Structural and dynamic features of verbal hallucinosis in organic lesions of the frontal region of the brain

2003 ◽  
Vol XXXV (1-2) ◽  
pp. 68-69
Author(s):  
S. V. Afanasiev ◽  
D. M. Mendelevich
Keyword(s):  
Mental Disorders ◽  
Frontal Lobes ◽  
Auditory Hallucinations ◽  
Frontal Region ◽  
Dynamic Features ◽  
Focal Lesions ◽  
Organic Brain ◽  
The Impact ◽  
The Brain ◽  
Organic Lesions

A large number of works are devoted to the problem of studying auditory hallucinations. However, it would be wrong to believe that the issues related to this problem have been finally resolved. So, the features of auditory hallucinations in organic brain damage of various localization, in particular the frontal region, have not been sufficiently studied. Focal lesions of the frontal region are characterized by a variety of mental disorders related to the pathology of not only individual aspects of mental activity, but also consciousness and personality. The defeat of the frontal lobes is accompanied by disorders not only of the direct functions of this area, but also of other cerebral systems that disrupt their work due to changes in the impact of frontal mechanisms on these systems. With the defeat of the frontal lobes, hallucinations of various modalities occur, which are true. They usually arise simultaneously in several areas of the senses - auditory, olfactory, visual. Until now, data on auditory hallucinations in organic lesions of the frontal region of the brain, firstly, have not been generalized, and secondly, they have not been systematized.

scholarly journals Stigma Masyarakat Terhadap Gangguan Jiwa: Literature Review

2021 ◽  
Vol 1 ◽  
pp. 207-216
Author(s):  
Ade Apriliana ◽  
Hana Nafiah
Keyword(s):  
Mental Disorders ◽  
Literature Review ◽  
Social Stigma ◽  
Self Esteem ◽  
Mental Illness Stigma ◽  
Average Score ◽  
Average Value ◽  
The Social ◽  
The Impact ◽  
The Brain

AbstractMental disorders are disorders that occur in the brain which are characterized by distrurbed behavior, thinking processes, emotions, and perceptions. The stigma attached to people with mental disorders is still a problem. The impact of stigma given to people with mental disorders can cause sufferers to lose self-esteem. This study aimed to determine the description of the social stigma of mental disorders in a literature review. This reseach was a literature review research. This articles found were searched from the online database, namely Pubmed. There were five articles that matched the research inclusion criteria. The total number of respondents was 1,874. Critical analysis of the articles used the Hawker instrumen. The results showed that there were four articles which have a negative stigma. Only one article had a positive stigma. The average score of the Authoritariansm aspect was 6.53. The average score of the Benevolence aspect was 6.27. The Social aspects Restrictiveness had an average value of 5.87. The average score of the CMHI was 5.73. Meanwhile, in the positive stigma article, the hight stigma value was 44.04% an the low stigma was 26.97%. Based on the results, it can be concluded that there are negative stigma results for people with mental disordesKeywords: Mental disorders; public; mental illnes; stigma AbstrakGangguan Jiwa adalah gangguan yang terjadi pada otak yang ditandai dengan terganggunya perilaku, proses berfikir, emosi, dan persepsi. Stigma yang melekat pada orang dengan gangguan jiwa masih menjadi suatu masalah. Dampak dari stigma yang diberikan pada orang dengan gangguan jiwa, dapat menyebabkan penderita kehilangan self esteem. Penelitian ini bertujuan untuk mengetahui gambaran stigma masyarakat terhadap gangguan jiwa secara literature review. Penelitian ini adalah penelitian literature review. Hasil pencarian artikel dari database online yaitu Pubmed yang didapatkan 5 artikel yang sesuai dengan kriteria inklusi penelitian, dengan hasil jumlah responden 1.874. Analisa telaah kritis terhadap 5 artikel menggunakan instrumen Hawker. Secara umum hasil analisa 4 artikel mempunyai stigma yang negatif dan 1 artikel mempunyai stigma yang positif dengan hasil analisa pada 4 artikel, aspekauthoritariansm dengan rata-rata nilai 6,53, aspek benevolencee dengan rata-rata nilai 6,27, aspek social restrictiveness dengan rata-rata nilai 5,87, dan aspek Community Mental Health Ideology (CMHI) dengan nilai rata-rata 5,73. Dan berdasarkan satu artikel didapatkan nilai stigma tinggi yaitu sebanyak 44.04% dan stigma rendah 26,97%. Hasil penelitian literature review ini menyimpulkan bahwa didapatkan hasil stigma yang negatif terhadap orang dengan gangguan jiwa.Kata Kunci :Gangguan jiwa, masyarakat, mental disorders, mental illness, stigma

