scholarly journals Effect of vitamin D3 (cholecalciferol) levels on the development of cognitive and psychoemotional disorders in patients with cerebrovascular disease

2020 ◽  
Vol 20 (1) ◽  
pp. 93-100
Author(s):  
Sergey V. Lobzin ◽  
Grigoriy I. Shvartsman ◽  
Evgenia M. Pervova ◽  
Inga V. Chistova ◽  
Ekaterina A. Yurkina
Keyword(s):  
Quality Of Life ◽  
Cerebrovascular Disease ◽  
Interleukin 6 ◽  
Peripheral Blood ◽  
Comparison Group ◽  
Interleukin 1 ◽  
Quality Of Life Indicators ◽  
Highly Sensitive ◽  
The Relationship

In recent years, the problem of vascular cognitive impairment is becoming increasingly important due to the increasing prevalence of cerebrovascular disease. The aim of this study was to determine the relationship between 25(OH)D, highly sensitive CRP, interleukin-1, interleukin-6 and cognitive function in patients with cerebrovascular disease and to assess their impact on quality of life. Materials and methods. 58 patients with cerebrovascular disease aged 3181 years were examined. The comparison group consisted of 24 patients, comparable in age and sex, without the studied pathology. In the study, patients were determined by the level of 25(OH)D, interleukin-1, interleukin-6, highly sensitive CRP in peripheral blood. All patients underwent neuropsychological, psychometric examination and study of their quality of life. Results. In the study, the level of 25(OH)D in patients with cerebrovascular disease was lower compared to the group without this pathology. Concentrations of interleukin-1, interleukin-6, and highly sensitive CRP in patients in the main group were statistically significantly higher than in those in the comparison group. Higher concentrations of highly sensitive CRP, interleukin-1, and interleukin-6 were found in patients with low vitamin D availability. The study obtained direct correlations between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing (MMSE, MoCA, FAB, Schulte tables (performance), the Drawing hours test) and the inverse with the degree of workability (Schulte tables). An inverse correlation of average strength was observed between the results of psychometric testing and the level of 25(OH)D in peripheral blood. The study confirmed the relationship between the level of 25(OH)D in peripheral blood and quality of life indicators, in the form of a direct correlation. Conclusion. The study found that the higher the concentration of 25 (OH)D and the lower the level of interleukin-1, interleukin-6, and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive and psychoemotional disorders. The study confirmed the relationship between the level of 25(OH)D and quality of life indicators.

The degree of severity and structure of cognitive disorders in patients with cerebrovascular disease, depending on the level of 25-hydroxycalciferol

2021 ◽  
Vol 21 (2) ◽  
pp. 53-61
Author(s):  
Gregory I. Shvartsman ◽  
Evgeniya M. Pervova ◽  
Vitaly V. Goldobin ◽  
Natalia M. Tertyshnaya
Keyword(s):  
Cerebrovascular Disease ◽  
Interleukin 6 ◽  
Peripheral Blood ◽  
Comparison Group ◽  
Neuropsychological Testing ◽  
Cognitive Disorders ◽  
Inflammatory Factors ◽  
Delayed Reproduction ◽  
Highly Sensitive ◽  
And Gender

