scholarly journals Vegetative regulation in the first three months of life in premature infants born with intrauterine growth retardation

2018 ◽  
Vol 9 (4) ◽  
pp. 36-43
Author(s):  
Elena A. Bliznetsova ◽  
Liudmila K. Antonova ◽  
Alexandr N. Malinin
Keyword(s):  
Body Weight ◽  
Preterm Infants ◽  
Premature Infants ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Wave Spectrum ◽  
High Frequency Component ◽  
Control Group ◽  
Intrauterine Growth ◽  
Vegetative Regulation

Goal. To study the dynamics of vegetative states in preterm infants with intrauterine growth retardation (IUGR) during the first three months of life. Materials and methods. Examined 34 preterm infants with IUGR – 1st group (GA – 33,3 ± 1,4 weeks, body weight – 1557,8 ± 63,8 g, length – 41,2 ± 1,7 cm) at the age of 5 days and 3 months of life; 51 premature infants without IUGR (GA – 33,2 ± 1,02 weeks, body weight 2062,0 ± 63,9 grams, length – 44,0 ± 1,4 cm) – 2nd group; a control group included 31 healthy full-term infants (GA – 38,8 ± 1,5 weeks, body weight – 3355,4 ± 147,6 grams, length – 52,7 ± 2,3 cm). The vegetative tester “Polispektr-8E/88” (2000 Hz, 12 bit), from the Russian firm “Neurosoft”, was used. Indicators of the cardiointervalogram (CIG) and spectrogram were determined in the baseline sample and in the orthostatic test (tilt-test). Results. Among the indicators of CIG there was a noticeable decrease of mode (Mo, s) in 2 groups of preterm infants at 5 days of life (p < 0,05) and an increase in stress-index by 3 months of age in 1 group (p < 0,05). The study revealed the predominance in the structure of the wave spectrum of the VLF-component in all groups of children to 3 months; children 1 group had a lower value of this indicator, but they also had a higher proportion of high frequency component (HF, %) (p < 0,05). Vagotonic initial vegetative tonus (IVT) was defined only in 1 group, while the frequency of sympathicotonic and hypersympathicotonic IVT decreased (p < 0,05). Asympathicotonia vegetative reactivity (AST VR) in premature infants with IUGR was increased from 38, to 72,7% to 3 months (p < 0,05). Conclusion. The study revealed the lack of influence of the Central contour vegetative regulation, more intense adaptation and high exhaustion of the functional reserve in preterm infants with IUGR to 3 months of life.

Differential Effects of Maternal Heroin and Methadone Use on Birthweight

PEDIATRICS ◽  
1976 ◽  
Vol 58 (5) ◽  
pp. 681-685
Author(s):  
Stephen R. Kandall ◽  
Susan Albin ◽  
Joyce Lowinson ◽  
Beatrice Berle ◽  
Arthur I. Eidelman ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Methadone Maintenance ◽  
First Trimester ◽  
Control Group ◽  
Fetal Growth Retardation ◽  
Intrauterine Growth ◽  
Methadone Dosage ◽  
History Of

An analysis of birthweights of 337 neonates in relation to history of maternal narcotic usage was undertaken Mean birthweight of infants born to mothers abusing heroin during the pregnancy was 2,490 gm, an effect primarily of intrauterine growth retardation. Low mean birthweight (2,615 gm) was also seen in infants born to mothers who had abused heroin only prior to this pregnancy, and mothers who had used both heroin and methadone during the pregnancy (2,535 gm). Infants born to mothers on methadone maintenance during the pregnancy had significantly higher mean birthweights (2,961 gm), but lower than the control group (3,176 gm). A highly significant relationship was observed between maternal methadone dosage in the first trimester and birthweight, i.e., the higher the dosage, the larger the infant. Heroin causes fetal growth retardation, an effect which may persist beyond the period of addiction. Methadone may promote fetal growth in a dose-related fashion after maternal use of heroin.

scholarly journals Transitory hypothermia as early prognostic factor in term newborns with intrauterine growth retardation

2010 ◽  
Vol 138 (9-10) ◽  
pp. 604-608 ◽  
Author(s):  
Tanja Lazic-Mitrovic ◽  
Milan Djukic ◽  
Nedjo Cutura ◽  
Spaso Andjelic ◽  
Aleksandar Curkovic ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Body Mass ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Perinatal Asphyxia ◽  
Control Group ◽  
Intrauterine Growth ◽  
Pathological Conditions ◽  
Term Newborns ◽  
The One

