scholarly journals Relationship between representation and severity of Gilles de la Tourette syndrome and comorbidities

2020 ◽  
Vol LII (1) ◽  
pp. 14-18
Author(s):  
Aleksandr G. Sofronov ◽  
Dmitrij E. Zaytsev ◽  
Il’ya D. Zaytsev ◽  
Nikolaj A. Titov
Keyword(s):  
Tourette Syndrome ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Child Psychiatrist ◽  
Comorbid Disorders ◽  
Tic Disorder ◽  
Inappropriate Behaviors ◽  
Child Psychologist ◽  
Mental Comorbidities ◽  
Observation Period

Aim. To study representation and distribution of comorbidities, their relationship with clinical presentation and severity of Gilles de la Tourette syndrome, with age of onset of motor and vocal tics. Methods. Were examined 58 children (44 boys, 14 girls) at the age of 11.070.52 years (418 years old) with observation period from 1 to 10 years with diagnosis of Gilles de la Tourette syndrome. All patients were examined by child psychiatrist, neurologist, child psychologist to clarify diagnosis and psychopathological comorbidities. Comorbidities were determined by clinical-psychopathological method and by standardized scales. Results. In the course of the research there were identified the main comorbid disorders, their representation, prevalence and relationship with tic disorder. The results of the study allow us to conceptualize separately comorbid disorders and complex tic-like symptoms. According to the study, comorbid disorders tend to develop on their own, while a number of specific features tend to manifest themselves, increasing representation during the course of development of the main tic disorder. Conclusion. Such specific features as self-injurious behaviors, non-obscene, socially inappropriate behaviors, coprophenomena, echophenomena; and paliphenomend are proposed to be called complex tic-like symptoms. In our opinion, we should differentiate and separately classify complex tic-like symptoms from mental comorbidities, that have their own development regardless of the course of tics in Gilles de la Tourette syndrome.

scholarly journals Profile Of Tourette Syndrome In Children And Adolescents From A Tertiary Care Child Psychiatry Centre In India

2019 ◽  
Vol 8 (2) ◽  
pp. 45-49
Author(s):  
U. Karki ◽  
L. Sravanti ◽  
E. Sharma ◽  
P. Jacob ◽  
J.V.S. Kommu ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Tourette Syndrome ◽  
Age Of Onset ◽  
Indian Subcontinent ◽  
Tertiary Care ◽  
Retrospective Chart Review ◽  
Comorbid Condition ◽  
Tertiary Care Centre ◽  
Tic Disorder ◽  
Compulsive Disorder

Introduction: Tourette Syndrome is a type of tic disorder that is not as rare as it was once thought to be. There is a paucity of literature on Tourette syndrome in children and adolescents in the Indian setting. The objectives of this study were to elucidate sociodemographic and clinical profile of children and adolescents with Tourette syndrome. Material and Method: The present study is a retrospective chart review of children and adolescents up to age 18 years diagnosed with Tourette Syndrome in a tertiary care centre, India. This sample is from a subset of a larger sample of case records of patients with a diagnosis of tic disorder, coded as F 95, according to ICD 10 from 1st January 2014 to 31st December 2017 (4 years duration). Results: The sample included 28 children. All of them were male, and the mean age of onset was 8.2 years. The period prevalence of Tourette syndrome was 0.22%. The entire sample received pharmacotherapy and the most common medication prescribed was Risperidone followed by Clonidine, Aripiprazole, Haloperidol, and Tetrabenazine. Majority (64.28%) of the sample had a comorbid condition. The most common comorbid conditions were Hyperkinetic Disorders followed by Obsessive Compulsive Disorder Specific and Specific Developmental Disorder of Scholastic skills Conclusion: Tourette syndrome can be a disabling condition in school-going children. There is a need for population-based studies for estimating its prevalence in Indian subcontinent., and there is also a great need to increase awareness and sensitize the public to seek help to improve the quality of life of children and adolescents with Tourette syndrome.

scholarly journals Heterogeneity of the Clinical Presentation of the MEN1 LRG_509 c.781C>T (p.Leu261Phe) Variant Within a Three-Generation Family

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 512
Author(s):  
Aleksandra Gilis-Januszewska ◽  
Anna Bogusławska ◽  
Kornelia Hasse-Lazar ◽  
Beata Jurecka-Lubieniecka ◽  
Barbara Jarząb ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Malignant Tumors ◽  
Genetic Disorder ◽  
Family Members ◽  
Pancreatic Neuroendocrine Tumor ◽  
Index Patient ◽  
Generation Family

