scholarly journals Generated potentials of brain in patients with intermittent torticollis

2001 ◽  
Vol XXXIII (3-4) ◽  
pp. 34-39
Author(s):  
L. Zh. Mindubajeva ◽  
G. A. Ivanichev ◽  
E. Sh. Bashirova
Keyword(s):  
Functional Activity ◽  
Sensory Systems ◽  
Peak Latency ◽  
Sensory Signal ◽  
Amplitude Increase ◽  
Amplitude Decrease ◽  
Interpeak Interval

For finding out a role of different afferent systems in processing a sensory signal it was performed an investigation of brain generated potentials in patients with intermittent torticollis. There had been studied acoustic truncus cerebri generated potentials and somato-sensory generated potentials. The acoustic truncus cerebri generated potentials were characterized by amplitude decrease, peak flatenning and by interpeak interval assymetry, while somato-sensory generated potentials - by amplitude increase of main peaks, peak latency assymetry. The obtained results give an opportunity to determine a functional activity of different sensory systems of brain in the structure of hyperkinesis.

The role of neurohumours in early embryogenesis

Development ◽  
1970 ◽  
Vol 23 (3) ◽  
pp. 549-569
Author(s):  
G. A. Buznikov ◽  
A. N. Kost ◽  
N. F. Kucherova ◽  
A. L. Mndzhoyan ◽  
N. N. Suvorov ◽  
...  
Keyword(s):  
Sea Urchin ◽  
Functional Activity ◽  
Early Onset ◽  
Active Sites ◽  
Physiological Effect ◽  
Early Embryogenesis ◽  
Dopamine Synthesis ◽  
Direct Involvement ◽  
Misgurnus Fossilis

In previous papers (Buznikov, Chudakova & Zvezdina, 1964; Buznikov, Chudakova, Berdysheva & Vyazmina, 1968) we reported that fertilized eggs of the sea-urchin Strongylocentrotus dröbachiensis synthesized a number of neurohumours, such as serotonin (5-hydroxytryptamine, 5-HT), acetylcholine (ACh), adrenalin (A), noradrenalin (NA) and dopamine. Synthesis of 5-HT was also demonstrated in the fertilized eggs of the loach Misgurnus fossilis and some marine Invertebrata. In experiments with sea-urchin embryos we were able to trace regular changes in the level of 5-HT, ACh, A and NA, related to the first cleavage divisions. This early onset of neurohumour synthesis, as well as regular changes in their level, suggests their direct involvement in the regulation of the first cleavage divisions. The functional activity of neurohumours (M) in adult organisms is realized through their reaction with the active sites of corresponding receptors (R) according to the following equation:The magnitude of the physiological effect under certain conditions is linearly proportional to the number of complexes MR formed (Turpayev, 1962; Ariëns, 1964).

Role of Functional Activity of Phagocytic Mononuclear System in the Formation of Autoprostheses for Angioplasty

2005 ◽  
Vol 140 (2) ◽  
pp. 217-218
Author(s):  
V. A. Chereshnev ◽  
N. V. Tyumentseva ◽  
B. G. Yushkov ◽  
I. G. Danilova ◽  
V. V. Khodakov ◽  
...  
Keyword(s):  
Functional Activity

Abstract 20627: Modulation of Cardiac Sodium Channel by Palmitoylation and Its Association With Cardiac Disease Mutations

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Zifan Pei ◽  
Andy Hudmon ◽  
Theodore R Cummins
Keyword(s):  
Steady State ◽  
Sodium Channel ◽  
Functional Activity ◽  
Site Directed Mutagenesis ◽  
Significant Shift ◽  
Biophysical Properties ◽  
Disease Mutations ◽  
Cardiac Sodium Channel ◽  
Steady State Inactivation