BACKGROUND: In recent years, a significant increase in cerebrovascular pathology, which is often accompanied by cognitive deficits, has been noted all over the world. AIM: The aim of this study is to determine the severity and structure of cognitive disorders depending on the level of 25(OH)D in patients with cerebrovascular disease. MATERIALS AND METHODS: 146 patients with cerebrovascular disease aged from 30 to 80 years were examined. The comparison group consisted of 40 patients, comparable in age and gender, without the studied pathology. During the study, the level of 25(OH)D, interleukin-6, highly sensitive C-reactive protein in the peripheral blood was determined in patients and a neuropsychological examination was performed. RESULTS: In patients with cerebrovascular disease, the level of 25(OH)D it was lower in comparison with patients without this pathology. Patients with higher rates of inflammatory factors had significantly lower concentrations of 25(OH)D in the peripheral blood. The study revealed a correlation between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing: direct MMSE, MoCA, FAB and reverse Schulte tables (performance). When assessing cognitive disorders in patients with cerebrovascular disease, according to the results of neuropsychological testing, it was possible to identify significantly significant differences between the main and the comparison group according to the following scales: MMSE (p = 0.04), MoCA (p = 0.001), FAB (p = 0.007), Schulte Tables (performance) (p = 0.06), respectively. When interpreting the MMSE scale, significantly significant differences between the groups were found in the attention assessment (p = 0.03), and in the analysis of the MoCA scale in the sections delayed reproduction (p = 0.03) and conceptualization (p = 0.04), respectively. In patients with cerebrovascular disease, memory is most affected by the type of delayed reproduction failure, which was observed in 53-76% of cases in our study. CONCLUSIONS: The study found that the higher the concentration of 25(OH)D and the lower the level of interleukin-6 and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive disorders. In patients with cerebrovascular disease, memory is most affected by the type of delayed reproduction failure.

scholarly journals The relationship between four health-related quality-of-life indicators and use of mammography and Pap test screening in US women

2015 ◽  
Vol 24 (9) ◽  
pp. 2113-2128 ◽  
Author(s):  
Pranav K. Gandhi ◽  
William M. Gentry ◽  
Jeffery L. Kibert ◽  
Erica Y. Lee ◽  
Whitney Jordan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pap Test ◽  
Health Related Quality ◽  
Quality Of Life Indicators ◽  
Related Quality ◽  
Health Related ◽  
Pap Test Screening ◽  
The Relationship

scholarly journals IMPACT OF SOME FACTORS ON QUALITY OF LIFE OF ELDERLY CASES WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2020 ◽  
Vol 74 (2) ◽  
pp. 91-94
Author(s):  
S.V. Turkina ◽  
◽  
A.A. Grishchenko ◽  
N.I. Zhernakova ◽  
T.Yu. Lebedev ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Quality Of Life Indicators ◽  
Survey Results ◽  
The Relationship

40 elderly and senile patients were examined including 20 patients with exacerbation of chronic obstructive pulmonary disease (COPD) of moderate severity (experimental group) and 20 cases without COPD, acute diseases and exacerbations of chronic pathology (control group). Impact of COPD was studied for various aspects of quality of life. It was analyzed the nature and strength of the relationship between of quality of life indicators and biochemical survey results.

scholarly journals The Relationship between Social Ideas about a Healthy Lifestyle and the Level of Physical and Mental Health

2020 ◽  
pp. 19-26
Author(s):  
Olga Petrovna Krolevets
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Healthy Lifestyle ◽  
The Other ◽  
Physical And Mental Health ◽  
Quality Of Life Indicators ◽  
The One ◽  
The Relationship ◽  
Mental And Physical Health

We studied social ideas about a healthy lifestyle, features of the quality of life and neurotic states of respondents. The relationship between the completeness of ideas about a healthy lifestyle, on the one hand, and mental and physical health, on the other, is revealed. The average values of quality of life indicators for a group with an unformed idea of healthy lifestyle are lower than for a group with a formed idea of healthy lifestyle.

The relationship between optimism, personal control and quality of life of patients with COPD

2002 ◽  
Author(s):  
R. Arnold ◽  
A. V. Ranchor ◽  
N. H. T. ten Hacken ◽  
G. H. Koeter ◽  
V. Otten ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Personal Control ◽  
The Relationship

Management of Economics and State "Bottom"

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev
Keyword(s):  
Quality Of Life ◽  
Artificial Intelligence ◽  
Probabilistic Models ◽  
Human Life ◽  
Special Software ◽  
Human Quality ◽  
Relationship Of ◽  
The Relationship

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.

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