Epigenetic Studies in Psychotherapy: A Systematic Review

2020 ◽  
Vol 16 (2) ◽  
pp. 86-92
Author(s):  
Rafael Penadés ◽  
Bárbara Arias ◽  
Mar Fatjó-Vilas ◽  
Laura González-Vallespí ◽  
Clemente García-Rizo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Mental Disorders ◽  
Epigenetic Modifications ◽  
Symptom Improvement ◽  
Epigenetic Changes ◽  
Main Hypothesis ◽  
Psychological Treatments ◽  
Time Period ◽  
The Impact

Background: Epigenetic modifications appear to be dynamic and they might be affected by environmental factors. The possibility of influencing these processes through psychotherapy has been suggested. Objective: To analyse the impact of psychotherapy on epigenetics when applied to mental disorders. The main hypothesis is that psychological treatments will produce epigenetic modifications related to the improvement of treated symptoms. Methods: A computerised and systematic search was completed throughout the time period from 1990 to 2019 on the PubMed, ScienceDirect and Scopus databases. Results: In total, 11 studies were selected. The studies were evaluated for the theoretical framework, genes involved, type of psychotherapy and clinical challenges and perspectives. All studies showed detectable changes at the epigenetic level, like DNA methylation changes, associated with symptom improvement after psychotherapy. Conclusion: Methylation profiles could be moderating treatment effects of psychotherapy. Beyond the detected epigenetic changes after psychotherapy, the epigenetic status before the implementation could act as an effective predictor of response.

scholarly journals A Comparative Analysis on Probability of Volatility Clusters on Cryptocurrencies, and FOREX Currencies

2021 ◽  
Vol 14 (7) ◽  
pp. 308
Author(s):  
Usha Rekha Chinthapalli
Keyword(s):  
Investment Decision ◽  
Theoretical Work ◽  
Financial Asset ◽  
Dynamic Features ◽  
Asset Return ◽  
Financial Variables ◽  
Ann Models ◽  
Hidden Layer ◽  
Association Structure ◽  
The Impact

In recent years, the attention of investors, practitioners and academics has grown in cryptocurrency. Initially, the cryptocurrency was designed as a viable digital currency implementation, and subsequently, numerous derivatives were produced in a range of sectors, including nonmonetary activities, financial transactions, and even capital management. The high volatility of exchange rates is one of the main features of cryptocurrencies. The article presents an interesting way to estimate the probability of cryptocurrency volatility clusters. In this regard, the paper explores exponential hybrid methodologies GARCH (or EGARCH) and through its portrayal as a financial asset, ANN models will provide analytical insight into bitcoin. Meanwhile, more scalable modelling is needed to fit financial variable characteristics such as ANN models because of the dynamic, nonlinear association structure between financial variables. For financial forecasting, BP is contained in the most popular methods of neural network training. The backpropagation method is employed to train the two models to determine which one performs the best in terms of predicting. This architecture consists of one hidden layer and one input layer with N neurons. Recent theoretical work on crypto-asset return behavior and risk management is supported by this research. In comparison with other traditional asset classes, these results give appropriate data on the behavior, allowing them to adopt the suitable investment decision. The study conclusions are based on a comparison between the dynamic features of cryptocurrencies and FOREX Currency’s traditional mass financial asset. Thus, the result illustrates how well the probability clusters show the impact on cryptocurrency and currencies. This research covers the sample period between August 2017 and August 2020, as cryptocurrency became popular around that period. The following methodology was implemented and simulated using Eviews and SPSS software. The performance evaluation of the cryptocurrencies is compared with FOREX currencies for better comparative study respectively.

scholarly journals Socio-economic consequences of mental distress: quantifying the impact of self-reported mental distress on the days of incapacity to work and medical costs in a two-year period: a longitudinal study in Germany

