scholarly journals Endoscopic technologies in treatment 7-month-old child with multiple laryngeal cysts

2021 ◽  
Vol 10 (2) ◽  
pp. 193-198
Author(s):  
Abdumanap B. Alkhasov ◽  
Elena Yu. Dyakonova ◽  
Maxim M. Lokhmatov ◽  
Yuri Yu. Rusetsky ◽  
Sergey P. Yatsyk ◽  
...  
Keyword(s):  
Neonatal Intensive Care ◽  
Surgical Techniques ◽  
Upper Airway ◽  
Uneventful Recovery ◽  
Neonatal Intensive Care Units ◽  
Federal State ◽  
National Medical ◽  
The Russian Federation ◽  
Autonomous Institution ◽  
Invasive Techniques

Introduction. Subglottic cysts are a rare clinical entity among infants and children. The annual incidence of congenital laryngeal cysts is quoted as 1,82 per 100,000 live births. The majority of cases present in neonates born at the extremes of prematurity and invariably have been intubated and managed in neonatal intensive care units. Clinically, the pathology manifested as upper airway obstruction, stridor, and dysphonia. Various surgical techniques have been proposed for the treatment of patients with laryngeal cysts. In a large percentage of cases, tracheostomy is required, especially in patients with large cysts due to the development of symptoms of respiratory failure. Purpose. The aim of this study is to demonstrate that endoscopic technologies in the treatment of laryngeal cysts in children can be useful to avoid tracheostomy and lead to an uneventful recovery. Materials and methods. We present a clinical case of managing a 7-month-old child with multiple laryngeal cysts from the Department of Thoracic Surgery in the National Medical Research Center for Childrens Health Federal state autonomous institution of the Russian Federation Ministry of Health. Conclusion. In the presented case, we demonstrate that modern minimally invasive techniques to treat laryngeal cysts restore the lumen of the respiratory tract. facilitate the course of the postoperative period, achieve complete patient recovery, and avoid tracheostomy.

scholarly journals The role of globotriaosylsphingosine in the diagnosis of Fabry disease in Russian patients

2020 ◽  
pp. 81-82
Author(s):  
Н.Н. Мазанова ◽  
А.А. Пушков ◽  
А.В. Пахомов ◽  
А.Ю. Асанов ◽  
К.В. Савостьянов
Keyword(s):  
Fabry Disease ◽  
Initial Diagnosis ◽  
Federal State ◽  
National Medical ◽  
Pathogenic Variants ◽  
Medical Genomics ◽  
The Russian Federation ◽  
Gla Gene ◽  
Autonomous Institution

