scholarly journals Changes of the intestinal microbiota during chronic alcohol intake

2017 ◽  
Vol 6 (3) ◽  
pp. 64-67
Author(s):  
Anatoly Trofimovich Yakovlev ◽  
Sergey Viktorovich Poroysky ◽  
Liliya Petrovna Knyshova ◽  
Evgeny Igorevich Morkovin
Keyword(s):  
Alcohol Dependence ◽  
Intestinal Microbiota ◽  
Mineral Metabolism ◽  
Chronic Alcoholism ◽  
Clinical Results ◽  
Quantitative Composition ◽  
Chronic Alcoholic ◽  
Alcoholic Intoxication ◽  
Personalized Approach ◽  
Chronic Alcoholic Intoxication

This paper examines the influence of chronic alcoholic intoxication on the qualitative and quantitative composition of the intestinal microbiota in patients with syndrome of alcohol dependence. The authors describe chronic alcoholic intoxication, accompanied by significant violations of homeostasis, which is manifested by changes in protein, carbohydrate, lipid, and mineral metabolism. The authors examine the role of alcohol as one of the main factors that affect dysbiotic shifts in the normal microbiota of human intestines. The paper presents the results of the comparison found earlier in the course of experimental work, significant changes of the intestinal microbiota of rats subjected to chronic alcoholism and clinical results of the study of the microbial landscape in patients with syndrome of alcohol dependence. The authors established that under the influence of alcohol there is a statistically significant reduction in saccharolytic microbiota. The obtained data are a part of a clinic-experimental study of changes in the state of resistance of the organism exposed to the chronic effects of alcohol and can serve as a basis for further study of the intestinal microbiota changes, which is an important component of a personalized approach to the definition of tactics of treatment and rehabilitation of people with the syndrome of alcohol dependence.

THE EFFECT OF REPEATED ALCOHOLIC INTOXICATION ON ADRENAL ASCORBIC ACID AND CHOLESTEROL IN THE RAT

1962 ◽  
Vol 40 (8) ◽  
pp. 975-981 ◽  
Author(s):  
H. Kalant ◽  
Caroline Czaja
Keyword(s):  
Ascorbic Acid ◽  
Relative Weight ◽  
Ascorbic Acid Content ◽  
Female Rats ◽  
Male Rats ◽  
Albino Rats ◽  
Chronic Alcoholic ◽  
Alcoholic Intoxication ◽  
Chronic Alcoholic Intoxication ◽  
Inclined Plane Test

Groups of adult male and female albino rats received daily gavage of 1.25 ml of water or of 20% ethanol per 100 g body weight for a period of 1 month, and were killed either 1.5 hours or 24 hours after the last dose. Such daily treatment with either water or alcohol, ending 24 hours before death, did not result in any significant change from control values in the relative weight of the adrenal glands, or their ascorbic acid and cholesterol contents. No changes in these values were found in animals which received an additional dose of water or alcohol 1.5 hours before death. The female rats showed lower values for adrenal ascorbic acid content than the males in corresponding groups, but did not differ from the males with respect to the effects of the various treatments. A similar experiment with male rats only, carried on for 2 months, also showed no significant differences among any of the treatment groups.Measurements of the degree of intoxication produced by single doses of ethanol were carried out by means of the inclined-plane test. Intraperitoneal injection of 2 g/kg produced much more rapid and marked intoxication than did gavage with either 2 or 4 g/kg.It was concluded that daily gavage for 1-2 months with ethanol in a moderately intoxicating dose (2 g/kg) does not constitute a stimulus to adrenal cortical activity or result in exhaustion atrophy of the adrenal cortex, and that adrenal cortical stimulation is not an invariable accompaniment of acute or chronic alcoholic intoxication.

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