scholarly journals The effectiveness of anti-helicobacter therapy in the treatment of chronic gastroduodenal pathology in children with different levels of compliance

2018 ◽  
Vol 9 (4) ◽  
pp. 81-86
Author(s):  
Andrew V. Nalyotov ◽  
Sergey V. Nalyotov ◽  
Anna S. Barinova ◽  
Oleg G. Gorshkov
Keyword(s):  
Interpersonal Relationships ◽  
Sick Child ◽  
Disease Treatment ◽  
Strict Adherence ◽  
Ulcer Disease ◽  
Compliance Training ◽  
Parental Compliance ◽  
H Pylori ◽  
High Level ◽  
Different Levels

At the present time, the therapy of most diseases requires special attention not only from the treating physician, but also from the patient. In turn, in the treatment of children, the monitoring of compliance with the treatment is carried out not by the patient, but by his parents who control the regimen of taking medications. The aim of the study was to determine the efficiency of traditional anti-H. pylori regimen in the treatment of chronic gastroduodenal pathology in children with various level of parental compliance. 80 children of school age suffering from peptic ulcer disease duodenal ulcer associated with H. pylori from families with different levels of parental compliance were examined. The traditional anti-H. pylori therapy scheme containing omeprazole, clarithromycin lasting 14 days was prescribed for all children with chronic gastroduodenal pathology. It is established that strict adherence to the regimen and duration of administration of prescribed drugs allows achieving a high level of eradication of H. pylori even with the use of the traditional anti-Helicobacter pylori. Conducting a “compliance training” before starting therapy is an important factor that increases the level of parental compliance in patients with inflammatory-destructive diseases of the stomach and duodenum. Establishment of interpersonal relationships in the “doctor-patient-parent” system, working with parents, aimed at explaining the essence of the disease, the consequences of the disease, treatment tactics are an important stage in the therapy of a sick child.

scholarly journals Influence of parental compliance on the effectiveness of treatment of chronic gastroduodenal pathology in children

2019 ◽  
Vol 5 (4) ◽  
pp. 69-74
Author(s):  
Anna S. Barinova ◽  
Andrey V. Naletov ◽  
Sergey V. Naletov ◽  
Dmitry I. Masyuta ◽  
Evgeniy A. Perederiy
Keyword(s):  
Eradication Therapy ◽  
Outpatient Setting ◽  
Endoscopic Examination ◽  
Strict Adherence ◽  
Compliance Training ◽  
Parental Compliance ◽  
Second Stage ◽  
High Level ◽  
Families With Children ◽  
Dosage Frequency

Introduction: The article focuses on the studies which point to particular difficulties in achieving compliance in pediatrics. A dangerous trend to escalate the number and doses of antibiotics in anti- Helicobacter pylori (HP) schemes, the dosage frequency and course duration of eradication therapy considerably complicates a patient’s compliance to the treatment and contributes to a further growth of HP antibiotic resistance. In the treatment of children, the control of the outpatient therapy largely depends on the patient’s parents. Materials and methods: At the first stage of the study, 103 children with chronic gastroduodenal pathology associated with HP were examined. Diagnosis of the disease was based on the study of complaints, the anamnesis data, and the results of the endoscopic examination. All the patients underwent a course of anti-HP therapy in the outpatient setting. A degree of parental compliance to their child’s therapy was determined in by a questionnaire, which had been developed by us, the families of the children suffering from chronic gastroduodenal pathology. At the second stage, 80 children suffering from peptic ulcer associated with HP were examined. HP was eradicated in the outpatients of both groups, using an anti-HP regimen: omeprazole, clarithromycin, and amoxicillin administered for 14 days. The influence of the measures to improve parental compliance carried out in tandem “doctor – pharmacist” in the families with children suffering from chronic gastroduodenal pathology was studied. Results and discussion: A decrease in parental compliance was observed in more than 2/3 of the families with children suffering from chronic gastroduodenal pathology, associated with HP infection. A higher level of parental compliance was established in the families of children after the ”compliance training”. In the patients of this group, eradication of HP was achieved in 87.5% cases by using a traditional scheme: omeprazole, clarithromycin, and amoxicillin administered for 14 days. Conclusion: It can be concluded that the level of parental compliance to an anti-HP therapy for their children is insufficient. In turn, conducting a “compliance training” in the tandem of ”doctor – pharmacist” before starting the therapy is an important factor in increasing the level of parental compliance, which is reflected in increasing the effectiveness of the treatment. Strict adherence to the regimen and duration of administration of the prescribed drugs in children with ulcer allows achieving a high level of HP eradication – 95.2 %, even when using the traditional anti-HP regimen. The eradication was achieved in 56.5 % of the children with partial parental compliance, and only in 6.7 % of the children with non-compliant parents.