Болезнь Фабри (БФ), MIM 301500 - Х-сцепленное заболевание, обусловленное мутациями в гене GLA, который кодирует фермент α-галактозидазу А (α-гал А). В 2017 году в лаборатории молекулярной генетики и медицинской геномики «НМИЦ здоровья детей» Министерства Здравоохранения России был разработан и внедрен метод определения концентрации лизо-Гб3 для диагностики БФ. К настоящему времени нами исследовано 9830 образцов сухих пятен крови из различных регионов России, полученных от 8832 пациентов мужского пола и 998 женского пола, в возрасте от 12 до 70 лет. В результате проведенного исследования у 33 мужчин было выявлено снижение активности фермента, а у 31 из них - повышение концентрации лизо-Гб3, у этих мужчин были обнаружены патогенные варианты гена GLA, тогда как у двух оставшихся мужчин были найдены полиморфные варианты гена GLA, описанные ранее как аллели, обладающие псевдодефицитной активностью. Кроме того, были выявлены 2 женщины с повышенной концентрацией лизо-Гб3, у которых также были обнаружены патогенные варианты гена GLA, тогда как у 5 женщин с псевдодефицитными аллелями гена GLA концентрация лизо-Гб3 была в норме. Наше исследование продемонстрировало преимущество измерения концентрации биомаркера лизо-Гб3 по сравнению с определением активности фермента α-гал А для первичной диагностики мужчин с подозрением на БФ, a также возможность использования этого биомаркера для первичной диагностики женщин с подозрением на БФ. Fabry Disease (BF), MIM 301500 - X-linked disease caused by mutations in the GLA gene, which encodes the enzyme α-galactosidase A (α-gal A). In 2017, a method for determining the concentration of lyso-Gb3 for the diagnosis of FD was developed and introduced in the laboratory of molecular genetics and medical genomics of the “National Medical Research of Children’s Health Federal State Autonomous Institution of the Ministry of Health of the Russian Federation. To date, we have studied 9830 samples of dry blood spots from various regions of Russia, obtained from 8832 male and 998 female patients, aged 12 to 70 years. As a result of the study, a decrease in enzyme activity was detected in 33 men, and in 31 of them an increase in the concentration of lyso-Gb3, pathogenic variants of the GLA gene were found in these men, while the two remaining men found polymorphic variants of the GLA gene, previously described as alleles with pseudodeficiency activity. In addition, 2 women with an increased concentration of lyso-Gb3 were identified, in whom pathogenic variants of the GLA gene were also detected, while in 5 women with pseudo-deficient alleles of the GLA gene, the concentration of lyso-Gb3 was normal. Our study demonstrated the advantage of measuring the concentration of the lyso-Gb3 biomarker compared to determining the activity of the α-gal A enzyme for the initial diagnosis of men with suspected FD, as well as the possibility of using this biomarker for the initial diagnosis of women with suspected DF.

scholarly journals First experience using telemedicine technologies in ophthalmology of the Far Eastern Federal District of the Russian Federation

2021 ◽  
pp. 57-63
Author(s):  
O.V. Kolenko ◽  
◽  
M.V. Pshenichnov ◽  
E.L. Sorokin ◽  
M.G. Grekov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Federal District ◽  
State Institution ◽  
Federal State ◽  
Knowledge Transmission ◽  
High Demand ◽  
National Medical ◽  
Key Words Telemedicine ◽  
The Russian Federation ◽  
Far Eastern

Purpose. Evaluation of the first experience in organizing systematic telemedicine consultations/conciliums between the national medical research center and medical organizations in the territory of the Far Eastern Federal District (FEFD) of the Russian Federation. Material and methods. The analysis of organizational and technical difficulties in creating of stable system of planned and unscheduled telecommunication events between the Khabarovsk branch of the Fyodorov Eye Microsurgery Federal State Institution (Khabarovsk branch) and assigned to it medical organizations of the 3rd level, providing ophthalmological care for patients from 8 administrative territories of the FEFD. Results. Organizational and methodological department was created in the Khabarovsk branch, which clarified and eliminated the factors that impeded of telemedicine consultations/conciliums for ophthalmologists of medical organizations of the 3rd level; a set of organizational measures was taken to register these medical organizations in the Federal Register of Medical Organizations, in the Unified State Information System in the Field of Healthcare; the equipment necessary for communication was purchased and technically prepared; methodological assistance was provided in setting up equipment in the regions, including on-site visits; backup connections of several providers have been created; an algorithm for preliminary notification of regional ophthalmologists about the knowledge transmission has been worked out; an organizational algorithm for forming a request for telemedicine consultations has been tested. For 2019–2020 the Khabarovsk branch conducted 32 knowledge transmissions, 560 telemedicine consultations on patients living in the FEFD. Conclusion. The introduction into the daily clinical ophthalmologists practice in the FEFD of system of periodic telecommunication events between the Khabarovsk branch and assigned medical organizations of the 3rd level after the elimination of organizational and technical difficulties showed a high demand, allowing consultations on patient management in accordance with modern standards of ophthalmological care. Key words: telemedicine, teleophthalmology, Far Eastern Federal District, knowledge transmission, telemedicine consultations

scholarly journals Experience in Using Simulation Equipment in Teaching Transthoracic Echocardiography Skills