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gerhard Müller ◽  
Manuela Bombana ◽  
Monika Heinzel-Gutenbrenner ◽  
Nikolaus Kleindienst ◽  
Martin Bohus ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Mental Distress ◽  
Linear Models ◽  
Longitudinal Research ◽  
Depression Scale ◽  
Routine Data ◽  
Medical Costs ◽  
First Year ◽  
Second Year ◽  
The Impact

Abstract Background Mental disorders are related to high individual suffering and significant socio-economic burdens. However, it remains unclear to what extent self-reported mental distress is related to individuals’ days of incapacity to work and their medical costs. This study aims to investigate the impact of self-reported mental distress for specific and non-specific days of incapacity to work and specific and non-specific medical costs over a two-year span. Method Within a longitudinal research design, 2287 study participants’ mental distress was assessed using the Hospital Anxiety and Depression Scale (HADS). HADS scores were included as predictors in generalized linear models with a Tweedie distribution with log link function to predict participants’ days of incapacity to work and medical costs retrieved from their health insurance routine data during the following two-year period. Results Current mental distress was found to be significantly related to the number of specific days absent from work and medical costs. Compared to participants classified as no cases by the HADS (2.6 days), severe case participants showed 27.3-times as many specific days of incapacity to work in the first year (72 days) and 10.3-times as many days in the second year (44 days), and resulted in 11.4-times more medical costs in the first year (2272 EUR) and 6.2-times more in the second year (1319 EUR). The relationship of mental distress to non-specific days of incapacity to work and non-specific medical costs was also significant, but mainly driven from specific absent days and specific medical costs. Our results also indicate that the prevalence of presenteeism is considerably high: 42% of individuals continued to go to work despite severe mental distress. Conclusions Our results show that self-reported mental distress, assessed by the HADS, is highly related to the days of incapacity to work and medical costs in the two-year period. Reducing mental distress by improving preventive structures for at-risk populations and increasing access to evidence-based treatments for individuals with mental disorders might, therefore, pay for itself and could help to reduce public costs.

scholarly journals Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 892
Author(s):  
Elisa L. J. Moya ◽  
Elodie Vandenhaute ◽  
Eleonora Rizzi ◽  
Marie-Christine Boucau ◽  
Johan Hachani ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Blood Brain Barrier ◽  
Early Stage ◽  
Molecular Transport ◽  
Brain Barrier ◽  
Blood Brain ◽  
Cns Drugs ◽  
The Impact ◽  
The Brain

Central nervous system (CNS) diseases are one of the top causes of death worldwide. As there is a difficulty of drug penetration into the brain due to the blood–brain barrier (BBB), many CNS drugs treatments fail in clinical trials. Hence, there is a need to develop effective CNS drugs following strategies for delivery to the brain by better selecting them as early as possible during the drug discovery process. The use of in vitro BBB models has proved useful to evaluate the impact of drugs/compounds toxicity, BBB permeation rates and molecular transport mechanisms within the brain cells in academic research and early-stage drug discovery. However, these studies that require biological material (animal brain or human cells) are time-consuming and involve costly amounts of materials and plastic wastes due to the format of the models. Hence, to adapt to the high yields needed in early-stage drug discoveries for compound screenings, a patented well-established human in vitro BBB model was miniaturized and automated into a 96-well format. This replicate met all the BBB model reliability criteria to get predictive results, allowing a significant reduction in biological materials, waste and a higher screening capacity for being extensively used during early-stage drug discovery studies.

scholarly journals The Impact of Bone on the Biology of Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
Gerard Karsenty
Keyword(s):  
Muscle Function ◽  
Male Fertility ◽  
Leydig Cells ◽  
Memory Loss ◽  
Age Related ◽  
Systematic Exploration ◽  
Biology Of Aging ◽  
The Impact ◽  
The Brain ◽  
Regulate Energy Metabolism

Abstract We hypothesized that bone may secrete hormones that regulate energy metabolism and reproduction. Testing this hypothesis revealed that the osteoblast-specific secreted protein osteocalcin is a hormone regulating glucose homeostasis and male fertility by signaling through a GPCR, Gprc6a, expressed in pancreatic β bells and Leydig cells of the testes. The systematic exploration of osteocalcin biology, revealed that it regulates an unexpectedly large spectrum of physiological functions in the brain and peripheral organs and that it has most features of an antigeromic molecule. As will be presented at the meeting, this body of work suggests that harnessing osteocalcin for therapeutic purposes may be beneficial in the treatment of age-related diseases such as depression, age-related memory loss and the decline in muscle function seen in sarcopenia.

