scholarly journals Photodynamic therapy in combined treatment of cholangiocellular carcinoma (case report)

2020 ◽  
Vol 39 (3) ◽  
pp. 96-99
Author(s):  
Sergey A. Alentyev ◽  
Bogdan N. Kotiv ◽  
Dmitriy P. Shershen ◽  
Dmitry Boyarinov ◽  
Darya Y. Plotnikova ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Case Report ◽  
Survival Rate ◽  
Minimally Invasive ◽  
Combined Treatment ◽  
Locally Advanced ◽  
Regional Chemotherapy ◽  
Cholangiocellular Carcinoma ◽  
Extended Surgery ◽  
Cholangiocellular Cancer

In this article a case report of an effective combined treatment of a patient with locally advanced cholangiocellular cancer who underwent neoadjuvant regional chemotherapy, extended surgery, adjuvant regional chemotherapy, as well as a set of minimally invasive endoscopic and percutaneous endobiliary techniques, which allowed the progression of the disease, including to increase the patients survival rate is presented. (5 figs, bibliography: 5 refs).

COMBINED TREATMENT FOR KLATSKIN NON-RESECTABLE TUMOR USING INTRA-FLOW PHOTODYNAMIC THERAPY AND REGIONAL CHEMOTHERAPY

2018 ◽  
Vol 64 (4) ◽  
pp. 485-489
Author(s):  
Vladimir Polysalov ◽  
Dmitriy Granov ◽  
A. Gapbarov ◽  
A. Polekhin
Keyword(s):  
Photodynamic Therapy ◽  
Survival Rate ◽  
Radiation Power ◽  
Combined Treatment ◽  
Celiac Trunk ◽  
Regional Chemotherapy ◽  
Response To Treatment ◽  
Dose Fractionation ◽  
Klatskin Tumor ◽  
Average Life Span

The experience of treatment of 28 patients with Klatskin tumor is summarized. Bile ducts tumor of stages III-IV was diagnosed in 25 patients. A total of 97 sessions of intra-flow photodynamic therapy and 74 courses of regional chemotherapy were conducted. One patient due to a full response to treatment there was performed orthotopic liver transplantation from a cadaver donor. In all observations the diagnosis was confirmed morphologically by means of intraflow biopsy or after investigation of the removed specimen. All patients at the time of the beginning of treatment underwent percutaneous cholangiodrainage. Intra-flow photodynamic therapy was performed in the dose-fractionation mode by the “LAKHTA-MILON” diode laser device using quartz optic fiber systems and a catheter with a cylindrical diffuser at a radiation power at the fiber output of one watt. The density of the supplied energy was 200 J/cm2. Radachlorin or Photon preparations were used as photosensitizers. Subsequently, in 2-4 days, visceral angiography of the hepatopancreatoduodenal zone with the arterial catheter inserted into the celiac trunk or the common hepatic artery to carry out regional chemotherapy by GemOx mode was performed. 21 (71,4%) patients died at the time from 8 to 42 months. 7 (28.6%) patients who undergo repeated courses of combined treatment at intervals of 1,5 to 3 months are alive and under observation from 10 to 26 months. The median survival is 21 months, the average life span is 15,4 + 0,8 months. A one-year survival rate is 78%, a two-year survival rate - 18%, a three-year survival rate - 4%. Survival of patients (according to Kaplan-Meier) is 18 months.

scholarly journals Personalised approach in combined treatment of cholangiocarcinoma: a case report of healing from cholangiocellular carcinoma at stage IV

2019 ◽  
Vol 10 (4) ◽  
pp. 815-820 ◽  
Author(s):  
Timur Bunyatov ◽  
Alexey Zhao ◽  
Juriy Kovalenko ◽  
Beslan Gurmikov ◽  
Vladimir Vishnevsky
Keyword(s):  
Case Report ◽  
Combined Treatment ◽  
Stage Iv ◽  
Cholangiocellular Carcinoma

scholarly journals Tumor irradiation combined with minimally invasive surgery (vascular-targeted photodynamic therapy) enhances anti-tumour effects in preclinical prostate cancer

