scholarly journals Antioxidant activity of catecholamines as a chane of them antistress effect

2014 ◽  
Vol 12 (2) ◽  
pp. 43-46 ◽  
Author(s):  
Georgii Nolianovich Shilov ◽  
Vladislav Adamovich Ivanyutin
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Brain Cortex ◽  
Malonic Dialdehyde ◽  
Receptor Activation ◽  
Antioxidant Effect ◽  
Water Soluble ◽  
Antioxidant Mechanism ◽  
Antistress Effect ◽  
The Brain

The antioxidant activity of some native catecholamines (adrenaline, noradrenaline, dopamine), water-soluble antioxidant emoxipine, agonist (apomorphine) and antagonist (haloperidol) of dopamine receptors was assessed as their influence on malonic dialdehyde content and products of lipid peroxidation in homogenates and suspension of the rat cortical brain cells. All catecholamines (adrenaline, noradrenaline, dopamine in concentrations of 10-4 M and 10-5 M) possessed a high (compartable with emoxipine) antioxidant activity. The most antioxidant effect was registered in apomorphine. The inhibitory action of apomorphine on lipid peroxidation in the brain cortex can be a result from both dopamine receptor activation and “direct” antioxidant mechanism.

Trace Element, Antioxidant Activity, and Lipid Peroxidation Levels in Brain Cortex of Gerbils After Cerebral Ischemic Injury

2013 ◽  
Vol 152 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Kwang-Ming Fang ◽  
Fu-Chou Cheng ◽  
Yeou-Lih Huang ◽  
Shu-Ying Chung ◽  
Zhong-Yang Jian ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Trace Element ◽  
Brain Cortex ◽  
Ischemic Injury ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

scholarly journals Hypoxia-Induced Lipid Peroxidation in the Brain During Postnatal Ontogenesis

2012 ◽  
pp. S89-S101 ◽  
Author(s):  
H. RAUCHOVÁ ◽  
M. VOKURKOVÁ ◽  
J. KOUDELOVÁ
Keyword(s):  
Lipid Peroxidation ◽  
Hypobaric Hypoxia ◽  
Brain Cortex ◽  
Membrane Lipids ◽  
High Rate ◽  
Subcortical Structures ◽  
Short Term ◽  
Adult Rats ◽  
Lactate Dehydrogenase Activity ◽  
The Brain

Reactive oxygen species (ROS) are common products of the physiological metabolic reactions, which are associated with cell signaling and with the pathogenesis of various nervous disorders. The brain tissue has the high rate of oxidative metabolic activity, high concentration of polyunsaturated fatty acids in membrane lipids, presence of iron ions and low capacity of antioxidant enzymes, which makes the brain very susceptible to ROS action and lipid peroxidation formation. Membranes of brain cortex show a higher production of thiobarbituric acid-reactive substances (TBARS) in prooxidant system (ADP.Fe3+/NADPH) than membranes from the heart or kidney. Lipid peroxidation influences numerous cellular functions through membrane-bound receptors or enzymes. The rate of brain cortex Na+,K+-ATPase inhibition correlates well with the increase of TBARS or conjugated dienes and with changes of membrane fluidity. The experimental model of short-term hypoxia (simulating an altitude of 9000 m for 30 min) shows remarkable increase in TBARS in four different parts of the rat brain (cortex, subcortical structures, cerebellum and medulla oblongata) during the postnatal development of Wistar rat of both sexes. Young rats and males are more sensitive to oxygen changes than adult rats and females, respectively. Under normoxia or hypobaric hypoxia both ontogenetic aspects and sex differences play a major role in establishing the activity of erythrocyte catalase, which is an important part of the antioxidant defense of the organism. Rats pretreated with L-carnitine (and its derivatives) have lower TBARS levels after the exposure to hypobaric hypoxia. The protective effect of L-carnitine is comparable with the effect of tocopherol, well-known reactive species scavenger. Moreover, the plasma lactate increases after a short-term hypobaric hypoxia and decreases in L-carnitine pretreated rats. Acute hypobaric hypoxia and/or L-carnitine-pretreatment modify serum but not brain lactate dehydrogenase activity. The obtained data seem to be important because the variations in oxygen tension represent specific signals of regulating the activity of many specific systems in the organism.

scholarly journals A DIFFERENTIATED APPROACH TO INFUSION-TRANSFUSION THERAPY FOR LARGE BLOOD LOSS IN PATIENTS WITH POLYTRAUMA

World Science ◽  
2021 ◽  
Author(s):  
Tyhai Yuliia ◽  
Mykhnevych Kostiantyn
Keyword(s):  
Lipid Peroxidation ◽  
Blood Loss ◽  
Malonic Dialdehyde ◽  
Antioxidant Effect ◽  
Blood Levels ◽  
Energy Status ◽  
Transfusion Therapy ◽  
Oxygen Transport System ◽  
Grade Iii ◽  
Pyruvate Ratio