Cardiac sodium channel (Nav1.5) is responsible for the generation and propagation of the cardiac action potential, which underlies cardiac excitability. It can be modified by a variety of post-translational modifications. Palmitoylation is one of the most common post-translational lipid modifications that can dynamically regulate protein life cycle and functional activity. In our study, we identified palmitoylation on Nav1.5 and its alteration in channel biophysical properties. Nav1.5 palmitoylation was identified in both HEK 293 cells stably expressing Nav1.5 and cardiac tissues using acyl-biotin exchange assay. Nav1.5 palmitoylation was inhibited by pre-incubating the cells with the inhibitor 2-Br-Palmitate (2BP, 25uM, 24hrs). Biophysically, 2BP treatment drastically shifted the channel steady-state inactivation to more hyperpolarized voltages, suggesting palmitoylation altering channel functional activity. In addition, four predicted endogenous palmitoylation sites were identified using CSS-Palm 3.0. Site-directed mutagenesis method was used to generate a cysteine removing background of wt Nav1.5 to study the role of predicted sites. Patch clamp analysis of wt and cysteine-removed Nav1.5 revealed a significant change in channel biophysics. 2BP treatment significantly shifted steady-state inactivation of wt Nav1.5 while not affecting cysteine-removed Nav1.5 significantly, indicating the important role of these four cysteine sites in modulating channel palmitoylation. Moreover, several LQT disease mutations were identified to potentially add or remove palmitoylation sites. Further analysis of these disease mutations revealed a significant shift in channel steady-state inactivation and this alteration cannot be seen with the substitution of other residues on the same site, suggesting the specific role of cysteine residue in causing the functional alteration. For the LQT mutation that removes potential palmitoylation site, 2BP treatment did not affect channel biophysical properties, indicating the essential role of this cysteine in channel palmitoylation. These results suggest that palmitoylation on Nav1.5 regulates channel functional activity and its modulation may contribute to new cardiac channelopathies.

Coding Principles in Adaptation

2019 ◽  
Vol 5 (1) ◽  
pp. 427-449 ◽  
Author(s):  
Alison I. Weber ◽  
Kamesh Krishnamurthy ◽  
Adrienne L. Fairhall
Keyword(s):  
Nervous System ◽  
Visual System ◽  
Functional Role ◽  
Receptive Fields ◽  
Sensory Systems ◽  
Spike Frequency Adaptation ◽  
Theoretical Frameworks ◽  
Different Types ◽  
Common Principle

Adaptation is a common principle that recurs throughout the nervous system at all stages of processing. This principle manifests in a variety of phenomena, from spike frequency adaptation, to apparent changes in receptive fields with changes in stimulus statistics, to enhanced responses to unexpected stimuli. The ubiquity of adaptation leads naturally to the question: What purpose do these different types of adaptation serve? A diverse set of theories, often highly overlapping, has been proposed to explain the functional role of adaptive phenomena. In this review, we discuss several of these theoretical frameworks, highlighting relationships among them and clarifying distinctions. We summarize observations of the varied manifestations of adaptation, particularly as they relate to these theoretical frameworks, focusing throughout on the visual system and making connections to other sensory systems.

Role of Ca2+in the Electrostatic Stability and the Functional Activity of the Globular Domain of Human C1q†

Biochemistry ◽  
2005 ◽  
Vol 44 (43) ◽  
pp. 14097-14109 ◽  
Author(s):  
Lubka T. Roumenina ◽  
Alexandar A. Kantardjiev ◽  
Boris P. Atanasov ◽  
Patrick Waters ◽  
Mihaela Gadjeva ◽  
...  
Keyword(s):  
Functional Activity ◽  
Globular Domain ◽  
Electrostatic Stability

scholarly journals The role of sucrose and sensory systems in fruit selection and consumption ofAteles geoffroyiin Yucatan, Mexico

2015 ◽  
Vol 31 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Miriam Pablo-Rodríguez ◽  
Laura Teresa Hernández-Salazar ◽  
Filippo Aureli ◽  
Colleen M. Schaffner
Keyword(s):  
Sucrose Concentration ◽  
Sensory Systems ◽  
Spider Monkeys ◽  
Sensory Cues ◽  
Sense Of Smell ◽  
Fruit Samples ◽  
The Senses ◽  
The Difference ◽  
Unripe Fruits

Abstract:Our aim was to evaluate the role of sucrose and the role of smell, taste and touch in the selection and consumption of fruit in wild spider monkeys. We recorded the feeding bouts of 14 adults for 9 mo in the Otoch Ma’ax Yetel Kooh Reserve, Punta Laguna, Yucatan, Mexico. For each of 2346 inspections on fruits of six species the consumption or rejection and the use of touch, smell and taste was recorded. Ten fruit samples (five ripe and five unripe) from each species were collected and the sucrose concentration was determined with a refractometer. As expected, sucrose concentrations were higher in ripe than unripe fruits. The difference in sucrose concentration between ripe and unripe fruits was positively associated with the proportion of inspections on ripe fruits and the proportion of consumed ripe fruits. Furthermore, the senses of touch and taste were used more often when fruits were ripe, whereas the sense of smell was used more often when fruits were unripe. The results suggest that sensory cues and sucrose concentration play important roles in fruit selection in spider monkeys.

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