A proton-sensitive ribozyme switch with "Molecular Memory"

As CMOS technology extends beyond the current technology node, many challenges to conventional MOSFET were raised. Non-classical CMOS to extend and fundamentally new technologies to replace current CMOS technology are under intensive investigation to meet these challenges. The approach of hybrid silicon/molecular electronics is to provide a smooth transition technology by integrating molecular intrinsic scalability and diverse properties with the vast infrastructure of traditional MOS technology. Here we discuss: (1) the integration of redox-active molecules into Si -based structures, (2) characterization and modeling of the properties of these Si /molecular systems, (3) single and multiple states of Si /molecular memory, and (4) applications based on hybrid Si /molecular electronic system.

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2P501 Molecular addressing enlarge the capacity of DNA molecular memory immobilized on a substrate(51. New methods and tools (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Seibutsu Butsuri ◽

10.2142/biophys.46.s421_1 ◽

2006 ◽

Vol 46 (supplement2) ◽

pp. S421

Author(s):

Takahiko Endoh ◽

Masahiro Takinoue ◽

Akira Suyama

Keyword(s):

Poster Session ◽

Molecular Memory ◽

New Methods ◽

Meeting Program

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Heat acclimation memory: do the kinetics of the deacclimated transcriptome predispose to rapid reacclimation and cytoprotection?

Journal of Applied Physiology ◽

10.1152/japplphysiol.00422.2014 ◽

2014 ◽

Vol 117 (11) ◽

pp. 1262-1277 ◽

Cited By ~ 12

Author(s):

Anna Tetievsky ◽

Miri Assayag ◽

Rotem Ben-Hamo ◽

Sol Efroni ◽

Gal Cohen ◽

...

Keyword(s):

Heat Acclimation ◽

Left Ventricular ◽

Molecular Memory ◽

Transcriptional Responses ◽

Linker Histones ◽

Chromatin Compaction ◽

Physiological Adaptations ◽

C 30 ◽

Kinetics Of ◽

Mrna Hybridization

Faster reinduction of heat acclimation (AC) after its decline indicates “AC memory.” Our previous results revealed involvement of epigenetic mechanisms of transcriptional regulation. We hypothesized that the decline of AC (DeAC) is a period of “dormant memory” during which many processes are alerted to enable rapid reacclimation (ReAC). Using a genomewide approach we studied the AC, DeAC, and ReAC transcriptomes, to uncover hallmark pathways linked to “molecular memory” in the cardioacclimatome. Fifty rats subjected to heat acclimation [34°C for 2d (AC2d) or 30d (AC30)], DeAC (24°C, 30 days), ReAC (34°C, 2 days), and untreated controls were used. The GeneChip Rat Gene 1.0 ST Array was employed for left ventricular (cardiac) mRNA hybridization. Three independent bioinformatic analyses showed that 1) during AC2d enrichment of DNA impair/repair-linked genes is seen, and this is the molecular on-switch of acclimation; 2) genes activated in AC30 underlie the qualitative physiological adaptations of cardiac performance; 3) particular molecular programs encompassing constitutive upregulation of p38 MAPK, Jak/Stat, and Akt pathways and targets are specifically activated during DeAC and ReAC; and 4) epigenetic markers such as linker histones (histones H1 cluster), associated with nucleosome spacing, transcriptional chromatin modifiers, poly-(ADP-ribose) polymerase-1 (PARP1) linked to chromatin compaction, and microRNAs are only altered during DeAC/ReAC. The latter are newcomers to the AC/DeAC puzzle. We suggest that these transcriptional responses maintain euchromatin and proteostasis and enable faster physiological recovery upon ReAC by rapidly reestablishing the protected acclimated cardiophenotype. We propose that the cardiac AC model can be applied to acclimation processes in general.

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Mapping Molecular Memory: Navigating the Cellular Pathways of Learning

Cellular and Molecular Neurobiology ◽

10.1007/s10571-012-9836-0 ◽

2012 ◽

Vol 32 (6) ◽

pp. 919-941 ◽

Cited By ~ 14

Author(s):

Gavin R. Owen ◽

Elisabeth Anne Brenner

Keyword(s):

Molecular Memory ◽

Cellular Pathways

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