Nutritional modulation of the innate immune response to influenza infection

2021 ◽  
Author(s):  
Barry W. Ritz
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Influenza Infection ◽  
Innate Immune ◽  
Nutritional Modulation

scholarly journals Supplementation with Active Hexose Correlated Compound Increases the Innate Immune Response of Young Mice to Primary Influenza Infection

2006 ◽  
Vol 136 (11) ◽  
pp. 2868-2873 ◽  
Author(s):  
Barry W. Ritz ◽  
Shoko Nogusa ◽  
Elizabeth A. Ackerman ◽  
Elizabeth M. Gardner
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Influenza Infection ◽  
Innate Immune ◽  
Young Mice

scholarly journals Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a

2013 ◽  
Vol 94 (5) ◽  
pp. 985-995 ◽  
Author(s):  
Olivier Terrier ◽  
Julien Textoris ◽  
Coralie Carron ◽  
Virginie Marcel ◽  
Jean-Christophe Bourdon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Innate Immune Response ◽  
Influenza A ◽  
Influenza Infection ◽  
Influenza Viruses ◽  
Innate Immune ◽  
Biological Processes ◽  
Human Influenza ◽  
Influenza A Viruses

While post-transcriptional regulation of gene expression by microRNAs (miRNAs) has been shown to be involved in influenza virus replication cycle, only a few studies have further investigated this aspect in a human cellular model infected with human influenza viruses. In this study, we performed miRNA global profiling in human lung epithelial cells (A549) infected by two different subtypes of human influenza A viruses (H1N1 and H3N2). We identified a common miRNA signature in response to infection by the two different strains, highlighting a pool of five miRNAs commonly deregulated, which are known to be involved in the innate immune response or apoptosis. Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a. Based on a previously published gene expression dataset, we extracted inversely correlated miR-146a target genes and determined their first-level interactants. This functional analysis revealed eight distinct biological processes strongly associated with these interactants: Toll-like receptor pathway, innate immune response, cytokine production and apoptosis. To better understand the biological significance of miR-146a upregulation, using a reporter assay and a specific anti-miR-146a inhibitor, we confirmed that infection increased the endogenous miR-146a promoter activity and that inhibition of miR-146a significantly increased viral propagation. Altogether, our results suggest a functional role of miR-146a in the outcome of influenza infection, at the crossroads of several biological processes.

A rapid and transient innate immune response to avian influenza infection in mallards

2018 ◽  
Vol 95 ◽  
pp. 64-72 ◽  
Author(s):  
Anu S. Helin ◽  
Michelle Wille ◽  
Clara Atterby ◽  
Josef D. Järhult ◽  
Jonas Waldenström ◽  
...  
Keyword(s):  
Immune Response ◽  
Avian Influenza ◽  
Innate Immune Response ◽  
Influenza Infection ◽  
Innate Immune

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

IL-17C is a mediator of respiratory epithelial innate immune response

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Pfeifer ◽  
M Voss ◽  
B Wonnenberg ◽  
M Bischoff ◽  
F Langer ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Respiratory Epithelial
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