Dietary wheat bran protects against induced colon carcinogenesis

2021 ◽  
Author(s):  
Dana Charlene Widener Compher
Keyword(s):  
Wheat Bran ◽  
Colon Carcinogenesis

Intervention of Acidophilus-casei dahi and Wheat bran against molecular alteration in colon carcinogenesis

2009 ◽  
Vol 37 (1) ◽  
pp. 621-627 ◽  
Author(s):  
Arvind Kumar ◽  
Nikhlesh Kumar Singh ◽  
Pushpalata Rabindra Sinha ◽  
Raj Kumar
Keyword(s):  
Wheat Bran ◽  
Colon Carcinogenesis ◽  
Molecular Alteration

scholarly journals Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa

2000 ◽  
Vol 84 (5) ◽  
pp. 635-643 ◽  
Author(s):  
Anne-Maria Pajari ◽  
Seija Oikarinen ◽  
Soile Gråsten ◽  
Marja Mutanen
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Wheat Bran ◽  
High Fat Diet ◽  
Colon Carcinogenesis ◽  
Rat Colon ◽  
High Fat ◽  
Tumour Development ◽  
Kinase C ◽  
Cereal Brans

The role of dietary fibres in colon carcinogenesis is controversial. To elucidate the mechanisms by which different dietary fibre sources may affect colonic tumour development, we studied the effects of diets enriched with cereal brans or inulin on protein kinase C (PKC) activity and isozyme expression in rat colon. Male Wistar rats (twelve per group) were fed one of the following AIN-93G-based diets () for 4 weeks: a non-fibre high-fat diet or one of the four high-fat diets supplemented with either rye, oat or wheat bran or inulin at 100 g/kg diet. The fat concentration (20 g/100 g) and fatty acid composition of the non-fibre high-fat diet was designed to approximate that in a typical Western-type diet. In the proximal colon, rats fed the inulin diet had a significantly higher membrane PKC activity and a higher membrane PKC δ level than rats fed the non-fibre diet (P<0·05). In the distal colon, rats fed the inulin and oat bran diets had a higher total PKC activity and a higher membrane PKC β2 level than rats fed the wheat-bran diet. Rats in the non-fibre and wheat-bran groups had the lowest concentrations of luminal diacylglycerol. In conclusion, feeding of wheat bran resulted in low distal PKC activity and expression of PKC β2, a PKC isozyme related to colonic cell proliferation and increased susceptibility for colon carcinogenesis, which may explain in part the protective effect of wheat bran against tumour development in a number of experimental colon cancer studies. The increase in PKC activity and PKC β2 expression by feeding inulin may be a drawback of inulin as a functional food.

Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice

1999 ◽  
Vol 141 (1-2) ◽  
pp. 139-146 ◽  
Author(s):  
Takuya Takahashi ◽  
Mikiko Satou ◽  
Nami Watanabe ◽  
Yukiko Sakaitani ◽  
Akimitsu Takagi ◽  
...  
Keyword(s):  
Wheat Bran ◽  
Colon Carcinogenesis ◽  
Inhibitory Effect
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