scholarly journals Trehalose efficacy in dry eye syndrome therapy in diabetic patients

2016 ◽  
Vol 9 (2) ◽  
pp. 19-26 ◽  
Author(s):  
Niurguyana N Grigorieva ◽  
Maria E Peich ◽  
Fedor E Shadrichev
Keyword(s):  
Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Dry Eye ◽  
Metabolic Disorders ◽  
Dry Eye Syndrome ◽  
Diabetic Patients ◽  
Ocular Involvement ◽  
Active Population ◽  
Metabolism Disorder ◽  
Prevalence Of Diabetes Mellitus

The prevalence of diabetes mellitus with ocular involvement and that of dry eye syndrome constantly increase. As the result, the ophthalmologist has to deal more and more often with patients having signs of both pathological processes. Neuropathy, against the background of metabolic disorders in diabetes, is an additional factor promoting the aggravation of corneoconjunctival xerosis. A significant part of socially active population suffering from carbohydrate metabolism disorder needs a prescription of medications to correct symptoms as well as signs of the dry eye syndrome. The present article concentrates on investigating trehalose efficacy in dry eye syndrome treatment in diabetic patients.

scholarly journals “Hylabak” and “Theagel” use for dry eye syndrome in diabetic patients

2014 ◽  
Vol 7 (1) ◽  
pp. 28-33
Author(s):  
Niurguyana Nikolaevna Grigorieva ◽  
Mariya Viktorovna Panfilova ◽  
Elena Nikolaevna Stepanova ◽  
Fedor Evgenievich Shadrichev
Keyword(s):  
Dry Eye ◽  
Disease Incidence ◽  
Dry Eye Syndrome ◽  
Diabetic Patients ◽  
Metabolism Disorder ◽  
Number Of Patients ◽  
Prevalence Of Diabetes Mellitus ◽  
Metabolic Impairments

During last ten years the prevalence of diabetes mellitus significantly increased. Taking into consideration the role of metabolic impairments in the pathogenesis of diabetes and of dry eye syndrome, the increase in number of patients suffering from kerato-conjunctival xerosis on the background of carbohydrate metabolism disorder is highly predictive. This is favored also by the fact that type 2 diabetes, assuring the main increase in disease incidence, is constantly “rejuvenating”, more and more covering a substantial group of a socially-active part of population, which assumes a modern life-style with all the adverse effects accompanying hasty urbanization. The article is dedicated to the comprehensive dry eye syndrome treatment in diabetic patients.

scholarly journals “Keratrop” eye drops efficacy in dry eye syndrome treatment in diabetic patients

The Eye ◽  
2020 ◽  
Vol 22 (4(132)) ◽  
pp. 36-41
Author(s):  
F. A. Bakhritdinova ◽  
F. A. Haydarova ◽  
K. I. Narzikulova ◽  
I. F. Nabieva
Keyword(s):  
Diabetes Mellitus ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Diabetic Patients ◽  
Eye Drops ◽  
Artificial Tears ◽  
Antidiabetic Treatment ◽  
Patients With Diabetes