scholarly journals Parental compliance and influences factors in treatment of children with irritable bowel syndrome

2018 ◽  
Vol 9 (2) ◽  
pp. 67-70 ◽  
Author(s):  
Andrew V. Nalyotov ◽  
Yulia S. Vunichenko ◽  
Dmitry I. Masyuta
Keyword(s):  
Irritable Bowel Syndrome ◽  
Interpersonal Relationships ◽  
Sick Child ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Disease Treatment ◽  
Rome Criteria ◽  
Factors Affecting ◽  
Parental Compliance ◽  
Irritable Bowel

Summary. The irritable bowel syndrome is one of the most common of functional gastrointestinal tract disorders in the population. The Rome criteria IV are basic recommendations for the diagnosis and treatment of functional gastrointestinal disorders in patients of different ages. At the present time, the therapy of most diseases requires special attention not only from the treating physician, but also from the patient. In turn, in the treatment of children, the monitoring of compliance with the treatment is carried out not by the patient, but by his parents who control the regimen of taking medications. The aim of the study was to determine the level of parental compliance and factors affecting it in the treatment of children with irritable bowel syndrome. It was established that the level of parental compliance to the treatment of irritable bowel syndrome for their children is low, which may lead to a decrease in the effectiveness of the treatment. It was found that only in less than 1/3 of the patients the parents are fully compliant with respect to the therapy received by their child. The main causes that influence the adherence of parents to the treatment of their child with irritable bowel syndrome are revealed. Establishment of interpersonal relationships in the “doctor-patient-parent” system, working with parents, aimed at explaining the essence of the disease (in some cases, the mechanisms of its formation), the consequences of the disease, treatment tactics are an important stage in the therapy of a sick child.

scholarly journals Virulence Factors of Helicobacter pylori: A Review

2014 ◽  
Vol 7 ◽  
pp. CGast.S13760 ◽  
Author(s):  
Bruna M. Roesler ◽  
Elizabeth M.A. Rabelo-Gonçalves ◽  
José M.R. Zeitune
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Outcome ◽  
Virulence Factors ◽  
Ulcer Disease ◽  
Clinical Disorders ◽  
H Pylori ◽  
High Level ◽  
Upper Gastrointestinal ◽  
Host Characteristics

Helicobacter pylori is a spiral-shaped Gram-negative bacterium that colonizes the human stomach and can establish a long-term infection of the gastric mucosa, a condition that affects the relative risk of developing various clinical disorders of the upper gastrointestinal tract, such as chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. H. pylori presents a high-level of genetic diversity, which can be an important factor in its adaptation to the host stomach and also for the clinical outcome of infection. There are important H. pylori virulence factors that, along with host characteristics and the external environment, have been associated with the different occurrences of diseases. This review is aimed to analyzing and summarizing the main of them and possible associations with the clinical outcome.

scholarly journals H. pyloriVirulence Factors: Influence on Immune System and Pathology

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Behnam Kalali ◽  
Raquel Mejías-Luque ◽  
Anahita Javaheri ◽  
Markus Gerhard
Keyword(s):  
Virulence Factors ◽  
Hygiene Hypothesis ◽  
The Other ◽  
Bacterial Physiology ◽  
Ulcer Disease ◽  
Bacterial Agent ◽  
Microbiological Characteristics ◽  
Socioeconomic Issues ◽  
H Pylori ◽  
High Level

Helicobacter pyloriis the most widespread chronic bacterial agent in humans and is well recognized for its association with ulcer disease and gastric cancer, with both representing major global health and socioeconomic issues. Given the high level of adaptation and the coevolution of this bacterium with its human host, a thorough and multidirectional view of the specific microbiological characteristics of this infection as well as the host physiology is needed in order to develop novel means of prevention of therapy. This review aims to pinpoint some of these potentially important angles, which have to be considered mutually when studyingH. pylori’s pathogenicity. The host’s biological changes due to the virulence factors are a valuable pillar ofH. pyloriresearch as are the mechanisms by which bacteria provoke these changes. In this context, necessary adhesion molecules and significant virulence factors ofH. pyloriare discussed. Moreover, metabolism of the bacteria, one of the most important aspects for a better understanding of bacterial physiology and consequently possible therapeutic and prophylactic strategies, is addressed. On the other hand, we discuss the recent experimental proofs of the “hygiene hypothesis” in correlation withHelicobacter’s infection, which adds another aspect of complexity to this infection.

scholarly journals FEATURES OF INTERPERSONAL INTERACTION OF PSYCHOLOGISTS WITH DIFFERENT LEVELS OF SOCIAL INTELLIGENCE

2020 ◽  
Vol 2020 (1) ◽  
pp. 41-48
Author(s):  
Svitlana Sytnik ◽  
Oleksiy Chebykin
Keyword(s):  
Interpersonal Relationships ◽  
Social Intelligence ◽  
Emotional Stability ◽  
Interpersonal Interaction ◽  
Professional Activity ◽  
Emotional Instability ◽  
High Level ◽  
Relationship Of ◽  
The Relationship ◽  
Different Levels