Introduction. According to numerous researches, transitory hypothermia is a part of the neonatological energetic triangle and represents a significant prognostic factor within morbidity and mortality in newborns with intrauterine growth retardation (IUGR), that are, due to their characteristics, more inclined to transitory hypothermia. Objective. The aim of the study was an analysis of frequency of transitory hypothermia in term newborns with IUGR, as well as an analysis of frequency of the most frequent pathological conditions typical of IUGR newborns depending on the presence of transitory hypothermia after birth (hypoglycaemia, perinatal asphyxia, hyperbilirubinaemia and hypocalcaemia). Methods. The study included 143 term newborns with IUGR treated at the Neonatology Ward of the Gynaecology- Obstetrics Clinic ?Narodni front?, Belgrade. The newborns were divided into two groups: the one with registered transitory hypothermia - the observed group, and the one without transitory hypothermia - the control group. The data analysis included the analysis of the frequency of transitory hypothermia depending on gestation and body mass, as well as the analysis of pathological conditions (perinatal asphyxia, hypoglycaemia, hypocalcaemia, hyperbilirubinaemia) depending on the presence of hypothermia.The analysis was done by statistical tests of analytic and descriptive statistics. Results. In morbidity structure dominate hypothermia (65.03%), hypoglycaemia (43.36%), perinatal asphyxia (37.76%), hyperbilirubinaemia (30.77%), hypocalcaemia (25.17%). There were 93 newborns in the observed group, and 50 in the control one. Mean value of the measured body temperature was 35.9?C. 20 newborns (32.26%) had moderate hypothermia, and 73 newborns (67.74%) had mild hypothermia. In the observed group, average gestation was 39.0 weeks, and 39.6 (p<0.01) in the control group. Average body mass at birth in the whole group was 2339 g: 2214 g in the observed and 2571 g in the control group. The frequency of hypoglycaemia in the observed group was 53.8%, and 24% in the control group (p<0.01). In the observed group, the frequency of pH<7.25 was 38.71%, and 14% in the control group (p<0.05). The frequency of hyperbilirubinaemia was 38.71% in the observed group, and 16% in the control group (p<0.01). The frequency of hypocalcaemia was 32.26% in the observed, and 12% in the control group (p<0.01). Conclusion. Transitory hypothermia in the first ten hours of life represents a significant risk factor for deepening hypoglycaemia, asphyxia, hyperbilirubinaemia and hypocalcaemia in term newborns with IUGR.

scholarly journals Morphofunctional features of platelets in premature newborns with very low and extremely low body weight

2021 ◽  
Vol 12 (2) ◽  
pp. 35-41
Author(s):  
Anastasia V. Budalova ◽  
Natalia V. Kharlamova ◽  
Galina N. Kuzmenko
Keyword(s):  
Body Weight ◽  
Platelet Count ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Gestational Age ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Distress Syndrome ◽  
Premature Newborns ◽  
Intrauterine Growth

Background. Currently, the development of medicine in the field of perinatology is aimed at improving the quality of medical care for newborns, especially those born prematurely. Premature newborns are most likely to develop hemorrhagic disorders, which often aggravates their condition and determines high morbidity and mortality. On modern hematological analyzers, it has become possible to evaluate a larger number of blood parameters, including platelet parameters, however, there are a small number of studies devoted to the study of platelet parameters in premature newborns. The aim was to study the morphofunctional features of platelets in premature newborns with very low and extremely low body weight. Materials and methods. The study included 78 newborns born at 2534 weeks of gestation, with a body weight of less than 1500 grams. On the 3rd5th day of life, a clinical blood test was performed on the Advia 2120i hematological analyzer (Siemens), with the determination of platelet parameters: PLT, 103 cells/l, PCT, %, PDW, %, Large Plt, 103 cells/l, MPC, g/dl, MRM, pg. Results. In newborns with ELBW, a decrease in the number and granularity of platelets in the blood, an increase in the average dry mass of platelets was found. Newborns with intrauterine growth retardation have a reduced platelet count and reduced thrombocrit. In premature newborns with a gestational age of 2527 weeks, blood circulation of platelets with a reduced volume was established, and in newborns who were born at a gestational age of 3234 weeks with increased granularity. In the absence of antenatal prevention of respiratory distress syndrome in newborns, there is a decrease in thrombocrit, the number of platelets, including large forms in the blood. In premature newborns born in a state of severe asphyxia, a decrease in platelet granularity was noted. The use of high concentrations of O2 in the oxygen-air mixture during respiratory therapy leads to a decrease in the number of platelets in the blood. Conclusions. Factors determining the morphofunctional state of platelets in premature newborns were established: the presence of a full course of antenatal prevention of respiratory distress syndrome of newborns, gestational age, the severity of asphyxia at birth, as well as the concentration of O2 in the oxygen-air mixture used in respiratory therapy. Newborns with ELBW have a reduced platelet count, low-granulated platelets, and an increased average dry platelet mass. Newborns with intrauterine growth retardation have a reduced number of platelets and thrombocrit in the blood. The revealed morphofunctional features of platelets allow us to clarify the nature of changes in the platelet link of hemostasis in premature newborns for the timely prevention of complications during the underlying disease.