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Hannah Sjoberg
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Vascular Function ◽  
Locally Advanced ◽  
Tumour Microenvironment ◽  
Proof Of Concept ◽  
Fractionated Radiotherapy ◽  
Tumour Control ◽  
Targeted Photodynamic Therapy

Hanna T Sjoberg, Yiannis Philippou, Anette L Magnussen, Iain DC Tullis, Esther Bridges, Andrea Chatrian, Joel Loefebvre, Ka Ho Tam, Emma A Murphy, Jens Rittscher, Dina Preise, Lilach Agemy, Tamar Yechezkel, Sean C Smart, Paul Kinchesh, Stuart Gilchrist, Danny P Allen, David A Scheiblin, Stephen J Lockett, David A Wink, Alastair D Lamb, Ian G Mills, Adrian Harris, Ruth J Muschel, Boris Vojnovic, Avigdor Scherz, Freddie C Hamdy, Richard J Bryant.   Introduction There is an important clinical need to improve the treatment of high risk localised and locally advanced prostate cancer (PCa), and to reduce the side effects of these treatments. We hypothesised that multi-modality therapy combining radiotherapy and vascular-targeted photodynamic therapy (VTP) could PCa tumour control compared against monotherapy with each of these treatments alone. This could provide proof-of-concept to take to the clinic. VTP is a minimally invasive focal surgical therapy for localised PCa, which rapidly destroys targeted tumours through vascular disruption. Tumour vasculature is characterised by vessel immaturity, increased permeability, aberrant branching and inefficient flow. Fractionated radiotherapy (FRT) alters the tumour microenvironment and promotes transient vascular normalisation. Materials and Methods We investigated whether sequential delivery of FRT followed by VTP 7 days later improves PCa tumour control compared to monotherapy with FRT or VTP alone. Results FRT induced vascular normalisation changes in PCa flank tumour allografts, improving vascular function as demonstrated using dynamic contrast enhanced magnetic resonance imaging. FRT followed by VTP significantly delayed tumour growth in flank PCa allograft pre-clinical models, compared with monotherapy with FRT or VTP alone, and improved overall survival. Conclusion Taken together, these results suggest that combining FRT and VTP could become a promising multimodal clinical strategy in PCa therapy. This provides proof-of-concept for this multi-modality therapy approach to take forward to early phase clinical trials.

Results of Combined Treatment of Patients with Locally Advanced Breast Cancer

1983 ◽  
Vol 69 (3) ◽  
pp. 249-253 ◽  
Author(s):  
Marek Pawlicki ◽  
Jan Skolyszewski ◽  
Anna Brandys
Keyword(s):  
Breast Cancer ◽  
Survival Rate ◽  
Inflammatory Breast Cancer ◽  
Systemic Treatment ◽  
Locally Advanced Breast Cancer ◽  
Combined Treatment ◽  
Locally Advanced ◽  
Local Treatment ◽  
Remission Induction ◽  
Maintenance Chemotherapy

Eighty-seven women with previously untreated locally advanced, inoperable breast cancer were treated by induction chemotherapy combined with subsequent local and systemic treatment. Inflammatory breast cancer was diagnosed in 72 (87.7%) of these patients. In the remaining 15 patients, cancer of the breast in stage T3-4 N2b-3 according to the UICC classification was diagnosed. After remission induction, the patients were irradiated or operated upon. Maintenance chemotherapy was given after local treatment. The 3-year survival rate (61.5%) in the group of patients treated by surgery was significantly higher than the patients treated by irradiation (32.4%) or chemotherapy alone (12.5%). On this basis, a new program of treatment of locally advanced, inoperable breast cancer has been proposed.