An important aspect of the professional activity of psychologists is the interpersonal interaction, the effectiveness of which depends on many factors. One of them may be a social intelligence. The study of the relationship between social intelligence and the characteristics of interpersonal interaction can point at the possibility of improving the professional skills of psychologists, through the activation of their social intelligence, which is related to the level of interpersonal interaction. This interaction is an important component of the professionalism of the psychologist. The purpose of the article was to study the relationship of particularities of interpersonal interaction of psychologists with different levels of social intelligence and their individual psychological characteristics. The theoretical and experimental methods were used in the study. The latter include the following methods: "Assessment of interpersonal interaction" (Sytnik S. V.); "Study of Social Intelligence" (J. Guilford); "16-PF Personal Questionnaire" (R. Kettell). The relationship of indicators of interpersonal interaction with social intelligence and character traits of individual were presented in the article. The interpersonal interaction includes such indicators as primary contact, interpersonal communication and interpersonal relationships. A sufficient level of development of social intelligence is associated with effective interpersonal interaction. The direct connections of indicators of interpersonal interaction with such personality traits as sociability, emotional stability, courage, trust, practicality, calmness are determined. The feedback was also identified with traits such as hostility, irritability, low tolerance for frustration, shyness, social passivity, cruelty, anxiety, and selfdoubt. It is investigated that a high level of social intelligence is a condition for the development of all stages of interpersonal interaction. The subjects who are capable of interpersonal interaction at a high level have such traits as sociability, trust, balance, courage, emotional stability. Individuals with a low level of interpersonal interaction often show: emotional instability, social passivity, isolation, hostility, irritability, suspicion. The obtained results are important for the psychological training of psychologists as representatives of socionomic professions, in order to realize themselves in professional activities.

Vacuoles Induced in Mammalian Cells by Helicobacter Cytotoxin are Acidic Organelles

1990 ◽  
Vol 48 (3) ◽  
pp. 168-169
Author(s):  
M. H. Chestnut ◽  
C. E. Catrenich
Keyword(s):  
Acridine Orange ◽  
Mammalian Cells ◽  
Laser Scanning ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Ulcer Disease ◽  
Gastroduodenal Disease ◽  
H Pylori

Helicobacter pylori is a non-invasive, Gram-negative spiral bacterium first identified in 1983, and subsequently implicated in the pathogenesis of gastroduodenal disease including gastritis and peptic ulcer disease. Cytotoxic activity, manifested by intracytoplasmic vacuolation of mammalian cells in vitro, was identified in 55% of H. pylori strains examined. The vacuoles increase in number and size during extended incubation, resulting in vacuolar and cellular degeneration after 24 h to 48 h. Vacuolation of gastric epithelial cells is also observed in vivo during infection by H. pylori. A high molecular weight, heat labile protein is believed to be responsible for vacuolation and to significantly contribute to the development of gastroduodenal disease in humans. The mechanism by which the cytotoxin exerts its effect is unknown, as is the intracellular origin of the vacuolar membrane and contents. Acridine orange is a membrane-permeant weak base that initially accumulates in low-pH compartments. We have used acridine orange accumulation in conjunction with confocal laser scanning microscopy of toxin-treated cells to begin probing the nature and origin of these vacuoles.

ANTICYTOKINE ACTIVITY OF THE PROTOZOA BLASTOCYSTIS SPP

2020 ◽  
pp. 44-48
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Ulcer Disease ◽  
Cytokine Balance ◽  
High Prevalence ◽  
Blastocystis Spp ◽  
High Level ◽  
Eukaryotic Organisms ◽  
High Degree

In addition to the classical pathogens, which are well understood and well identified, new pathogens with the potential to spread epidemiologically are being identified. Some of these little-known organisms are the simplest Blastocystis spp. blastocystostosis. The clinical significance of Blastocystis spp. and its pathogenicity are still under discussion. This parasite belongs to a group of single-celled eukaryotic organisms living in the colon of the human intestine. Blastocystis spp. is known to be found both in people with reduced immune status and in individuals without any clinical manifestation. It has been established that a sufficiently high degree of invasiveness is observed in persons with gastrointestinal tract diseases, dermatosis, allergic reactions, in patients with carriers of the human immunodeficiency virus, etc. Possessing persistence factors, protozoa blastocysts contribute to the inactivation of host defensive mechanisms, providing a stable anthogonistic effect. In recent years, many works have been devoted to the characteristics of the persistent properties of Blastocystis spr., however, individual properties of blastocysts, in particular, anticytokine activity (ACA), have not yet been studied. In this regard, the work studied the anticytokine activity of microorganisms isolated from healthy subjects and patients with gastrointestinal tract diseases. A high prevalence of the studied characteristic in the subjects was shown. The expression of anticytokine activity in the obtained isolates of blastocysts was the highest in the group of persons with gastric ulcer disease, which decreased in the order of duodenal ulcer, chronic cholecystitis, chronic gastritis, etc. The data obtained in this work on the high level of ACA expression in blastocyst isolates obtained from individuals with gastrointestinal diseases as compared with the control group enables to conclude that their exometabolites may influence the local cytokine balance [1], which supports the inflammatory process.