With polytrauma, more than 30% of victims are diagnosed with severe blood loss, grade III MARINO of the leading components is transfusion therapy, which aims to restore the erythron system and improve the functional state of the oxygen transport system. The addition to intensive care of substances that affect lipid peroxidation and energy status of cells can reduce the number of heterogeneous transfusions and thus reduce the number of complications in the postoperative period. Such substances may be a solution of ceruloplasmin with a leading antioxidant effect and a solution of D-fructose-1,6-diphosphate sodium salt of the hydrate with an energetic effect. Criteria for exposure to these substances should be indicators such as blood levels of hemoglobin, phosphorus, malonic dialdehyde and lactate / pyruvate ratio.

scholarly journals Antioxidative Properties of Melanins and Ommochromes from Black Soldier Fly Hermetia illucens

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 408 ◽  
Author(s):  
Nina Ushakova ◽  
Alexander Dontsov ◽  
Natalia Sakina ◽  
Alexander Bastrakov ◽  
Mikhail Ostrovsky
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Acid Hydrolysis ◽  
Antiradical Activity ◽  
Antioxidant Properties ◽  
Water Soluble ◽  
Black Soldier Fly ◽  
Natural Pigments ◽  
Luminol Chemiluminescence ◽  
Spin Resonance

A comparative study of melanin and ommochrome-containing samples, isolated from the black soldier fly (BSF) by enzymatic hydrolysis, alkaline and acid alcohol extraction or by acid hydrolysis, was carried out. Melanin was isolated both as a melanin-chitin complex and as a water-soluble melanin. Acid hydrolysis followed by delipidization yielded a more concentrated melanin sample, the electron spin resonance (ESR) signal of which was 2.6 × 1018 spin/g. The ommochromes were extracted from the BSF eyes with acid methanol. The antiradical activity of BSF melanins and ommochromes was determined by the method of quenching of luminol chemiluminescence. It has been shown that delipidization of water-soluble melanin increases its antioxidant properties. A comparison of the antioxidant activity of BSF melanins and ommochromes in relation to photoinduced lipid peroxidation was carried out. The ESR characteristics of native and oxidized melanins and ommochromes were studied. It is assumed that H. illucens adult flies can be a useful source of natural pigments with antioxidant properties.

scholarly journals THE CONDITION OF THE LIPOPEROXIDATION SYSTEM IN PREMATURE NEWBORNS AFTER PERINATAL HYPOXIA

2018 ◽  
Vol 63 (5) ◽  
pp. 135-138 ◽  
Author(s):  
E. V. Loskutova ◽  
I. A. Vorontsova ◽  
H. M. Vahitov ◽  
I. H. Valeeva ◽  
O. I. Polyakova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Malonic Dialdehyde ◽  
Perinatal Hypoxia ◽  
Antioxidant Protection ◽  
Premature Newborns ◽  
Gestation Age ◽  
Total Antioxidant ◽  
Oxidative Protection ◽  
Premature Children

Objective:to determine the role of the indicators of lipid peroxidation and antioxidant protection in the pathogenesis of perinatal hypoxia in premature newborns.Methods. The authors studied two groups of premature newborns: 24 infants born at 34-36 weeks of gestation (late premature children), and 7 children with gestation age of 32-34 weeks (moderately premature children). The authors assessed the levels of ceruloplasmin, total antioxidant activity and malonic dialdehyde in the blood serum.Results.Comparison of the studied indicators revealed higher levels of antioxidant protection and malonic dialdehyde in late premature newborns, which can be associated with greater activity of metabolic processes and resistance to oxidative stress in this group.The authors studiedsuch factors as the sex of the child and the degree of asphyxia at birth and their impact on the values of lipid peroxidation and antioxidant activity. They found that the male infants had a significant increase in the level of ceruloplasmin and antioxidant activity in comparison with the female infants. The children with moderate asphyxia at birth had the highest values of malonic dialdehyde and anti-oxidative protection.Conclusion.The processes of lipoperoxidation and antioxidant protection are optimally balanced in late premature infants, thus, we believe that they better adapted in conditions of hypoxia.

ECOLOGICAL AND HYGIENIC INVESTIGATION OF THE ADAPTOGENIC HERBAL PRODUCTS TO INCREASE RESISTANCE OF THE ORGANISM TO CONDITIONS OF LOW AND HIGH TEMPERATURES

2016 ◽  
Vol 1 (61) ◽  
pp. 46-51
Author(s):  
Литовченко ◽  
Ekaterina Litovchenko ◽  
Коршунова ◽  
Natalya Korshunova ◽  
Доровских ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
High Temperatures ◽  
Malonic Dialdehyde ◽  
Antioxidant Effect ◽  
The Body ◽  
Diene Conjugates ◽  
Herbal Products ◽  
Experimental Animals ◽  
White Rats ◽  
Methodological Approaches