Multiple neuroendocrine neoplasia type 1 (MEN1) is a rare genetic disorder with an autosomal dominant inheritance, predisposing carriers to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localization, age of onset, and clinical aggressiveness, even between affected members within the same family. We describe a heterogenic phenotype of the MEN1 variant c.781C>T (LRG_509t1), which was previously reported only once in a family with isolated hyperparathyroidism. A heterozygous missense variant in exon 4 of the gene was identified in the sequence of the MEN1 gene, i.e., c.781C>T, leading to the amino acid change p.Leu261Phe in a three-generation family. In the screened family, 5/6 affected members had already developed hyperparathyroidism. In the index patient and two other family members, an aggressive course of pancreatic neuroendocrine tumor (insulinoma and non-functioning neuroendocrine tumors) with dissemination was diagnosed. In the index patient, late diagnosis and slow progression of the disseminated neuroendocrine tumor have been observed (24 years of follow-up). The very rare variant of MEN1, LRG_509t1 c.781C>T /p.Leu261Phe (LRG_509p1), diagnosed within a three-generation family has a heterogenic clinical presentation. Further follow-up of the family members should be carried out to confirm the spectrum and exact time of clinical presentation.

scholarly journals Comorbid chronic tic disorder and tourette syndrome in children requiring inpatient mental health treatment

2021 ◽  
pp. 135910452110079
Author(s):  
Shaheen Zinna ◽  
Rebecca Luxton ◽  
Efstathios Papachristou ◽  
Danai Dima ◽  
Marinos Kyriakopoulos
Keyword(s):  
Mental Health ◽  
Tourette Syndrome ◽  
Mental Health Treatment ◽  
Autism Spectrum ◽  
Continuous Variables ◽  
Tic Disorder ◽  
Exact Test ◽  
Compulsive Disorder ◽  
Inpatient Mental Health ◽  
Chronic Tic Disorder

Objective: Children needing admission to an inpatient mental health unit often present with severe neuropsychiatric disorders characterised by complex psychopathology. We aimed to examine all admitted children with comorbid chronic tic disorder (CTD) and Tourette syndrome (TS) over a 10-year period and determine the clinical significance of these diagnoses. Method: A retrospective, naturalistic study was conducted, comparing children with and without CTD/TS in terms of co-morbid diagnoses, medication use, access to education, aggression contributing to the admission, duration of admission, functional outcomes and satisfaction with treatment. Data were analysed using Chi-square/Fisher’s exact test and t-test for categorical and continuous variables, respectively, and subsequently with unadjusted and adjusted linear and logistic regression analyses. Results: A relatively high proportion of children had co-morbid CTD/TS (19.7%). There was a significant association with co-morbid obsessive-compulsive disorder, intellectual disability and autism spectrum disorder but not attention deficit hyperactivity disorder. CTD/TS were associated with longer admissions even after adjustments for confounding but did not seem to be independently associated with other examined clinical characteristics. Conclusions: The prevalence of CTD/TS in children needing inpatient treatment is significant. In our sample, comorbid CTD/TS seem to represent a marker of overall symptom severity as evidenced by longer admissions.

scholarly journals The prevalence of tic disorders in children and adolescents in Brazil

2014 ◽  
Vol 72 (12) ◽  
pp. 942-948 ◽  
Author(s):  
Helvio L. Alves ◽  
Elizabeth M. A. B. Quagliato
Keyword(s):  
Special Education ◽  
Children And Adolescents ◽  
Tourette Syndrome ◽  
Special Education Students ◽  
Tic Disorders ◽  
Education Students ◽  
Tic Disorder ◽  
Item Questionnaire ◽  
Chronic Tic Disorder

Tourette syndrome (TS) and tic disorders represent events of familiar magnitude characterized by involuntary movements and/or vocalization. To determine the prevalence of TS/tic disorders we studied a sample of 762 subjects (388 M, 374 F), between 1992 and 1997, age 6 to 43 years old, taken out of a population of 10,155 subjects (4,918 M, 5,237 F; age: 3-56 years old). A structured 4-item questionnaire, direct interview (multistaged), >1 yr follow-up, were used. 9,565 subjects (4,614 M, 4,951 F) sent back the questionnaires, 3,354 of these (1,671 M, 1,683 F) with positive answers to tics. 42 subjects (31 M, 11 F, age: 7-21 years old, mean: 11 years old) met the DSM-III-R criteria. The total minimal prevalence of TS is 0.43%, with a 3:1 ratio male/female. The minimal prevalence of chronic tic disorder is 2.27%. The total minimal prevalence for tic disorders at all is 2.91%. No special education students participation.

