scholarly journals Comparative estimation of laser coagulation efficiency in macular and microphotocoagulation of high density in diabetic maculopathy treatment

2016 ◽  
Vol 9 (4) ◽  
pp. 43-45
Author(s):  
Tat’yana V Kotsur ◽  
Aleksandr S Izmaylov
Keyword(s):  
Retinal Pigment Epithelium ◽  
Side Effects ◽  
Macular Edema ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
High Density ◽  
Laser Coagulation ◽  
Retinal Sensitivity ◽  
Diabetic Maculopathy ◽  
Laser Applications

Subthreshold microphotocoagulation (MicroPulase) leads to development of barely visible or invisible retinal burns and has been shown to be effective in macular edema treatment without any side effects inherent to the ETDRS method (atrophy of retinal pigment epithelium and choroid, decrease of retinal sensitivity). Microphotocoagulation efficacy may be increased by high density laser applications, however in modern literature rare publications draw attention to this matter.

scholarly journals COMPARATIVE ESTIMATION OF LASER COAGULATION EFFICIENCY IN MACULAR AND MICROPHOTOCOAGULATION OF HIGH DENSITYIN DIABETIC MACULOPATHY TREATMENT

2015 ◽  
Vol 7 (1) ◽  
pp. 74-77
Author(s):  
A S Izmaylov ◽  
T V Kotsur
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Laser Photocoagulation ◽  
Retinal Pigment ◽  
Laser Coagulation ◽  
Retinal Sensitivity ◽  
Diabetic Maculopathy ◽  
Laser Applications ◽  
Clinically Significant ◽  
Modern Standard

The modern standard of treatment of clinically significant diabetic macular edema is macular laser photocoagulation was suggested in the reports of the Early Treatment of Diabetic Retinopathy Study (ETDRS, 1985-1990). Subthreshold microphotocoagulation (MicroPulase) leads to developing barely visible or invisible retinal burns and also has been shown to be effective in treating macular edema with no side effects comparing with ETDRS methodic (retinal pigment and choroidal atrophy, decreasing of retinal sensitivity). Effectiveness of microphotocoagulation may arise in high density laser applications, however in modern literature exists rare publications concerning this question.

scholarly journals The use of diod laser in microphotocoagulation and high density photocoagulation regimens in the treatment of diabetic macular edema

2016 ◽  
Vol 9 (2) ◽  
pp. 27-29
Author(s):  
Aleksandr S Izmaylov ◽  
Tat’yana V Kotsur
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Laser Photocoagulation ◽  
Retinal Pigment ◽  
High Density ◽  
Retinal Sensitivity ◽  
Laser Applications ◽  
Clinically Significant ◽  
Modern Standard

The modern standard of treatment of clinically significant diabetic macular edema is macular laser photocoagulation was suggested in the reports of the Early Treatment of Diabetic Retinopathy Study (ETDRS, 1985-1990). Subthreshold microphotocoagulation (MicroPulase) leads to developing barely visible or invisible retinal burns and also has been shown to be effective in treating macular edema with no side effects comparing with ETDRS methodic (retinal pigment and choroidal atrophy, decreasing of retinal sensitivity). Effectiveness of microphotocoagulation may arise in high density laser applications, however in modern literature exists rare publications concerning this question.

scholarly journals Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration

2017 ◽  
Vol 37 (24) ◽  
Author(s):  
Aswin Pyakurel ◽  
Delphine Balmer ◽  
Marc K. Saba-El-Leil ◽  
Caroline Kizilyaprak ◽  
Jean Daraspe ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Side Effects ◽  
Retinal Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Rpe Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Ocular Side ◽  
Extracellular Signal

ABSTRACT Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of age-related macular degeneration (ARMD) patients and therefore could be an attractive therapeutic target. Notably, ERK1/2 pathway inhibitors are used in cancer therapy, with severe and noncharacterized ocular side effects. To decipher the role of ERK1/2 in RPE cells, we conditionally disrupted the Erk1 and Erk2 genes in mouse RPE. The loss of ERK1/2 activity resulted in a significant decrease in the level of RPE65 expression, a decrease in ocular retinoid levels concomitant with low visual function, and a rapid disorganization of RPE cells, ultimately leading to retinal degeneration. Our results identify the ERK1/2 pathway as a direct regulator of the visual cycle and a critical component of the viability of RPE and photoreceptor cells. Moreover, our results caution about the need for a very fine adjustment of kinase inhibition in cancer or ARMD treatment in order to avoid ocular side effects.

Simple Hamartoma of the Retinal Pigment Epithelium with Macular Edema

2015 ◽  
Vol 92 ◽  
pp. S48-S50 ◽  
Author(s):  
Austin Bach ◽  
Aaron S. Gold ◽  
Victor M. Villegas ◽  
Andrea C. Wildner ◽  
Azeema Latiff ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Macular Edema ◽  
Pigment Epithelium ◽  
Retinal Pigment

scholarly journals Serum exosomal miR-377-3p inhibits retinal pigment epithelium proliferation and offers a biomarker for diabetic macular edema

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110029
Author(s):  
Li Jiang ◽  
He Cao ◽  
Tingming Deng ◽  
Mingming Yang ◽  
Ting Meng ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Luciferase Reporter ◽  
Characteristic Analysis ◽  
Vegf Expression ◽  
Mirna Profiling ◽  
Potential Biomarker

Objectives Diabetic macular edema (DME) is a complication of diabetes mellitus that leads to diabetic retinopathy. Thus far, the role of serum exosomal microRNAs (miRNAs) in DME progression remains elusive. This study investigated serum exosomal miRNAs from patients with type 2 diabetes (T2D) and DME to identify miRNAs associated with expression of vascular endothelial growth factor (VEGF), a pivotal component in DME progression; it also evaluated the diagnostic values of these miRNAs for DME. Methods Serum was collected from patients with T2D who did (n = 20) and did not have DME (n = 24). Exosomes were isolated from serum and subjected to real-time polymerase chain reaction, western blotting, luciferase reporter, and miRNA profiling analyses. Results VEGF was significantly upregulated in ARPE-19 cells treated with exosomes from patients with T2D and DME, compared with exosomes from patients with T2D alone. Among the top 10 downregulated miRNAs identified during exosomal miRNA profiling, miR-377-3p inhibited the expression of VEGF. Luciferase reporter assays confirmed that miR-377-3p could directly regulate VEGF expression. Receiver operating characteristic analysis identified serum exosomal miR-377-3p as a potential biomarker for DME. Conclusion Serum exosomal miR-377-3p inhibits VEGF expression to suppress retinal pigment epithelium proliferation and offers a diagnostic biomarker for DME.

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