Investigating acetaldehyde-induced DNA protein crosslinks in esophageal cells

2021 ◽  
Author(s):  
Baicheng Lin
Keyword(s):  
Protein Crosslinks

scholarly journals Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

Cell Reports ◽  
2021 ◽  
Vol 34 (10) ◽  
pp. 108820
Author(s):  
Gurushankar Chandramouly ◽  
Shuren Liao ◽  
Timur Rusanov ◽  
Nikita Borisonnik ◽  
Marissa L. Calbert ◽  
...  
Keyword(s):  
End Joining ◽  
Protein Crosslinks

scholarly journals DNA–protein crosslink proteases in genome stability

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Annamaria Ruggiano ◽  
Kristijan Ramadan
Keyword(s):  
Dna Replication ◽  
Cancer Therapy ◽  
Genome Stability ◽  
Dna Lesions ◽  
Protein Component ◽  
Human Diseases ◽  
Direct Link ◽  
The Past ◽  
Protein Crosslinks ◽  
Bulky Dna Lesions

AbstractProteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases, which digest the protein component of a DPC. Interestingly, DPC proteases also play a role in proteolysis beside DPC repair, such as in degrading excess histones during DNA replication or controlling DNA replication checkpoints. Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy.

scholarly journals Improved functional properties of meat analogs by laccase catalyzed protein and pectin crosslinks

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kiyota Sakai ◽  
Yukihide Sato ◽  
Masamichi Okada ◽  
Shotaro Yamaguchi
Keyword(s):  
Sugar Beet ◽  
Free Amino ◽  
Vegetable Protein ◽  
Amino Nitrogen ◽  
Gastrointestinal Digestion ◽  
Binding Ability ◽  
Textured Vegetable Protein ◽  
Protein Crosslinks ◽  
Produce Plant ◽  
Shape And Size

AbstractThe gap between the current supply and future demand of meat has increased the need to produce plant-based meat analogs. Methylcellulose (MC) is used in most commercial products. Consumers and manufacturers require the development of other novel binding systems, as MC is not chemical-free. We aimed to develop a novel chemical-free binding system for meat analogs. First, we found that laccase (LC) synergistically crosslinks proteins and sugar beet pectin (SBP). To investigate the ability of these SBP-protein crosslinks, textured vegetable protein (TVP) was used. The presence of LC and SBP improved the moldability and binding ability of patties, regardless of the type, shape, and size of TVPs. The hardness of LC-treated patties with SBP reached 32.2 N, which was 1.7- and 7.9-fold higher than that of patties with MC and transglutaminase-treated patties. Additionally, the cooking loss and water/oil-holding capacity of LC-treated patties with SBP improved by up to 8.9–9.4% and 5.8–11.3%, compared with patties with MC. Moreover, after gastrointestinal digestion, free amino nitrogen released from LC-treated patties with SBP was 2.3-fold higher than that released from patties with MC. This is the first study to report protein-SBP crosslinks by LC as chemical-free novel binding systems for meat analogs.

Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells

1989 ◽  
Vol 38 (22) ◽  
pp. 4095-4101 ◽  
Author(s):  
Jan M. Woynarowski ◽  
Helen McNamee ◽  
Leszek Szmigiero ◽  
Terry A. Beerman ◽  
Jerzy Konopa
Keyword(s):  
Leukemia Cells ◽  
L1210 Leukemia ◽  
Protein Crosslinks

Cold atmospheric-pressure plasma induces DNA–protein crosslinks through protein oxidation

2018 ◽  
Vol 52 (7) ◽  
pp. 783-798 ◽  
Author(s):  
Li Guo ◽  
Yiming Zhao ◽  
Dingxin Liu ◽  
Zhichao Liu ◽  
Chen Chen ◽  
...  
Keyword(s):  
Protein Oxidation ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma ◽  
Protein Crosslinks
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