Significance. Prevalence of diabetes mellitus (DM) is increasing worldwide. People with diabetes are at higher risk to dry eye syndrome (DES). The increasing dependence of society on computers, air conditioning, and visual workload, etc. results in an increase in the manifestations of DES in diabetic patients. A significant part of the socially active population with diabetes requires prescription of drugs aimed at correcting disorders associated with both hyperglycemia and dry eyes. Conservative treatment of DES in case of diabetes includes prescription of artificial tears, metabolic, immunocorrecting, hormonal, antiallergic therapies as well as treatment of meibomian gland dysfunction (MGD). The tear substitutes, however, cannot always satisfy the needs of doctors and patients due to the imperfections of their formulas. Therefore, more and more new drugs are introduced to the market that require a comprehensive assessment.Purpose. To evaluate the clinical efficacy of Keratrop eye drops – a new artificial tear formulation – in dry eye syndrome treatment in patients with diabetes mellitus (DM).Methods. The study included 65 patients (130 eyes) with dry eye syndrome stages I and II associated with mild and moderate diabetes. These were adult patients of both sexes who had not previously received artificial tears as treatment and were undergoing either inpatient or domiciliary care. All studied patients provided a written informed consent and were divided into 2 groups by random sampling. The main group (35 patients) was receiving Keratrop instillations 2 times a day during 14 days, in the course of antidiabetic treatment. Instillations of “artificial tear” were not prescribed to patients of the control group (30 patients), and they only received antidiabetic treatment prescribed by the endocrinologist. Before and after treatment, all patients underwent standard ophthalmic examinations, meibography imaging, tear film assessment and filled in OSDI questionnaires.Results. The study showed that during treatment, in patients of the experimental group – with both I and II dry eye syndrome stages – a significant decrease in subjective and objective manifestations was observed, along with an improvement in the tear film stability. In the control group, positive dynamics was observed only in patients with the first stage of dry eye syndrome.Conclusion. Dry eye syndrome treatment in patients with diabetes should be comprehensive and must include both basic antidiabetic therapy and instillation of tear substitutes.

scholarly journals Dry eye syndrome in patients of diabetes with and without diabetic retinopathy

2018 ◽  
Vol 6 (3) ◽  
pp. 794
Author(s):  
Ashish Kumar Sharma ◽  
Ahmad Nadeem Aslami ◽  
Amit Kumar ◽  
Amresh Kumar ◽  
Rajeev Priyadarshi
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Diabetic Patients ◽  
Medical College ◽  
Rural And Urban ◽  
Body Sensation ◽  
Department Of Ophthalmology

Background: Diabetes Mellitus (DM) can lead to Diabetic retinopathy. Dry Eye Syndrome is commonly seen in diabetic patients. The purpose of this study was assessment of dry eye in patients with and without diabetic retinopathy.Methods: The study was conducted in the department of Ophthalmology and Rural and Urban centres of Community Medicine, Narayan Medical College and Hospital, Sasaram, Bihar. All cases of Type 2 diabetes mellitus over six months period were considered for the study. The diabetic patients were divided into two groups, one with diabetic retinopathy and others without diabetic retinopathy. All patients were subjected to McMonnie’s questionnaire and clinical evaluation including tear film studies like Schirmer’s test and Tear Film Break Up Time (TBUT).Results: 60 diabetic patients were enrolled for the study, 30 had evidence of diabetic retinopathy while 30 had no evidence. The most common dry eye symptom reported was foreign body sensation (96.7%). All Signs of dry eye disorder were found more commonly in patients with diabetic retinopathy as compared to those without diabetic retinopathy. Mcmonnie’s scores correlates well with both Schirmer’s basic secretion test (BST) and TBUT.Conclusions: Dry eye syndrome must be diagnosed in diabetic patients. Periodic screening of diabetic patients should be carried out to evaluate diabetic retinopathy and its complications. 

scholarly journals Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Xinyuan Zhang ◽  
Lin Zhao ◽  
Shijing Deng ◽  
Xuguang Sun ◽  
Ningli Wang
Keyword(s):  
Diabetes Mellitus ◽  
Dry Eye ◽  
Keratoconjunctivitis Sicca ◽  
Clinical Manifestations ◽  
Treatment Strategies ◽  
Dry Eye Syndrome ◽  
Surface System ◽  
Patients With Diabetes ◽  
Function Unit ◽  
Substantial Progress

There has been substantial progress in our understanding of the ocular surface system/lacrimal function unit in the past 15 years. Keratoconjunctivitis sicca, more commonly referred to as dry eye syndrome (DES), is the most frequently encountered condition and diabetes mellitus (DM) has been identified as one of the leading causes of DES. Poor glycemic control affects both the anterior and the posterior segments of the eye and increasing prevalence of diabetes-associated DES (DMDES) has been reported in recent years. The pathogenesis and specific features of DMDES remain uncertain and interventions are limited to those used in DES. This review outlines the pathogenesis, clinical manifestations, and the current preventive and treatment strategies for diabetes-related DES.