HUMAN FETAL GROWTH RETARDATION: I. CLINICAL FEATURES OF SAMPLE WITH INTRAUTERINE GROWTH RETARDATION

PEDIATRICS ◽  
1972 ◽  
Vol 50 (4) ◽  
pp. 547-558
Author(s):  
J. Urrusti ◽  
P. Yoshida ◽  
L. Velasco ◽  
S. Frenk ◽  
A. Rosado ◽  
...  
Keyword(s):  
Birth Weight ◽  
Premature Infants ◽  
Fetal Growth ◽  
Gestational Age ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Fetal Growth Retardation ◽  
Neonatal Deaths ◽  
Intrauterine Growth ◽  
Normal Term

Intrauterine growth was assessed in a series of 128 cases. Thirty-six infants were small for gestational age, and showed the usual signs of intrauterine growth retardation (IUM). The head circumference of these infants was small, with reference to normal term babies (FT) and comparable to premature infants, appropriately sized for a gestational age (ACA) five weeks less than that of the IUM's. There were 12 neonatal deaths, three among IUM infants within 24 hours and nine in the low birth weight AGA group within 72 hours. The mothers of these three groups of infants were similar with respect to age, weight, height, nutritional patterns, and prior pregnancy histories.

scholarly journals The nature of relationship between some health parameters in infants born with hypoplastic type mild intrauterine growth retardation

2020 ◽  
Vol 11 (2) ◽  
pp. 15-24
Author(s):  
Dmitry O. Ivanov ◽  
Vitaly V. Derevtsov
Keyword(s):  
Body Weight ◽  
Body Length ◽  
Growth Retardation ◽  
Sympathetic Activity ◽  
Intrauterine Growth Retardation ◽  
Atrioventricular Conduction ◽  
Stress Index ◽  
Healthy Children ◽  
Intraventricular Conduction ◽  
Intrauterine Growth

Objective. Assessing the relationship between health indicators in infants born with intrauterine growth retardation (JGR) of hypoplastic type of mild severity among themselves, compared with infants born without IGR, and with practically healthy infants from practically healthy mothers. Materials and methods. Under the supervision were 109 infants. From mothers with a burdened somatic and obstetric-gynecological history, 84 children were born: 15 (gr. 1) with mild of hypo-plastic type IGR, 69 (gr. 2) without IGR. The control group (gr. 3) consisted of 25 healthy children born to healthy mothers. All observed babies were born full-term. They were examined in dynamics at the age of 1 (n = 104), 3 (n = 98), 6 (n = 92), 12 (n = 94) months. Outcome recording methods were a comprehensive case history analysis, physical examination, assessment of electrocar-diography and cardiointervalography. Distribution-free statistical analysis methods. Results. A correlation was found at 23 days between weight and body length (r = 0.63), body weight and stress index (r = 0.56), sympathetic activity and stress index (r = 0.84), intraatrial and atrioventricular conductivity (r = 0.64); at 1 month between sympathetic activity and stress index (r = 0.62); at 3 months between weight and body length (r = 0.79), sympathetic activity and stress index (r = 0.87), sympathetic activity and intraventricular conduction (r = 0.67), intraatrial and atrioventricular conduction (r = 0.71); at 6 months between weight and body length (r = 0.81), body weight and intraatrial conduction (r = 0.65), body weight and electric systole (r = 0.58), sympathetic activity and stress index (r = 0.92); at 12 months between body length and intraatrial (r = 0.74), body length and atrioventricular conduction (r = 0.76), sympathetic activity and stress index (r = 0.94), sympathetic activity and electrical systole (r = 0.71), stress index and intraventricular conduction (r = 0.68), stress index and electric systole (r = 0.69), intraatrial and stress index (r = 0.9), atrioventricular conduction and electric systole (r = 0.63). Conclusions. The revealed correlation communications between of some studied parameters allow doctors to allocate groups of dispensary observation, to diagnose changes at early stages of the pathological process, conduct correctional actions with assessment of their efficiency.

Epidemiology of Inguinal Hernia in Preterm Neonates

PEDIATRICS ◽  
1986 ◽  
Vol 77 (2) ◽  
pp. 246-247 ◽  
Author(s):  
KEITH J. PEEVY ◽  
FELICITY A. SPEED ◽  
CHARLES J. HOFF
Keyword(s):  
Inguinal Hernia ◽  
Birth Weight ◽  
Preterm Infants ◽  
Gestational Age ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Preterm Neonates ◽  
Intrauterine Growth ◽  
Inguinal Hernias

We have studied the epidemiology of inguinal hernias in preterm infants. Inguinal hernias occur with increased frequency in infants ≤32 weeks' gestational age or ≤1,250 g birth weight. Among infants ≤32 weeks' gestational age, intrauterine growth retardation significantly increases the risk for development of inguinal hernias, especially in male infants. Our data demonstrate a previously unrecognized association between neonatal inguinal hernia and intrauterine growth retardation.

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