scholarly journals Effect of Xenon Treatment on Gene Expression in Brain Tissue after Traumatic Brain Injury in Rats

2021 ◽  
Vol 11 (7) ◽  
pp. 889
Author(s):  
Anton D. Filev ◽  
Denis N. Silachev ◽  
Ivan A. Ryzhkov ◽  
Konstantin N. Lapin ◽  
Anastasiya S. Babkina ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Tissue ◽  
Target Genes ◽  
Neural Function ◽  
Stress Genes ◽  
Expression Of Genes ◽  
Delayed Recovery ◽  
The Brain ◽  
Lower Expression

The overactivation of inflammatory pathways and/or a deficiency of neuroplasticity may result in the delayed recovery of neural function in traumatic brain injury (TBI). A promising approach to protecting the brain tissue in TBI is xenon (Xe) treatment. However, xenon’s mechanisms of action remain poorly clarified. In this study, the early-onset expression of 91 target genes was investigated in the damaged and in the contralateral brain areas (sensorimotor cortex region) 6 and 24 h after injury in a TBI rat model. The expression of genes involved in inflammation, oxidation, antioxidation, neurogenesis and neuroplasticity, apoptosis, DNA repair, autophagy, and mitophagy was assessed. The animals inhaled a gas mixture containing xenon and oxygen (ϕXe = 70%; ϕO2 25–30% 60 min) 15–30 min after TBI. The data showed that, in the contralateral area, xenon treatment induced the expression of stress genes (Irf1, Hmox1, S100A8, and S100A9). In the damaged area, a trend towards lower expression of the inflammatory gene Irf1 was observed. Thus, our results suggest that xenon exerts a mild stressor effect in healthy brain tissue and has a tendency to decrease the inflammation following damage, which might contribute to reducing the damage and activating the early compensatory processes in the brain post-TBI.

scholarly journals Transient brain stem ischemia following cervical spine surgery: An unusual cause of delayed recovery

2014 ◽  
Vol 30 (3) ◽  
pp. 432 ◽  
Author(s):  
Nirmala Jonnavithula ◽  
Kavya Cherukuri ◽  
Padmaja Durga ◽  
DilipKumar Kulkarni ◽  
Vijayasaradhi Mudumba ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Brain Stem ◽  
Spine Surgery ◽  
Cervical Spine Surgery ◽  
Delayed Recovery ◽  
Brain Stem Ischemia

Hemodynamic Mechanisms Underlying Initial Orthostatic Hypotension, Delayed Recovery and Orthostatic Hypotension

2018 ◽  
Vol 19 (9) ◽  
pp. 786-792 ◽  
Author(s):  
Veera K. van Wijnen ◽  
Dik Ten Hove ◽  
Ciarán Finucane ◽  
Wouter Wieling ◽  
Arie M. van Roon ◽  
...  
Keyword(s):  
Orthostatic Hypotension ◽  
Delayed Recovery ◽  
Initial Orthostatic Hypotension

Myocardial ischemia and delayed recovery after anesthesia in a patient with Cockayne syndrome: A case report

2001 ◽  
Vol 59 (12) ◽  
pp. 1488-1491 ◽  
Author(s):  
Man K. Yuen ◽  
M.R. Chandra Rodrigo ◽  
J.Claude Law Min ◽  
C.K. Antonio Tong
Keyword(s):  
Case Report ◽  
Myocardial Ischemia ◽  
Cockayne Syndrome ◽  
Delayed Recovery

scholarly journals WORKING THE NIGHT SHIFT CAUSES INCREASED VASCULAR STRESS AND DELAYED RECOVERY IN YOUNG WOMEN

2010 ◽  
Vol 27 (7) ◽  
pp. 1454-1468 ◽  
Author(s):  
Shih-Hsiang Lo ◽  
Lian-Yu Lin ◽  
Jing-Shiang Hwang ◽  
Yu-Yin Chang ◽  
Chiau-Suong Liau ◽  
...  
Keyword(s):  
Young Women ◽  
Night Shift ◽  
Delayed Recovery
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