scholarly journals Diabetic Patients Who are Amateur Divers

2018 ◽  
Vol 64 (3) ◽  
pp. 39-44
Author(s):  
Daria Ługowska ◽  
Tomasz Ługowski ◽  
Olga Krzywińska ◽  
Mariusz Kozakiewicz ◽  
Paweł Grzelakowski
Keyword(s):  
Diabetes Mellitus ◽  
Risk Assessment ◽  
21St Century ◽  
Diabetic Patients ◽  
Sport Practice ◽  
High Prevalence ◽  
Prevalence Of Diabetes Mellitus

Abstract Diabetes is an “epidemic of the 21st century” and it is estimated that in 2011 6.7% of Poland’s population suffered from diabetes, one quarter of which was unaware of the disease. Such a high prevalence of diabetes mellitus results in an increasing number of physicians being confronted with the problem of qualifying patient with diabetes to partake in amateur sports, including diving. This publication presents the most important information concerning risk assessment, admission of diabetic patients to amateur diving and some proposed protocols of management before and during sport practice.

scholarly journals SUPERFICIAL CANDIDOSIS COURSE IN PATIENTS WITH CARBOHYDRATE METABOLISM DISORDER AND DIABETES MELLITUS

2019 ◽  
Vol 72 (1) ◽  
pp. 68-71
Author(s):  
Оrysya О. Syzon ◽  
Solomiya A. Turkevych ◽  
Tetyana I. Rudnyk ◽  
Svitlana V. Volbyn ◽  
Marianna O. Dashko
Keyword(s):  
Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Glycosylated Hemoglobin ◽  
Tolerance Test ◽  
Control Group ◽  
Clinical Tests ◽  
Metabolism Disorder ◽  
Mucous Membranes ◽  
Reliable Detection

Introduction: One of the pressing issues of modern dermatology is the prevalence of diseases of skin and mucous membranes caused by yeast-like fungi. The aim: To study specific features of the course of skin and mucous membranes superficial candidosis against the background of initial carbohydrate metabolism disorders or diabetes mellitus. Materials and methods: We have examined 93 patients aged 18-75 suffering from superficial candidosis. Candidosis was diagnosed based on anamnesis data, results of clinical tests and laboratory studies. The study of carbohydrate metabolism included determining of the glucose level under fasting conditions to establish possible diabetes mellitus and glucose tolerance test (75 g glucose load), glycosylated hemoglobin (HbA1c) and fructosamine (FR). Results: In patients with mild and moderate candidosis we have detected an increased rates of НbA1с and fructosamine, as compared with the like indicators received in the control group, by 1.54 and 1.21 times respectively. In patients with severe candidosis and relapses the concentrations of НbA1с increased by 2.59 times, FR – by 2.26 times against the indicators received in the control group. Thus, increased levels of blood glycosylated protein indicate the pathogenetic importance of these processes in the development of candidosis. Conclusions: Consequently, increased levels of blood glycosylated protein indicates the pathogenetic importance of these processes in the development of candidal lesions. Tests for НbA1с and FR proved to be sensitive and allow reliable detection of individuals with diabetes mellitus and glucose intolerance among candidosis patients.

scholarly journals Extent of awareness regarding periodontal disease in diabetic patients among medical interns

2015 ◽  
Vol 05 (04) ◽  
pp. 017-021
Author(s):  
Roshni Jaiswal ◽  
Nina Shenoy ◽  
Biju Thomas
Keyword(s):  
Diabetes Mellitus ◽  
Periodontal Disease ◽  
Strong Relationship ◽  
Diabetic Patients ◽  
Significant Finding ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Medical Interns ◽  
Relationship Of ◽  
Prevalence Of Diabetes Mellitus

Abstract Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to defective secretion or activity of insulin Prevalence of diabetes mellitus has tripled since 1970, hence it is a significant finding for dental professionals, as evidence from clinical research showing a strong relationship between diabetes and periodontal disease is mounting. In fact, periodontitis is often referred to as the sixth complication of diabetes. Objective : To assess the extent of awareness of periodontal disease in diabetic patients, among medical interns. Methods: A cross sectional survey containing 21 questions was answered by 150 medical interns from Mangalore, Karntaka. Conclusion: The results of this survey indicate that medical interns have thorough knowledge about diabetes and its complications; however, their awareness about periodontal disease in diabetic patients is limited thus further emphasis should be given to the dissemination of knowledge about the inter-relationship of diabetes and periodontal health.