scholarly journals Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 340
Author(s):  
Lehel Balogh ◽  
Masaru Tanaka ◽  
Nóra Török ◽  
László Vécsei ◽  
Shigeru Taguchi
Keyword(s):  
Anxiety Disorders ◽  
Biological Treatment ◽  
Sense Of Self ◽  
Phenomenological Approach ◽  
Neurological Damage ◽  
Mood And Anxiety Disorders ◽  
New Interpretation ◽  
And Behavior ◽  
The Impact ◽  
The Brain

Psychotherapy is a comprehensive biological treatment modifying complex underlying cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with mental illness to a new interpretation of the sense of self and others. Psychotherapy is an art of science integrated with psychology and/or philosophy. Neurological sciences study the neurological basis of cognition, memory, and behavior as well as the impact of neurological damage and disease on these functions, and their treatment. Both psychotherapy and neurological sciences deal with the brain; nevertheless, they continue to stay polarized. Existential phenomenological psychotherapy (EPP) has been in the forefront of meaning-centered counseling for almost a century. The phenomenological approach in psychotherapy originated in the works of Martin Heidegger, Ludwig Binswanger, Medard Boss, and Viktor Frankl, and it has been committed to accounting for the existential possibilities and limitations of one’s life. EPP provides philosophically rich interpretations and empowers counseling techniques to assist mentally suffering individuals by finding meaning and purpose to life. The approach has proven to be effective in treating mood and anxiety disorders. This narrative review article demonstrates the development of EPP, the therapeutic methodology, evidence-based accounts of its curative techniques, current understanding of mood and anxiety disorders in neurological sciences, and a possible converging path to translate and integrate meaning-centered psychotherapy and neuroscience, concluding that the EPP may potentially play a synergistic role with the currently prevailing medication-based approaches for the treatment of mood and anxiety disorders.

scholarly journals Agency, Responsibility, Selves, and the Mechanical Mind

Philosophies ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Fiorella Battaglia
Keyword(s):  
Philosophy Of Technology ◽  
Extended Mind ◽  
Human Machine Interaction ◽  
Person Perspective ◽  
Legal Perspective ◽  
Area Of Concern ◽  
Third Person Perspective ◽  
The Mind ◽  
The Impact ◽  
The Brain

Moral issues arise not only when neural technology directly influences and affects people’s lives, but also when the impact of its interventions indirectly conceptualizes the mind in new, and unexpected ways. It is the case that theories of consciousness, theories of subjectivity, and third person perspective on the brain provide rival perspectives addressing the mind. Through a review of these three main approaches to the mind, and particularly as applied to an “extended mind”, the paper identifies a major area of transformation in philosophy of action, which is understood in terms of additional epistemic devices—including a legal perspective of regulating the human–machine interaction and a personality theory of the symbiotic connection between human and machine. I argue this is a new area of concern within philosophy, which will be characterized in terms of self-objectification, which becomes “alienation” following Ernst Kapp’s philosophy of technology. The paper argues that intervening in the brain can affect how we conceptualize the mind and modify its predicaments.

scholarly journals Low Birth Weight Prevalence in Children Diagnosed with Neurodevelopmental Disorders in Dubai

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110317
Author(s):  
Faisal A. Nawaz ◽  
Meshal A. Sultan
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Mental Disorders ◽  
Low Birth Weight ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
High Birth Weight ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
The Impact

The aim of this study is to evaluate the prevalence of low birth weight and other perinatal risk factors in children diagnosed with neurodevelopmental disorders. This is one of the first studies in the Arabian Gulf region focused on the contribution of these factors toward the development of various disorders such as attention-deficit/hyperactivity disorder, autism spectrum disorder, and other mental disorders. This descriptive study was based on qualitative data analysis. We reviewed retrospective information from the electronic medical records of 692 patients in Dubai, United Arab Emirates. The prevalence of low birth weight in children with mental disorders was significantly higher as compared to the general population (16% vs 6% respectively). Furthermore, other risk factors, including high birth weight and preterm birth were noted to have a significant association with neurodevelopmental disorders. Future research on the impact of perinatal risk factors will contribute to advancement of early intervention guidelines.

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