Characteristic features of lysocim influence on growth kinetics of candida albicans fungi
Aim.To assess the growth kinetics and biofilm-forming activity of Candida albicans strains when cultivated in nutrient medium with different concentrations of lysocim. Materials and methods. Growth kinetics of strains was determined by changes in optic density of suspension at 620 nm, and biofilms detected them by their staining with fuchsin. The results were registered on photometer. Results.Lysocim changes the growth kinetics of C. albicans, reducing the duration of exponential and prolonging the stationary phases of growth. It was established that increased lysocim concentration positively influences the proliferative activity of the fungi. As lysocim concentration is increased, C. albicans biofilm-forming activity is elevating. Conclusions. Thus, the increased level of lysocim contributes to transition of fungi into the plankton form of growth that should be taken into consideration when treating patients with candidiasis.