Dynamics of metabolic characteristics, markers of oxidative stress and vascular wall damage during treatment of obese prediabetic patients

2016 ◽  
Vol 94 (3) ◽  
pp. 221-224
Author(s):  
Irina A. Romanenko ◽  
T. S. Polyatykina ◽  
N. V. Mavrycheva ◽  
N. V. Budnikova ◽  
V. B. Grinshtein
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Malonic Dialdehyde ◽  
Vascular Wall ◽  
Metabolic Parameters ◽  
Diabetic Patients ◽  
Metabolic Characteristics ◽  
Before And After ◽  
Markers Of Oxidative Stress

We studied lipid and carbohydrate metabolism, markers of oxidative stress (plasma malonic dialdehyde and dienoic conjugates) and vascular wall damage (CRP, microalbuminuria, blood desquamated endotheliocytes) before and after 12 week treatment of obese pre-diabetic patients. The study showed positive dynamics of the above metabolic parameters with normalization of carbohydrate metabolism in 60% of the patients and angioprotective effect ofprescribed therapy. The proposed treatment can be used to prevent diabetes mellitus.

scholarly journals Type 2 Diabetes Mellitus in urban and rural districts in the area of Wolisso Hospital, Ethiopia

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Madia ◽  
M Soprana ◽  
A Mele ◽  
C Kadhim ◽  
N Binello ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Rural Districts ◽  
Glycemic Target ◽  
Insulin Storage ◽  
Prevalence Of Diabetes Mellitus ◽  
Type 2 Diabetic

Abstract The prevalence of Diabetes Mellitus has been rapidly growing in developing countries, both in urban and rural contexts. Ethiopia has the largest diabetes population in sub-Saharan Africa (2.6 million adult people). At Wolisso Hospital, a collaboration is underway between Doctors with Africa CUAMM and the local Association of Diabetic Patients, with the aim of guaranteeing the correct monitoring and treatment of the disease. Between December 2018 and May 2019, 244 diabetic patients were visited in a dedicated outpatient room in Wolisso Hospital; in 55 selected patients (type 2 Diabetes Mellitus, ≥ 2 visits in the 6 months, on insulin therapy), a further set of variables was measured, including: modality of insulin storage, monthly glycemic measurements, compliance with prescribed therapy, glycemic control, knowledge of glycemic target. Based on their urban or rural provenience, patients were split in two groups (27 urban, 28 rural). The χ2-test was used to determine significance. P ≤ 0.05 was considered statistically significant. A statistically significant difference was reported for the following variables: availability of a fridge for insulin storage (51.9% urban vs 21.4% rural, p = 0.039), compliance with prescribed therapy (63.0% urban vs 35.7% rural, p = 0.043), prevalence of hypertension (55.6% urban vs 28.6% rural, p = 0.043), alcohol consumption (32.1% rural vs 11.1% urban, p = 0.018). 13/27 urban patients and 21/28 rural patients reported that they stored insulin in the sand. No substantial variation between the groups is observed for BMI, glycemic control, number of monthly glycemic measurements and knowledge of glycemic target. The differences highlighted between type 2 diabetic patients from urban and rural districts of the area of Wolisso suggest that these populations probably have different features and risk factors; this consideration may be useful in the organization of specific public health interventions aimed at addressing the issue in the different settings. Key messages The prevalence of Diabetes Mellitus has been rapidly growing in developing countries, both in urban and rural contexts. The differences highlighted between type 2 diabetic patients from urban and rural districts of the area of Wolisso suggest that these populations probably have different features and risk factors.

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