2021 ◽  
Vol 1 (3) ◽  
pp. 132-133
Author(s):  
Kh. A. Tengizov ◽  
S. V. Shahidzhanova ◽  
M. A. Saidova
Keyword(s):  
Medical Research ◽  
Russian Federation ◽  
Transthoracic Echocardiography ◽  
Research Center ◽  
Federal State ◽  
Ministry Of Health ◽  
National Medical ◽  
The Russian Federation

This paper describes the experience of teaching transthoracic echocardiography (TTE) skills on simulation equipment, accumulated over 2 years of training of residents in the direction of "Cardiology" at the Federal State Budgetary Institution "National Medical Research Center of Cardiology" of the Ministry of Health of the Russian Federation (Cardiocenter).

scholarly journals Preparation of the intestine for colonoscopy of women with reproductive system pathology

2019 ◽  
pp. 142-146
Author(s):  
T. A. Stoletova
Keyword(s):  
General Surgery ◽  
Reproductive Age ◽  
Federal State ◽  
Women Of Reproductive Age ◽  
Surgical Department ◽  
National Medical ◽  
The Russian Federation ◽  
Colon Preparation ◽  
Colonoscopy Preparation

Aim: to evaluate the efficacy of Picoprep for colonoscopy preparation in women with pelvic pathology.Patients and methods: during the period from January 2018 to December 2018 in the Federal State Budgetary Institution «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I.Kulakov’’ of the Ministry of Health of the Russian Federation, 873 diagnostic video-colonoscopies were performed on women of reproductive age (from 23 to 41 years of age) in the surgical department of the Department of Operational Gynecology and General Surgery. Macrogol and Picoprep were used in preparation for the study. 512 (58.7%) of the total number of performed colonoscopies were performed after colon preparation with Picoprep.Results: quality of colon preparation with Picoprep: excellent – 168 (32.7%), good – 275 (53.7%), satisfactory – 66 (13%), unsatisfactory – 3 (0.6%).Conclusion: The effectiveness of Picoprep does not differ from the quality of preparation with the use of alternative preparations of Macrogol, but significantly exceeds them in tolerability by patients.

Anterior Cricoid Split: A “Simple” Surgical Procedure and a Potentially Complicated Care Problem

1985 ◽  
Vol 94 (5) ◽  
pp. 445-449 ◽  
Author(s):  
Kenneth M. Grundfast ◽  
Avon C. Coffman ◽  
Gregory Milmoe
Keyword(s):  
Myocardial Infarction ◽  
Neonatal Intensive Care ◽  
Medical Center ◽  
Operative Procedure ◽  
Upper Airway ◽  
Assisted Ventilation ◽  
Airway Compromise ◽  
National Medical ◽  
Analysis Of Results ◽  
Experienced Team

The anterior cricoid split (ACS) has been described as an alternative to tracheotomy in management of the premature infant who develops upper airway compromise after extubation. Sixteen patients at the Children's Hospital National Medical Center (CHNMC) and ten patients at four other hospitals had the ACS operation. For the patients at the CHNMC, average gestational age was 29 weeks, birth weight was 1,264 g, and length of time intubated was 6.2 weeks. Overall success in achieving extubation after the ACS was 69% at the CHNMC and 40% for the group of other hospitals. However, a success rate in achieving extubation after ACS was 75% for both the CHNMC and the group of other hospitals in patients who had become stable enough to have been previously discharged from a neonatal intensive care unit. Problems encountered following the ACS include malposition of tip of the endotracheal tube, increased need for assisted ventilation, myocardial infarction, subcutaneous emphysema, and unexplained inability to ventilate. Analysis of results suggests that the ACS is a valuable operative procedure that can avoid need for tracheotomy in infants with adequate pulmonary function who have narrowing within the airway at the subglottic level. Postoperative care may be problematic and the infant having had the ACS is best managed by an experienced team of experts who are familiar with care of the infant with respiratory insufficiency.

