scholarly journals BATTERY OF TESTS FOR STUDYING THE ADAPTOGENIC EFFECTS OF BIOLOGICALLY ACTIVE SUBSTANCES IN PRE-CLINICAL TRIALS

2021 ◽  
Author(s):  
Evgeny B. Shustov ◽  
Sergey V. Okovityi ◽  
Vera Ts. Bolotova ◽  
Alexey E. Kim
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Preclinical Research ◽  
Nonspecific Resistance ◽  
Regulatory Pathways ◽  
Endogenous Regulators ◽  
Definition Of ◽  
Adaptation Processes ◽  
Adaptogenic Activity ◽  
Active Substances

The purpose of the article is to propose to researchers of the problems of adaptation and the study of specific adaptogenic activity standardized approaches to biomedical (preclinical) research of new biologically active substances, ensuring their comparability. The analysis of modern views on adaptation processes, as an increase in nonspecific resistance to adaptive effects, and the properties of known adaptogens is carried out. It has been shown that adaptogenic action can be realized through the involvement of several regulatory pathways, such as changes in the activity of neurons and endocrine response in response to adverse effects, interaction with cell receptors and modulation of their sensitivity to endogenous regulators, changes in the composition of cell membranes, structure of the cytoskeleton, activities of enzyme complexes, epigenomic regulation, antioxidant and antiradical activity. A grouping of methods for the experimental study of adaptogens is proposed on the basis of their compliance with the definition of this pharmacological class and the requirements of evidence-based medicine. The groups of methods aimed at increasing the rate and stability of the formation of a state of increased resistance to adverse influences, reparative-restorative processes, nonspecific resistance, psychoactivating and neuroplastic effects, antimutagenic and anticarcinogenic effects were identified. Specific schemes of adaptive influences and criteria for assessing adaptogenic activity are proposed on the basis of comparing the results obtained with the effects of "reference" adaptogens. The technology of the integrated assessment of the results of the methods, which are different in their informational significance, has been substantiated.

ECDYSTEROIDS IN NATURE AND THEIR PROPERTIES

2019 ◽  
Vol 5 (3) ◽  
pp. 26-28
Author(s):  
Э. Наумова ◽  
E. Naumova ◽  
Б. Валентинов ◽  
B. Valentinov
Keyword(s):  
Raw Materials ◽  
Folk Medicine ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Natural Sources ◽  
Natural Origin ◽  
Adaptogenic Activity ◽  
Active Substances

Ecdysteroids are biologically active substances of natural origin. Their adaptogenic activity, hormone-like and bioregulatory effects used in traditional and folk medicine are known. Sources of raw materials are diverse. Applications depend on the methods of obtaining ecdysteroids and their natural sources.

scholarly journals RESEARCH OF ANTIOXIDANT PROPERTIES OF EXTRACTS OF THE PLANTS AND THE CALLUS BIOMASS

2017 ◽  
Vol 10 (7) ◽  
pp. 182 ◽  
Author(s):  
Roksolana Konechna ◽  
Оksana Khropot ◽  
Romana Petrina ◽  
Maria Kurka ◽  
Zoriana Gubriy ◽  
...  
Keyword(s):  
Natural Habitat ◽  
Antioxidant Properties ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Plant Materials ◽  
Biomass Extract ◽  
Set Up ◽  
Definition Of ◽  
Active Substances

Objective: This study was undertaken to research of antioxidant properties of extracts of the plants and the callus biomass.Methods: The implementation of the method of cultivating the cells, tissues, and organisms in vitro for the reception of biological material of Carlina аcaulis L. (Asteraceae) is a timely issue for the medical and pharmaceutic industry, as the domestication in vitro creates the opportunity for the year-round production of the plant material as the source of biologically active substances. The seeds and plant materials (roots) of C. acaulis L. collected from natural habitat - meadows mountains Klyva Tarnychkovain Ukraine in the Carpathians. The influence of phytohormones on growth processes of plant cells is researched; the optimal conditions for the cultivation of C. acaulis L. are defined and chosen. Biomass extract is obtained and researched for the presence of biologically active substances and conducted definition of oxygen radical absorbance capacity (ORAC) of extracts of medical herbs and callus biomass of C. acaulis L.Results: C. аcaulis L. was cultivated in vitro. There was set up a scheme of sterilization of seeds with the biggest outcome of aseptic explants. There took place the investigation of the qualitative content of the extracts of callus biomass of C. acaulis L. and the detection of flavonoids and tannins. Conducted definition of ORAC of extracts of medical herbs and callus biomass of C. acaulis L. Conclusion: The obtained data showed that the investigated extracts of callus biomass and biomass of the medical herb C. acaulis L. having antioxidant activity, which makes it possible to continue research in this direction.

Microscopic fungi of lithobiont communities of Argentine Islands Region: Data from the 22nd Ukrainian Antarctic Expedition

2020 ◽  
Vol 62 (1-2) ◽  
pp. 49-68
Author(s):  
T. O. Kondratiuk ◽  
T. V. Beregova ◽  
I. Yu. Parnikoza ◽  
S. Y. Kondratyuk ◽  
A. Thell
Keyword(s):  
Filamentous Fungi ◽  
Mucor Circinelloides ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Microscopic Fungi ◽  
Rhodotorula Rubra ◽  
Yeast Fungi ◽  
Antarctic Expedition ◽  
Geomyces Pannorum ◽  
Active Substances

The identification of the diversity of microscopic fungi of lithobiont communities of the Argentine Islands in specimens collected during the 22nd Ukrainian Antarctic Expedition was the purpose of this work. Samples of rock, soil, mosses and lichens of rock micro-habitats of “Crustose lichen sub-formation and fruticose lichen and moss cushion sub-formation” were used in the work. These samples were used for extracting and cultivation of filamentous fungi on dense nutrient media. Determination of physiological and biochemical characteristics and identification of yeast-like fungi were performed using a microbiological analyser ‘Vitek-2’ (‘Bio Merieux’, France). Cultivation of microorganisms was carried out at temperatures from +2 to +37 °C. In results cultures of microscopic fungi of Zygomycota (Mucor circinelloides), Ascomycota (species of the genera cf. Tlielebolus, Talaromyces), representatives of the Anamorphic fungi group (Geomyces pannorum, species of the genera Alternaria, Acremonium, Aspergillus, Penicillium, and Cladosporium) were isolated from Antarctic samples. Microscopic fungi Penicillium spp. were dominated after the frequency in the studied samples (54.5%). Rhodotorula rubra and Candida sp. among isolated yeast fungi, and dark pigmented fungi represented by Aureobasidium pulhdans and Exophiala spp. were identified. The biological properties of a number of isolated fungi (the potential ability to synthesise important biologically active substances: melanins, carotenoids, lipids) are characterised. Mycobiota of rock communities of Argentine Islands is rich on filamentous and yeast fungi similarly to other regions of Antarctica. A number of fungi investigated are potentially able to synthesise biologically active substances. The dark pigmented species of the genera Cladosporium, Exophiala, Aureobasidium pulhdans, capable of melanin synthesis; ‘red’ yeast Rhodotorula rubra (carotenoid producers and resistant to toxic metals); Mucor circinelloides and Geomyces pannorum, lipid producers, are among these fungi. Yeast-like fungi assimilated a wide range of carbohydrates, which will allow them to be further used for cultivation in laboratory and process conditions. The collection of technologically promising strains of microorganisms, part of the Culture Collection of Fungi at Taras Shevchenko National University of Kyiv (Ukraine), is updated with isolated species (strains) of filamentous fungi and yeast – potential producers of biologically active substances, obtained within this study.

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

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