Lifestyle and Peptic Ulcer Disease

2018 ◽  
Vol 24 (18) ◽  
pp. 2034-2040 ◽  
Author(s):  
Berrak C. Yegen
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Alcohol Intake ◽  
Night Sleep ◽  
Unhealthy Lifestyle ◽  
Coping With Stress ◽  
Analgesic Drugs ◽  
Ulcer Disease ◽  
Balanced Diet ◽  
H Pylori

The risk of developing Peptic Ulcer Disease (PUD) was shown to be associated with genetic inheritance, lifestyle and social status of the patients. Unhealthy lifestyle habits and failure in coping with stress have been closely associated with the occurrence of PUD. In contrary, limiting the use of analgesic drugs and glucocorticoids, controlling environmental and socioeconomic factors that predispose to H. Pylori infection, having a balanced diet, exercising regularly, coping successfully with stress, avoiding smoking, limiting alcohol intake and getting sufficient night sleep are essential in prevention and healing of PUD.

scholarly journals The number of household members as a risk factor for peptic ulcer disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Hong Yim ◽  
Keun Ho Kim ◽  
Bum Ju Lee
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Living Alone ◽  
Cross Sectional ◽  
Ulcer Disease ◽  
Logistic Regression Models ◽  
Household Members ◽  
H Pylori

AbstractPeptic ulcer disease (PUD) is caused by many sociodemographic and economic risk factors other than H. pylori infection. However, no studies reported an association between PUD and the number of household members. We showed the number of family members affected by PUD based on sex in a Korean population. This cross-sectional study used 1998–2009 data from the Korea National Health and Nutrition Examination Survey of the Korea Centers for Disease Control and Prevention. Multiple binary logistic regression models adjusted for confounders were constructed to analyze the association of PUD with the number of household members. The number of household members was associated with PUD, age, body mass index (BMI), waist circumference, systolic blood pressure, hemoglobin, glucose, location (urban/rural), income, education level, stress, current drinking, and smoking in both sexes. Men with other household members had a higher PUD risk compared to men or women living alone (reference), and the opposite was observed for women. Men with 4 household members had a higher PUD risk than men living alone in the model adjusted for age, BMI, income, location, education, and stress (OR = 2.04 [95% CI 1.28–3.27], p value = .003). Women with more than 6 household members had a lower PUD risk than women living alone in the adjusted model (OR = 0.50 [0.33–0.75], p value = .001). Women with more household members had a lower PUD risk. However, more men had PUD than women regardless of the number of household members.

scholarly journals Aircraft Requirements for Sustainable Regional Aviation

Aerospace ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 61
Author(s):  
Dominik Eisenhut ◽  
Nicolas Moebs ◽  
Evert Windels ◽  
Dominique Bergmann ◽  
Ingmar Geiß ◽  
...  
Keyword(s):  
Systems Engineering ◽  
System Level ◽  
Policy Initiative ◽  
The European Union ◽  
Calculation Methods ◽  
Figures Of Merit ◽  
Performance Requirements ◽  
High Level ◽  
Different Levels ◽  
The Eu

Recently, the new Green Deal policy initiative was presented by the European Union. The EU aims to achieve a sustainable future and be the first climate-neutral continent by 2050. It targets all of the continent’s industries, meaning aviation must contribute to these changes as well. By employing a systems engineering approach, this high-level task can be split into different levels to get from the vision to the relevant system or product itself. Part of this iterative process involves the aircraft requirements, which make the goals more achievable on the system level and allow validation of whether the designed systems fulfill these requirements. Within this work, the top-level aircraft requirements (TLARs) for a hybrid-electric regional aircraft for up to 50 passengers are presented. Apart from performance requirements, other requirements, like environmental ones, are also included. To check whether these requirements are fulfilled, different reference missions were defined which challenge various extremes within the requirements. Furthermore, figures of merit are established, providing a way of validating and comparing different aircraft designs. The modular structure of these aircraft designs ensures the possibility of evaluating different architectures and adapting these figures if necessary. Moreover, different criteria can be accounted for, or their calculation methods or weighting can be changed.

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