scholarly journals Prevalence dynamics of uropatogens and antimicrobial resistance determinants in children's significant bacteriuria in 2017 and 2019: a monocenter study

2021 ◽  
Vol 20 (3) ◽  
pp. 11-17
Author(s):  
E. D. Shedko ◽  
A. V. Lazareva ◽  
S. N. Zorkin ◽  
I. E. Novikova ◽  
V. G. Vershinina ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Intestinal Flora ◽  
Federal State ◽  
Genetic Determinants ◽  
National Medical ◽  
Epidemiological Monitoring ◽  
Microbiological Methods ◽  
Autonomous Institution ◽  
Tract Infections

Urinary tract infections are the second most common infections in children with spreading of antimicrobial resistance among uropathogens currently poses a high epidemiological threat.Purpose. Analysis of species prevalence and the presence of genetic determinants of antibiotic resistance.Materials and methods. In the study 215 midstream urine samples were retrospectively analyzed. Samples were obtained during 2017 and 2019 from patients aged 4 weeks to 17 years at the National Medical Research Center for Children's Health Federal State Autonomous Institution of the Ministry of Health of the Russian Federation.Results. Species of pathogen were identified in 93 samples, while the bacterial composition of other samples was classified as «intestinal flora» (n = 17), «coccus flora» (n = 16) or «mixed flora» (n = 89). The most common types of uropathogens in monopathogenic infections in 2017 and 2019 were Escherichia coli (37.5% and 29.2%, respectively). Among infections caused by multiple pathogens, the most common etiological agents were Pseudomonas aeruginosa and Staphylococcus spp. Among all studied samples, 31.9% contained CTX-M-like genes, 5% VIM genes, 1.8% NDM genes, and 3.0% — OXA-48-like genes, and 5.6% of samples contained two and more genetic determinants associated with resistance, with the most prevalent gene combination being the combination of CTX-M- and OXA-48-like genes. In 69 samples with identified species of uropathogens, resistance profile to antimicrobial, determined by microbiological methods, correlated with detected resistance genetic determinants.Conclusion. Authors suggest that introduction of testing for the presence of genes associated with antibacterial resistance to general clinical practice would not only provide an opportunity to conduct epidemiological monitoring of the genetic determinants of antibiotic resistance, but also provide an opportunity to select the correct timely treatment of childhood bacteriuria caused by antibiotic-resistant infectious agents.

YENİDOĞAN YOĞUN BAKIM ÜNİTELERİNDE İŞ KAZALARI RİSKLERİ VE NEDENLERİNE YÖNELİK BİR ARAŞTIRMA

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Haluk Tanrıverdi ◽  
Orhan Akova ◽  
Nurcan Türkoğlu Latifoğlu
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Physical Environment ◽  
Neonatal Intensive Care ◽  
Organizational Factors ◽  
Occupational Accidents ◽  
Neonatal Intensive Care Units ◽  
Work Related ◽  
Physical Conditions ◽  
The Relationship

This study aims to demonstrate the relationship between the qualifications of neonatal intensive care units of hospitals (physical conditions, standard applications, employee qualifications and use of personal protective equipment) and work related causes and risks, employee related causes and risks when occupational accidents occur. Accordingly, a survey was prepared and was made among 105 nurses working in 3 public and 3 private hospital's neonatal intensive care units, in the January of 2010. The survey consists of questions about the qualifications of neonatal intensive care units, work related causes and risks, and employee related causes and risks. From the regression analysis conducted, it has been found that confirmed hypotheses in several studies in the literature were not significant in this study. The sub-dimensions in which relationships has been found show that the improvement of the physical environment in workplace, the improvement of the employee qualifications and standard applications can reduce the rate of occupational accidents. According to the results of this study management should take care of the organizational factors besides to improvement of the physical environment in workplace, the improvement of the employee qualifications and standard applications.

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