM9) catalysis and non-amyloid genic processing of APP in the absence of MBP because it binds to ADAM9. MBP -/- mice exhibited increased Aβ oligomer production. Conclusion: Together, these findings suggest that in the absence of MBP, there is a marked reduction of non-amyloidogenic APP processing to sAPPα, and targeting myelin of oligodendrocytes may be a novel therapy for the prevention and treatment of AD.

Mechanistic Studies of the Effect of Presenilins 1 and 2 on APP Metabolism

1998 ◽  
pp. 49-58
Author(s):  
D. J. Selkoe ◽  
W. Xia ◽  
J. Zhang ◽  
M. B. Podlisny ◽  
C. A. Lemere ◽  
...  
Keyword(s):  
Mechanistic Studies ◽  
App Metabolism
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