The role of the ATP-binding cassette transporter A1 (ABCA1) in cholesterol metabolism

2021 ◽  
Author(s):  
Anna E. Bortnick
Keyword(s):  
Cholesterol Metabolism ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals The Role of Apolipoprotein A-I Helix 10 in Apolipoprotein-mediated Cholesterol Efflux via the ATP-binding Cassette Transporter ABCA1

2002 ◽  
Vol 277 (42) ◽  
pp. 39477-39484 ◽  
Author(s):  
Stacey E. Panagotopulos ◽  
Scott R. Witting ◽  
Erica M. Horace ◽  
David Y. Hui ◽  
J. Nicholas Maiorano ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Apolipoprotein A ◽  
Atp Binding Cassette

scholarly journals Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes

2020 ◽  
Vol 34 ◽  
pp. 16-26
Author(s):  
Jingya Lyu ◽  
Hitomi Imachi ◽  
Kensaku Fukunaga ◽  
Seisuke Sato ◽  
Toshihiro Kobayashi ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Atp Binding Cassette

The role of ATP-binding cassette transporter genes in the progression of prostate cancer

The Prostate ◽  
2015 ◽  
Vol 76 (5) ◽  
pp. 434-444 ◽  
Author(s):  
Omer F. Karatas ◽  
Esra Guzel ◽  
Mehmet B. Duz ◽  
Michael Ittmann ◽  
Mustafa Ozen
Keyword(s):  
Prostate Cancer ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol Efflux†

Biochemistry ◽  
2007 ◽  
Vol 46 (33) ◽  
pp. 9388-9398 ◽  
Author(s):  
Nigora Mukhamedova ◽  
Ying Fu ◽  
Michael Bukrinsky ◽  
Alan T. Remaley ◽  
Dmitri Sviridov
Keyword(s):  
Cholesterol Efflux ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

ATP-binding cassette transporter A1: regulation of cholesterol efflux

2004 ◽  
Vol 32 (1) ◽  
pp. 124-127 ◽  
Author(s):  
B.L. Knight
Keyword(s):  
Cholesterol Efflux ◽  
Cholesterol Metabolism ◽  
Dietary Cholesterol ◽  
Density Lipoprotein ◽  
Cholesterol Absorption ◽  
Apolipoprotein A1 ◽  
Whole Body ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells. Mutations in ABCA1 give rise to familial high-density lipoprotein (HDL) deficiency and Tangier disease, which is characterized by very low levels of HDL in plasma and cholesteryl ester accumulation in tonsils and other reticuloendothelial cells. The mechanism of action of ABCA1 is still unclear, but requires the transfer of phospholipid and cholesterol to apolipoprotein A1 bound by or close to the transporter. An important factor in the regulation of ABCA1 is cholesterol itself, which provides oxysterol ligands for liver X receptors that stimulate ABCA1 transcription. ABCA1-deficient mice show increased cholesterol absorption, suggesting that ABCA1 could also help to transport dietary cholesterol back out of intestinal absorptive cells into the lumen. Thus ABCA1 is intimately connected to various aspects of the regulation of whole-body cholesterol metabolism and probably plays an important role in protecting against the development of cardiovascular disease.

Sign in / Sign up

Export Citation Format

Share Document