scholarly journals Organizational measures for the prevention of complications of blood transfusion

2012 ◽  
Vol 93 (2) ◽  
pp. 383-384
Author(s):  
N I Stepanova ◽  
N A Polyanin
Keyword(s):  
Blood Transfusion ◽  
Essential Element ◽  
Fresh Frozen Plasma ◽  
Blood Components ◽  
Medical Department ◽  
Transfusion Therapy ◽  
Surgical Interventions ◽  
Fresh Frozen ◽  
Passport Data ◽  
Instructions For Use

Organization of the blood transfusion therapy in a hospital is an essential element in delivering medical care to the wounded, injured and sick. In each medical department of the hospital a physician responsible for the organization of transfusion therapy is appointed by the order of the chief. The provision of donor blood and its components for the elective surgical interventions is carried out on the basis of preliminary requests of the attending physicians. It is unacceptable to conduct elective surgical interventions without the required number of screened blood components. In order to conduct blood transfusions when providing emergency care there should be a supply of fresh frozen plasma and frozen erythrocytes in the hospital in the amount of a monthly requirement. All blood transfusion must have a clear clinical rationale and should be performed in strict accordance with current instructions for use of blood components. The completed measures for determination of blood component’s compatibility with the blood of the recipient, the name, amount, passport data of each transfusion environment have to be reflected in the blood transfusion protocol.

scholarly journals DIFFERENCES IN CHANGES OF HEMOGLOBIN BETWEEN 6-12 HOURS AND 12-14 HOURS AFTER TRANSFUSION

2018 ◽  
Vol 24 (2) ◽  
pp. 108
Author(s):  
Rosita Linda ◽  
Devita Ninda
Keyword(s):  
Blood Transfusion ◽  
Secondary Data ◽  
Hemoglobin Concentration ◽  
Fresh Frozen Plasma ◽  
Blood Components ◽  
Blood Products ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Hemoglobin Measurement ◽  
Baseline Hemoglobin

Each year more than 41,000 blood donations are needed every day and 30 million blood components are transfused. Blood products that can be transfused include Packed Red Cells (PRC), Whole Blood (WB), Thrombocyte Concentrate (TC), Fresh Frozen Plasma (FFP). Monitoring Hemoglobin (Hb) after transfusion is essential for assessing the success of a transfusion. The time factor after transfusion for Hemoglobin (Hb) examination needs to be established, analyze to judge the success of a blood transfusion which is performed. The aim of this study was to analyze the differences in changes of hemoglobin between 6-12 hours, and 12-24 hours after-transfusion. This study was retrospective observational using secondary data. The subjects were patients who received PRC, and WBC transfusion. At 6-12, and 12-24 hours after-transfusion, hemoglobin, RBC, and hematocrit were measured. Then the data were analyzed by unpaired t-test. The collected data included the results of the Hb pre-transfusion, 6-12, and 12-24 hours after-transfusion. The subjects of this study were 98 people. The administration of transfusion increased by 10-30% in hemoglobin concentration at 6-12 hours after-transfusion. While at 12-24 hours after-transfusion, hemoglobin after-transfusion increased 15-37% from the baseline. Hemoglobin values were not different at any of the defined after-transfusion times (p = 0.76 (p>0.05)). Hemoglobin values were not different at 6-12 hours, and 12-24 hours after-transfusion.    Keywords: Hemoglobin, measurement, after-transfusion 

scholarly journals Distribusi Komponen Darah Thrombocyte Contentrate (TC)

2021 ◽  
Vol 2 (2) ◽  
pp. 75-81
Author(s):  
Gina Almirah ◽  
Nurpuji Mumpuni ◽  
Fransisca Romana Sri Supadmi
Keyword(s):  
Blood Transfusion ◽  
Maternity Hospital ◽  
Fresh Frozen Plasma ◽  
Buffy Coat ◽  
Red Cross ◽  
Blood Component ◽  
Distribution Data ◽  
Blood Components ◽  
Blood Transfusion Service ◽  
Fresh Frozen

