Germline-Encoded T-cell Receptor Sequences are a Determinant of Diabetes Susceptibility and Islet-Antigen Recognition in the LEW.1WR1 Rat Model of Type-1 Diabetes

2022 ◽  
Author(s):  
Ryan Anthony Eberwine
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Rat Model ◽  
Cell Receptor ◽  
Antigen Recognition ◽  
Diabetes Susceptibility ◽  
Islet Antigen

108-OR: Islet-Derived Preproinsulin T Cell Receptor Sequences Are Present throughout the Stages of Type 1 Diabetes Development

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 108-OR
Author(s):  
ERIN E. BASCHAL ◽  
ANGELA M. MITCHELL ◽  
KRISTEN MCDANIEL ◽  
AIMON ALKANANI ◽  
TAYLOR ARMSTRONG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Diabetes Development

scholarly journals T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Iria Gomez-Tourino ◽  
Yogesh Kamra ◽  
Roman Baptista ◽  
Anna Lorenc ◽  
Mark Peakman
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor

scholarly journals Reduction of T Cell Receptor Diversity in NOD Mice Prevents Development of Type 1 Diabetes but Not Sjögren’s Syndrome

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112467 ◽  
Author(s):  
Joanna Kern ◽  
Robert Drutel ◽  
Silvia Leanhart ◽  
Marek Bogacz ◽  
Rafal Pacholczyk
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Sjögren's Syndrome ◽  
Nod Mice ◽  
Cell Receptor ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals T Cell Receptor Profiling in Type 1 Diabetes

2017 ◽  
Vol 17 (11) ◽  
Author(s):  
Laura M. Jacobsen ◽  
Amanda Posgai ◽  
Howard R. Seay ◽  
Michael J. Haller ◽  
Todd M. Brusko
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor

T-cell receptor repertoire analysis in monozygotic twins concordant and discordant for type 1 diabetes

Immunobiology ◽  
2012 ◽  
Vol 217 (9) ◽  
pp. 920-925 ◽  
Author(s):  
Claudio Fozza ◽  
Salvatore Contini ◽  
Giovanna Corda ◽  
Patrizia Virdis ◽  
Antonio Galleu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Monozygotic Twins ◽  
Cell Receptor ◽  
Receptor Repertoire ◽  
Repertoire Analysis ◽  
T Cell Receptor Repertoire ◽  
Cell Receptor Repertoire

scholarly journals The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes

2021 ◽  
Vol 11 ◽  
Author(s):  
Matthew Clark ◽  
Charles J. Kroger ◽  
Qi Ke ◽  
Roland M. Tisch
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Response ◽  
Peripheral Tolerance ◽  
Tcr Signaling ◽  
Signaling Events ◽  
Cell Gene Expression

T cell receptor (TCR) signaling influences multiple aspects of CD4+ and CD8+ T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function.

Modulatory effect of insulin on T cell receptor mediated calcium signaling is blunted in long lasting type 1 diabetes mellitus

2012 ◽  
Vol 64 (1) ◽  
pp. 150-156 ◽  
Author(s):  
Urszula Demkow ◽  
Paweł Winklewski ◽  
Olga Ciepiela ◽  
Katarzyna Popko ◽  
Anna Lipińska ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Type 1 Diabetes Mellitus ◽  
Calcium Signaling ◽  
T Cell Receptor ◽  
Cell Receptor

scholarly journals UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor–Induced NF-κB Signaling

Diabetes ◽  
2017 ◽  
Vol 66 (7) ◽  
pp. 2033-2043 ◽  
Author(s):  
Yan Ge ◽  
Taylor K. Paisie ◽  
Jeremy R.B. Newman ◽  
Lauren M. McIntyre ◽  
Patrick Concannon
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor

scholarly journals CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes

Immunology ◽  
2017 ◽  
Vol 152 (2) ◽  
pp. 243-254 ◽  
Author(s):  
Gisela M. Vaitaitis ◽  
Dan M. Waid ◽  
Martin G. Yussman ◽  
David H. Wagner
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Expression
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