scholarly journals Successful Extensive Multiorgan Resection of Malignant Duodenal Tumor: A Case Report

2020 ◽  
Vol 18 (1) ◽  
pp. 36-38
Author(s):  
Ilva Spiridonova ◽  
Armands Sīviņš
Keyword(s):  
Overall Survival ◽  
Case Report ◽  
Surgical Treatment ◽  
Survival Rate ◽  
Late Stage ◽  
Locally Advanced ◽  
Overall Survival Rate ◽  
Duodenal Adenocarcinoma ◽  
Gastrointestinal Malignancies ◽  
Duodenal Tumor

SummaryDuodenal adenocarcinoma is one of the rarest tumours of all gastrointestinal malignancies. Due to rarity and late symptoms, duodenal cancers are diagnosed in late stage, but overall survival rate is high. We present a case of locally advanced duodenal adenocarcinoma with successful surgical treatment including multiorgan resection.

scholarly journals Combined treatment for locally advanced cholangiocellular liver cancer - the case report

2019 ◽  
Vol 6 (4) ◽  
pp. 158-167
Author(s):  
A. N. Polyakov ◽  
Yu. I. Patyutko ◽  
A. Yu. Syskova ◽  
K. A. Romanova ◽  
I. S. Bazin ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Cancer ◽  
Combined Treatment ◽  
Locally Advanced

scholarly journals Locally Advanced Bladder Paraganglioma Managed with Robot-assisted Radical Cystectomy with Intracorporeal Neobladder- A Case Report

2021 ◽  
Author(s):  
Anoop Handa ◽  
Sharat Chandra Dash ◽  
Nimit Solanki ◽  
Gagandeep Singh
Keyword(s):  
Minimally Invasive Surgery ◽  
Case Report ◽  
Minimally Invasive ◽  
Radical Cystectomy ◽  
Invasive Surgery ◽  
Neuroendocrine Tumours ◽  
Locally Advanced ◽  
Robot Assisted ◽  
Ileal Neobladder ◽  
Primary Bladder

Paragangliomas are neuroendocrine tumours of extra-adrenal origin. Primary bladder paragangliomas are rare and have variable functional status, which presents a challenge in their management by minimally invasive surgery. Surgical resection necessitates minimal intraoperative handling of tumour, minimising physiological deterioration. Here in, a case is reported of incidentally detected locally advanced bladder paraganglioma which was managed successfully with robot-assisted radical cystectomy and intracorporeal ileal neobladder formation.

Minimally Invasive Approach for Wilms Tumor Treatment in a Small Child - A Case Report

Urology ◽  
2020 ◽  
Author(s):  
Alexandre Azevedo Ziomkowski ◽  
João Rafael Silva Simões Estrela ◽  
Nilo Jorge Carvalho Leão Barretto ◽  
Nilo César Leão Barretto
Keyword(s):  
Case Report ◽  
Minimally Invasive ◽  
Wilms Tumor ◽  
Small Child ◽  
Tumor Treatment ◽  
Minimally Invasive Approach ◽  
Invasive Approach

A Case of Catatonia in a 14-Year-Old Girl with Schizophrenia Treated with Electroconvulsive Therapy

2013 ◽  
Vol 41 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Frank Häßler ◽  
Olaf Reis ◽  
Steffen Weirich ◽  
Jacqueline Höppner ◽  
Birgit Pohl ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Response ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Combined Treatment ◽  
Adolescent Patient

This article presents a case of a 14-year-old female twin with schizophrenia who developed severe catatonia following treatment with olanzapine. Under a combined treatment with amantadine, electroconvulsive therapy (ECT), and (currently) ziprasidone alone she improved markedly. Severity and course of catatonia including treatment response were evaluated with the Bush-Francis Catatonia Rating Scale (BFCRS). This case report emphasizes the benefit of ECT in the treatment of catatonic symptoms in an adolescent patient with schizophrenic illness.

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