Blood transfusions become an important component in the management of patients with injuries to cases of accidents, surgical conditions, violence, pregnancy complications, anemia, hemodialysis, and other medical conditions. The blood transferred can be complete blood and blood components such as Packed Red Cells (PRC), Thrombocyte Concentrate (TC), Anti hemophilia Factor (AHF)/Cryoprecipitate, Fresh Frozen Plasma (FFP), Buffy Coat (BC), Liquid Plasma (LP). This research aims to determine the distribution of blood component Thrombocyte Concentrate (TC) in Indonesian Red Cross Blood Transfusion Service Pontianak City. The design of this research is a quantitative study with a descriptive design, the approach of time used is retrospective by collecting and processing all the distribution data of blood component Thrombocyte Concentrate (TC) in Indonesian Red Cross Blood Transfusion Service Pontianak City in 2019. Processing and analyzing data in this study using the Statistical Product and Service Solutions (SPSS) application. Data analysis results of the number of Thrombocyte Concentrate requests 5,427 bags in 12 months, with an average (Mean) of 452.25 and a data spread (Std. Deviation) of 224.620 is greater than the dosage amount and the distribution of Thrombocyte Concentrate 3,444 bags in 12 months, with an average (Mean) 287 and a data spread (Std. Deviation) 79.681. The most demand and distribution is Dr. Soedarso country general hospital, while the fewest are the Nabasa maternity hospital. The distribution of Thrombocyte Concentrate blood components in Indonesian Red Cross Blood Transfusion Service Pontianak City still needs improvement for both inventory and distribution to be fulfilled the number of Thrombocyte Concentrate requests.

scholarly journals Importance of haemovigilance and reports on transfusion reaction in blood component therapy

2012 ◽  
Vol 65 (1-2) ◽  
pp. 50-53 ◽  
Author(s):  
Jasmina Grujic ◽  
Zdravko Gulan ◽  
Zorana Budakov
Keyword(s):  
Blood Transfusion ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Safe Procedure ◽  
Transfusion Reaction ◽  
Blood Components ◽  
Blood Component Therapy ◽  
Fresh Frozen ◽  
Novi Sad ◽  
Transfusion Reactions

Introduction. Application of blood and blood components throughout decades is very successful and mostly safe procedure in patients? therapy. However, it may lead to unfavourable effects, such as transfusion reactions. Material and Methods. In the period from 2000 to 2009, 180 transfusion reactions were reported at the Department of Clinical Transfusion of the Service for Blood Transfusion of Vojvodina in Novi Sad. The aetiology of transfusion reactions was determined by examining pretransfusion and post-transfusion sample of patient?s blood and by examining the unit of blood component that induced reaction. Results. Out of 180 reported transfusion reactions, 98 (54.4%) were febrile non-haemolytic transfusion reactions, 69 (38.3%) allergic reactions and 2 (1.11%) haemolytic reactions. Blood components that caused most of transfusion reactions were erythrocytes (62.4%), fresh frozen plasma (11.2%) and platelets (14.4%). All patients underwent multiple transfusions. Discussion. The fact that only 0.13% transfusion reactions were reported, compared with data from literature (2-15%), points to the lack of regular reporting of transfusion reactions, as well as the fact that there is only one report of delayed transfusion reaction. Conclusions. To improve and make blood transfusion safer it is necessary to respect all pre-transfusion procedures, constant follow up of blood transfusion must be done and patients with diagnosed non-haemolytic transfusion reaction should be given leukocyte reduced blood components.

scholarly journals STUDY OF INDICATIONS OF BLOOD COMPONENTS IN OBSTETRIC HEMORRHAGE AT A TERTIARY CARE CENTRE IN SOUTH INDIA

2020 ◽  
pp. 43-45
Author(s):  
Sushama D ◽  
Kumari K.C. Usha ◽  
Anumole Jose
Keyword(s):  
Blood Transfusion ◽  
Fresh Frozen Plasma ◽  
Uterine Atony ◽  
Red Cells ◽  
Strong Positive Correlation ◽  
Blood Components ◽  
Obstetric Hemorrhage ◽  
Common Indication ◽  
Fresh Frozen ◽  
Frozen Plasma

Blood transfusion is an essential part of management of many indications in obstetrics. A prospective study was conducted with objectives to portray the indications, mean usage and inter-relationship of blood components in obstetric hemorrhages. Out of total 10063 obstetric patients, 405 patients (N) required transfusion (4.02% incidence). Detailed clinical and transfusion history and management was recorded and analyzed. A total of 1386 units (55% packed red cells, 19% platelet concentrates, 24% fresh frozen plasma and 2% cryoprecipitate) of blood components were used to treat obstetric hemorrhage cases. Most common indication for blood transfusion was observed to be uterine atony (37%) followed by abruption (18.5%) and genital tract trauma during delivery (14.8%) and other causes. A strong positive correlation of PRC usage was observed with the number of units (usage) of PC, FFP and Cryoprecipitate units transfused to the patients with obstetric hemorrhage (P<0.00001; P<0.00001 and P=0.002786 respectively). Most common indication for transfusion of blood components was uterine atony. Maximum mean usages of packed red cells, platelet concentrate and fresh frozen plasma were for placenta accreta/percreta/increta.