Obsessive-Compulsive Disorder With and Without Tic Disorder: A Comparative Study From India

CNS Spectrums ◽  
2008 ◽  
Vol 13 (8) ◽  
pp. 705-711 ◽  
Author(s):  
T.S. Jaisoorya ◽  
Y.C. Janardhan Reddy ◽  
S. Srinath ◽  
K. Thennarasu
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Early Age ◽  
Obsessive Compulsive ◽  
The West ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Symptom Profile ◽  
Spectrum Disorders ◽  
Motor Tics

ABSTRACTIntroduction: Evidence from phenomenological, family, genetic, and treatment studies from Western centers have suggested that tic-related obsessive-compulsive disorder (OCD) could be different from non-tic-related OCD. This study from India investigated the differences in OCD with and without tics, with respect to sociode-mographics, symptom profile, and comorbidity, including obsessive-compulsive spectrum disorders, to examine whether the clinical profile of tic-related OCD is similar to that reported previously.Methods: Fifty subjects with OCD and tics (chronic motor tics and Tourette syndrome) were compared with 141 OCD subjects without tics.Results: Subjects having OCD with tics tended to be males, and had an earlier onset of illness. They had more of symmetry/aggressive and religious obsessions, and cleaning, ordering/arranging, hoarding, and repeating compulsions and were associated with trichotillomania and hypochondraisis. Stepwise backward (Wald) regression analysis showed that an early age of onset, male gender, aggressive obsessions, cleaning compulsions, and trichotillomania were significantly associated with tic-related OCD.Conclusion: The findings of this study from India are broadly similar to those reported previously from the West indicating the universality of differences in tic- and non-tic-related OCD. Our findings also support the existing evidence that tics contribute to the heterogeneity of OCD.

scholarly journals Juvenile Ossifying Fibroma of the Maxilla: A Case Report

1970 ◽  
Vol 9 (1) ◽  
pp. 49-52
Author(s):  
NTH Syarifah ◽  
AR Roselinda ◽  
M Irfan
Keyword(s):  
Case Report ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Medical Science ◽  
Ossifying Fibroma ◽  
Local Growth ◽  
Juvenile Ossifying Fibroma

Juvenile ossifying fibroma (JOF) is an uncommon, benign, bone-forming neoplasm with aggressive local growth that is distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation and potential behaviour. We reported a 10 year old girl presenting with a growth in the left upper buccal gingiva which later was diagnosed as juvenile ossifying fibroma. The nature of the disease and outline of management were discussed. Keywords: Ossifying fibroma; Juvenile; Maxilla. DOI: 10.3329/bjms.v9i1.5231 Bangladesh Journal of Medical Science Vol.09 No.1 Jan 2010 49-52

scholarly journals Effectiveness of behaviour therapy for children and adolescents with Tourette syndrome and chronic tic disorder in a real-world setting

2020 ◽  
Author(s):  
Per Andrén ◽  
Vera Wachtmeister ◽  
Julia Franzé ◽  
Caroline Speiner ◽  
Lorena Fernández de la Cruz ◽  
...  
Keyword(s):  
Young People ◽  
Tourette Syndrome ◽  
Real World ◽  
Post Treatment ◽  
Reversal Training ◽  
Behaviour Therapy ◽  
Tic Disorder ◽  
Chronic Tic Disorder ◽  
Habit Reversal Training ◽  
Tic Severity

Background: Treatment guidelines recommend behaviour therapy (BT) as the first-line intervention for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). The efficacy of BT has been documented in randomised controlled trials (RCTs), but it is unclear to what extent these results are generalisable to real-world clinical settings, and whether the therapeutic gains are maintained long-term.Methods: In this naturalistic study, 74 young people with TS/CTD (aged 6 to 17) received BT (including psychoeducation, exposure with response prevention, habit reversal training or a combination of these treatments) at a specialist clinic in Stockholm, Sweden. Data were routinely collected at baseline, post-treatment, and at 3-, 6-, and 12-month follow-ups. Measures included the clinician-rated Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impression – Improvement scale (CGI-I), amongst others.Results: Tic severity and tic-related impairment (as measured by the YGTSS) improved significantly after treatment, with large within-group effect sizes (d=1.03 for the YGTSS Total Tic Severity Score, and d=1.37 for the YGTSS Impairment Score). At post-treatment, 57% of the participants were classified as treatment responders according to the CGI-I. Both tic severity and tic-related impairment continued to improve further through the follow-up, with 75% of the participants being rated as responders 12 months after the end of treatment. Significant improvements were also observed across a range of secondary measures.Conclusions: BT is an effective and durable treatment for young people with TS/CTD in a real-world clinical setting, with effects comparable to those reported in RCTs.

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