scholarly journals About multinucleated sympathetic nerve cells

1904 ◽  
Vol XII (4) ◽  
pp. 127-145
Author(s):  
I. V. Georgievskiy
Keyword(s):  
Nervous System ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Nerve Cells ◽  
Historical Society

In 1834, at a meeting of the Strasbourg Natural-Historical Society, Lauth made a report on the results of his research on the organization of the nervous system, in which, it seems, the first mention of the presence between the nerve fibers n. sympathici of round accumulations of granular substance, similar to that found in ganglia intervertebralia.

scholarly journals The relationship between the borderline trunk of the sympathetic nerve and the central nervous system

2020 ◽  
Vol VII (2) ◽  
pp. 55-59
Author(s):  
S. A. Trushkovskiy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship ◽  
Further Development

The question of the relationship of the borderline trunk of the sympathetic nerve to the central nervous system is almost completely undeveloped until the present time, and only recently, thanks to the improvement of methods for studying nerve fibers, it became possible for a more accurate further development of this issue.

The musculature and nervous system of the plerocercoid larva of Dibothriorhynchus grossum (Rud.)

Parasitology ◽  
1941 ◽  
Vol 33 (4) ◽  
pp. 373-389 ◽  
Author(s):  
Gwendolen Rees
Keyword(s):  
Nervous System ◽  
Muscle Mass ◽  
Nerve Cells ◽  
The Body ◽  
Lateral Nerve ◽  
Posterior Median ◽  
The Brain ◽  
Ventral Muscle ◽  
Nerve Cords ◽  
Extrinsic Muscles

1. The structure of the proboscides of the larva of Dibothriorhynchus grossum (Rud.) is described. Each proboscis is provided with four sets of extrinsic muscles, and there is an anterior dorso-ventral muscle mass connected to all four proboscides.2. The musculature of the body and scolex is described.3. The nervous system consists of a brain, two lateral nerve cords, two outer and inner anterior nerves on each side, twenty-five pairs of bothridial nerves to each bothridium, four longitudinal bothridial nerves connecting these latter before their entry into the bothridia, four proboscis nerves arising from the brain, and a series of lateral nerves supplying the lateral regions of the body.4. The so-called ganglia contain no nerve cells, these are present only in the posterior median commissure which is therefore the nerve centre.

scholarly journals Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections.

1983 ◽  
Vol 96 (5) ◽  
pp. 1337-1354 ◽  
Author(s):  
P De Camilli ◽  
R Cameron ◽  
P Greengard
Keyword(s):  
Nervous System ◽  
Detailed Examination ◽  
Specific Protein ◽  
Nerve Cells ◽  
General Distribution ◽  
Synapsin I ◽  
Nervous Systems ◽  
Synaptic Region ◽  
Specific Localization ◽  
Peripheral Nervous Systems

Synapsin I (formerly referred to as protein I) is the collective name for two almost identical phosphoproteins, synapsin Ia and synapsin Ib (protein Ia and protein Ib), present in the nervous system. Synapsin I has previously been shown by immunoperoxidase studies (De Camilli, P., T. Ueda, F. E. Bloom, E. Battenberg, and P. Greengard, 1979, Proc. Natl. Acad. Sci. USA, 76:5977-5981; Bloom, F. E., T. Ueda, E. Battenberg, and P. Greengard, 1979, Proc. Natl. Acad. Sci. USA 76:5982-5986) to be a neuron-specific protein, present in both the central and peripheral nervous systems and concentrated in the synaptic region of nerve cells. In those preliminary studies, the occurrence of synapsin I could be demonstrated in only a portion of synapses. We have now carried out a detailed examination of the distribution of synapsin I immunoreactivity in the central and peripheral nervous systems. In this study we have attempted to maximize the level of resolution of immunohistochemical light microscopy images in order to estimate the proportion of immunoreactive synapses and to establish their precise distribution. Optimal results were obtained by the use of immunofluorescence in semithin sections (approximately 1 micron) prepared from Epon-embedded nonosmicated tissues after the Epon had been removed. Our results confirm the previous observations on the specific localization of synapsin I in nerve cells and synapses. In addition, the results strongly suggest that, with a few possible exceptions involving highly specialized neurons, all synapses contain synapsin I. Finally, immunocytochemical experiments indicate that synapsin I appearance in the various regions of the developing nervous system correlates topographically and temporally with the appearance of synapses. In two accompanying papers (De Camilli, P., S. M. Harris, Jr., W. B. Huttner, and P. Greengard, and Huttner, W. B., W. Schiebler, P. Greengard, and P. De Camilli, 1983, J. Cell Biol. 96:1355-1373 and 1374-1388, respectively), evidence is presented that synapsin I is specifically associated with synaptic vesicles in nerve endings.

Amitriptyline Neurotoxicity

2004 ◽  
Vol 100 (6) ◽  
pp. 1519-1525 ◽  
Author(s):  
Jean-Pierre Estebe ◽  
Robert R. Myers
Keyword(s):  
Nervous System ◽  
Sciatic Nerve ◽  
Local Anesthetic ◽  
Dose Range ◽  
Antidepressant Drug ◽  
Nerve Fibers ◽  
Anesthetic Agent ◽  
Sprague Dawley ◽  
Neurotoxic Effect ◽  
Local Anesthetic Agent

Background Amitriptyline is a tricyclic antidepressant drug used systemically for the management of neuropathic pain. Antidepressants, as a class of drugs with direct neurologic actions, are becoming widely used for the management of chronic pain, although their mechanisms are not entirely understood. Amitriptyline exerts potent effects on reuptake of norepinephrine and serotonin and blocks alpha 2A adrenoreceptors and N-methyl-D-aspartate receptors. Because amitriptyline is also a particularly potent blocker of sodium channels and voltage-gated potassium and calcium channels, it has been recommended as a long-acting local anesthetic agent. Unfortunately, amitriptyline has significant toxic side effects in the central nervous system and cardiovascular system that are dose-related to its systemic administration. Therefore, before amitriptyline can be used clinically as a local anesthetic agent, it should be thoroughly explored with respect to its direct neurotoxic effect in the peripheral nervous system. Methods The left sciatic nerve of Sprague-Dawley rats (12/ group) received a single topical amitriptyline dose of 0.625, 1.25, 2.5, or 5 mg; a saline group (n = 2) was used as control. Neuropathologic evaluations were conducted in separate animals (n = 4) 1, 3, and 7 days later. Results Amitriptyline topically applied in vivo to rat sciatic nerve causes a dose-related neurotoxic effect. Drug doses of 0.625-5 mg all caused Wallerian degeneration of peripheral nerve fibers, with the number of affected fibers and the severity of the injury directly related to the dose. Conclusion Because the effective local anesthetic dose is within this dose range, the authors strongly recommend that amitriptyline not be used as a local anesthetic agent.

Loss of sympathetic nerve fibers in vital intertrochanteric bone cylinders lateral to osteonecrosis of the femoral head

2013 ◽  
Vol 80 (2) ◽  
pp. 188-194 ◽  
Author(s):  
Johannes Beckmann ◽  
Matthias Knödl ◽  
Eva Bauser ◽  
Markus Tingart ◽  
Joachim Grifka ◽  
...  
Keyword(s):  
Femoral Head ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Sympathetic Nerve Fibers
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