Impact of sleep on incubation of cocaine craving and dopamine terminal adaptations following abstinence

2021 ◽  
Author(s):  
Ilse Pamela Alonso
Keyword(s):  
Cocaine Craving

Daily and Weekly Patterns in Heroin and Cocaine Craving and Use

2008 ◽  
Author(s):  
Kenzie L. Preston ◽  
Jessica Willner-Reid ◽  
Jia-Ling Lin ◽  
Massoud Vahabzadeh ◽  
David H. Epstein
Keyword(s):  
Cocaine Craving

scholarly journals Noradrenergic correlates of chronic cocaine craving: neuromelanin and functional brain imaging

2021 ◽  
Author(s):  
Wuyi Wang ◽  
Simon Zhornitsky ◽  
Sheng Zhang ◽  
Chiang-shan R. Li
Keyword(s):  
Functional Brain Imaging ◽  
Cocaine Exposure ◽  
Imaging Data ◽  
Significant Group ◽  
Motivated Behavior ◽  
Chronic Cocaine ◽  
Cocaine Craving ◽  
Lc Circuit ◽  
Psychophysiological Interaction ◽  
Subcortical Regions

AbstractPreclinical studies have implicated noradrenergic (NA) dysfunction in cocaine addiction. In particular, the NA system plays a central role in motivated behavior and may partake in the regulation of craving and drug use. Yet, human studies of the NA system are scarce, likely hampered by the difficulty in precisely localizing the locus coeruleus (LC). Here, we used neuromelanin imaging to localize the LC and quantified LC neuromelanin signal (NMS) intensity in 44 current cocaine users (CU; 37 men) and 59 nondrug users (NU; 44 men). We also employed fMRI to investigate cue-induced regional responses and LC functional connectivities, as quantified by generalized psychophysiological interaction (gPPI), in CU. Imaging data were processed by published routines and the findings were evaluated with a corrected threshold. We examined how these neural measures were associated with chronic cocaine craving, as assessed by the Cocaine Craving Questionnaire (CCQ). Compared to NU, CU demonstrated higher LC NMS for all probabilistic thresholds defined of 50–90% of the peak. In contrast, NMS of the ventral tegmental area/substantia nigra (VTA/SN) did not show significant group differences. Drug as compared to neutral cues elicited higher activations of many cortical and subcortical regions, none of which were significantly correlated with CCQ score. Drug vs. neutral cues also elicited “deactivation” of bilateral parahippocampal gyri (PHG) and PHG gPPI with a wide array of cortical and subcortical regions, including the ventral striatum and, with small volume correction, the LC. Less deactivation of the PHG (r = 0.40, p = 0.008) and higher PHG-LC gPPI (r = 0.44, p = 0.003) were positively correlated with the CCQ score. In contrast, PHG-VTA/SN connectivity did not correlate with the CCQ score. Together, chronic cocaine exposure may induce higher NMS intensity, suggesting neurotoxic effects on the LC. The correlation of cue-elicited PHG LC connectivity with CCQ score suggests a noradrenergic correlate of chronic cocaine craving. Potentially compensating for memory functions as in neurodegenerative conditions, cue-elicited PHG LC circuit connectivity plays an ill-adaptive role in supporting cocaine craving.

scholarly journals Effects of environmental enrichment on the incubation of cocaine craving

2012 ◽  
Vol 63 (4) ◽  
pp. 635-641 ◽  
Author(s):  
Claudia Chauvet ◽  
Steven R. Goldberg ◽  
Mohamed Jaber ◽  
Marcello Solinas
Keyword(s):  
Environmental Enrichment ◽  
Cocaine Craving

scholarly journals Repeated restraint stress exposure during early withdrawal accelerates incubation of cue-induced cocaine craving

2016 ◽  
Vol 23 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Ryan M. Glynn ◽  
J. Amiel Rosenkranz ◽  
Marina E. Wolf ◽  
Aaron Caccamise ◽  
Freya Shroff ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Stress Exposure ◽  
Early Withdrawal ◽  
Repeated Restraint Stress ◽  
Cocaine Craving

Initial validation of the Voris cocaine craving scale: A preliminary report

1999 ◽  
Vol 55 (1) ◽  
pp. 135-139 ◽  
Author(s):  
David A. Smelson ◽  
Eileen McGee-Caulfield ◽  
Pauline Bergstein ◽  
Charles Engelhart
Keyword(s):  
Preliminary Report ◽  
Initial Validation ◽  
Cocaine Craving

scholarly journals Activation of memory circuits during cue-elicited cocaine craving.

1996 ◽  
Vol 93 (21) ◽  
pp. 12040-12045 ◽  
Author(s):  
S. Grant ◽  
E. D. London ◽  
D. B. Newlin ◽  
V. L. Villemagne ◽  
X. Liu ◽  
...  
Keyword(s):  
Memory Circuits ◽  
Cocaine Craving

Haloperidol antagonism of cue-elicited cocaine craving

The Lancet ◽  
1996 ◽  
Vol 347 (9000) ◽  
pp. 504-508 ◽  
Author(s):  
S.P Berger ◽  
M.S Reid ◽  
K Delucchi ◽  
Sharon Hall ◽  
Stephen Hall ◽  
...  
Keyword(s):  
Cocaine Craving

scholarly journals Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca2+-permeable AMPA receptors during the incubation of cocaine craving

2011 ◽  
Vol 61 (7) ◽  
pp. 1141-1151 ◽  
Author(s):  
Carrie R. Ferrario ◽  
Jessica A. Loweth ◽  
Mike Milovanovic ◽  
Kerstin A. Ford ◽  
Gregorio L. Galiñanes ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Cocaine Craving ◽  
Rat Nucleus Accumbens
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