The purpose of this research was to study the possibility of using of food products from a mixture of Hypericum perforatum (HP) and Rhodiola rosea (RR) for the stimulation of the body´s compensatory responses to the conditions of high and low temperatures. Experiments have been conducted on experimental animals (150 white mongrel rats) in accordance with generally accepted methodological approaches. Antioxidant effects in the organism of white rats have been studied at the initiation of the processes of lipid peroxidation by the introduction of carbon tetrachloride. We were determined the products of lipid peroxidation (diene conjugates, hydroperoxides of lipids, malonic dialdehyde) for the evaluation of antioxidant effect in accordance with generally accepted methodological approaches. Researches of cold and heat adaptation reactions of experimental animals have been conducted by using the model of a long cold and heat action with appropriate climatic chambers. It was established experimentally that in doses of 150-300 mg/kg daily of the studied mixture has a strong antioxidant effect in the conditions of cold and heat stress on warm-blooded organism. The research allows to recommend a mixture of HP and RR as а regulator of adaptive reactions of the organism when exposed to low and high temperatures.

scholarly journals CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS

2018 ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Blood Plasma ◽  
Glutathione Reductase ◽  
Antioxidant System ◽  
Infectious Mononucleosis ◽  
Malonic Dialdehyde

The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

Effects of 17β-estradiol and antioxidant administration on oxidative stress and insulin resistance in ovariectomized rats

2011 ◽  
Vol 89 (7) ◽  
pp. 497-504 ◽  
Author(s):  
Amr M. Abbas ◽  
Ayman Z. Elsamanoudy
Keyword(s):  
Insulin Resistance ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Vitamin E ◽  
Brain Cortex ◽  
Fasting Glucose ◽  
Ovariectomized Rats ◽  
Ovx Rats ◽  
17Β Estradiol ◽  
The Brain

The prevalence of insulin resistance syndrome increases during menopause with the overproduction of reactive oxygen species and impairment of the free radical scavenger function. Therefore, we investigated the effects of 17β-estradiol (E2) and vitamin E, as an antioxidant, on lipid peroxidation and antioxidant levels in the brain cortex and liver of ovariectomized rats as well as on insulin resistance in those rats. Forty female Sprague–Dawley rats, 3 months of age and weighing 231.5 ± 9.4 g, were divided into 4 groups: sham, ovariectomized (OVX), OVX treated with E2 (40 µg/kg subcutaneously), and OVX treated with E2 and vitamin E (100 mg/kg intraperitoneally). The 4 groups received the appropriate treatment every day for 8 weeks. Levels of glutathione, glutathione peroxidase, superoxide dismutase , catalase, and malondialdehyde in the brain cortex and liver of ovariectomized rats were measured. Also, fasting plasma insulin, glucose, and homeostatis model assessment of insulin resistance (HOMA-IR) were determined. Malondialdehyde increased and antioxidants (glutathione, glutathione peroxidase, catalase, superoxide dismutase) decreased in the brain cortex and liver of OVX rats. Also, fasting glucose, insulin, and HOMA-IR increased in OVX rats. E2 and E2 plus vitamin E decreased malondialdehyde and increased antioxidants in the brain cortex and liver of OVX rats. Moreover, they decreased fasting glucose, insulin, and HOMA-IR in ovariectomized rats. This study demonstrates that E2 and E2 plus vitamin E supplementation to OVX rats may improve insulin resistance, strengthen the antioxidant system, and reduce lipid peroxidation.

Concentration-dependent effects of dietary L-ascorbic acid fortification in the brain of healthy mice

2021 ◽  
Vol 21 ◽  
Author(s):  
Anthony T. Olofinnade ◽  
Adejoke Y. Onaolapo ◽  
Olakunle J. Onaolapo
Keyword(s):  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Open Field ◽  
Antioxidant Status ◽  
Acetylcholinesterase Activity ◽  
Water Soluble ◽  
Nutritional Deficiencies ◽  
Apoptotic Markers ◽  
Behavioural Tests ◽  
The Brain

Background: Ascorbic acid (AA) is a water soluble vitamin which is concentrated in the brain in large quantities. While there have been reports that it is essential for proper brain functioning, there is a dearth of information on the possible effects dietary fortification with AA on the brain in health. Objective: This study examined the effects of dietary fortification of rodent chow with AA on neurobehaviour, antioxidant status, lipid peroxidation, and inflammatory/apoptotic markers in the brain of healthy mice. Method: Mice were randomly-assigned into four groups of ten animals each. Groups were normal control [fed rodent chow] and three groups fed AA-fortified chow at 100, 200 and 300 mg/kg of feed respectively, for eight weeks. Behavioural tests Open field, Y-maze, radial-arm maze, and elevated plus maze (EPM) were carried out on day 57. Twenty-four hours after the last behavioural test, animals were euthanised and the brains were excised and homogenised for assessment of brain acetylcholinesterase activity, lipid peroxidation, antioxidant status, inflammatory and apoptotic markers. Results: Ascorbic acid fortified diet was associated with concentration-dependent changes in body weight, open-field behaviours, working-memory, and anxiety indices. Also, brain levels of malondialdehyde, caspase-3, and TNF-α decreased; while superoxide dismutase activity, total antioxidant capacity and IL-10 level increased. Conclusion: Dietary AA fortification with concentrations up to 300 mg/kg of feed was associated with sustained improvement in neurobehavioural and biochemical parameters in the brain of healthy mice reiterating additional health benefits of AA fortification beyond the prevention of nutritional deficiencies.

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