The physiology of blood in anaesthetic practice

2017 ◽  
Author(s):  
Hanane El Kenz ◽  
Philippe Van der Linden
Keyword(s):  
Blood Transfusion ◽  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Blood Components ◽  
Pathogen Inactivation ◽  
Septic Complications ◽  
Packed Red Blood Cells ◽  
Blood Component Therapy ◽  
Fresh Frozen

Following the discovery of the ABO blood groups by Landsteiner in 1901, Albert Hustin described the first transfusion of a whole blood unit in 1914. The modern transfusion era really begins in 1916 with the discovery of sodium citrate as an anticoagulant by the same physician, allowing blood conservation in dedicated packs. Since that time, many advances have been made especially over the past two decades in the storage, the conservation, and the laboratory testing of blood components and in transfusion medicine practice. Transfusion of whole blood has been replaced by blood component therapy, which consists of the administration of packed red blood cells, fresh frozen plasma, or platelets. Although blood transfusion is safer than ever, the risk of complications will never reach zero. The risk of infectious transfusion-transmitted diseases has been markedly reduced by the implementation of extensive infectious disease testing, donor selection, and pathogen-inactivation procedures. In countries with a high human development index, the leading causes of allogeneic blood transfusion-related deaths actually resulted from immunological and septic complications. The first section of this chapter describes the structure, function, and immunological aspects of the different blood components that are routinely transfused today. The second section details the composition of the different blood components, their indications, the pre-transfusion compatibility tests, and the main adverse effects associated with their transfusion.

scholarly journals The usage of blood components in obstetrics

Medicina ◽  
2010 ◽  
Vol 46 (8) ◽  
pp. 561 ◽  
Author(s):  
Dalia Adukauskienė ◽  
Audronė Veikutienė ◽  
Agnė Adukauskaitė ◽  
Vincentas Veikutis ◽  
Kęstutis Rimaitis
Keyword(s):  
Blood Transfusion ◽  
Fresh Frozen Plasma ◽  
Massive Bleeding ◽  
Therapeutic Options ◽  
Blood Components ◽  
Blood Products ◽  
Obstetric Hemorrhage ◽  
Risk Of Death ◽  
Obstetric Emergencies ◽  
Fresh Frozen

Major obstetric hemorrhage remains the leading cause of maternal morbidity and mortality worldwide. Even though blood transfusion may be a life-saving procedure, an inappropriate usage of blood products in obstetric emergencies especially in cases of massive bleeding is associated with increased morbidity and risk of death. Thorough knowledge of the etiology, pathophysiology, and optimal therapeutic options of major obstetric hemorrhage may help to avoid lethal outcomes. There are evidence-based data about some risks related with transfusion of blood components: acute or delayed hemolytic, febrile, allergic reactions, transfusion-related acute lung injury, negative immunomodulative effect, transmission of infectious diseases, dissemination of cancer. This is why the indications for allogeneic blood transfusion are restricted, and new safer methods are being discovered to decrease the requirement for it. Red cell alloimmunization may develop in pregnancy; therefore, all pregnant women should pass screening for irregular antibodies. Antierythrocytic irregular antibodies may occur due to previous pregnancies or allogeneic red blood cell transfusions, and it is important for blood cross-matching in the future. Under certain circumstances, such as complicated maternal history, severe coagulation abnormalities, severe anemia, the preparation of cross-matched blood is necessary. There is evidence of very significant variation in the use of blood products (red cells, platelets, fresh frozen plasma, or cryoprecipitate) among clinicians in various medical institutions, and sometimes indications for transfusion are not correctly motivated. The transfusion of each single blood product must be performed only in case of evaluation of expected effect. The need for blood products and for their combination is necessary to estimate for each patient individually in case of obstetric emergencies either. Indications for transfusion of blood components in obstetrics are presented in order to improve the skills of doctors and to optimize therapeutic options in obstetric emergencies.

Factors Affecting Transfusion of Fresh Frozen Plasma, Platelets, and Red Blood Cells During Elective Coronary Artery Bypass Graft Surgery

2003 ◽  
Vol 127 (4) ◽  
pp. 415-423
Author(s):  
Randal Covin ◽  
Maureen O'Brien ◽  
Gary Grunwald ◽  
Bradley Brimhall ◽  
Gulshan Sethi ◽  
...  
Keyword(s):  
Blood Cells ◽  
Prediction Models ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Artery Bypass Graft ◽  
Blood Components ◽  
Fresh Frozen ◽  
Frozen Plasma

Abstract Context.—The ability to predict the use of blood components during surgery will improve the blood bank's ability to provide efficient service. Objective.—Develop prediction models using preoperative risk factors to assess blood component usage during elective coronary artery bypass graft surgery (CABG). Design.—Eighty-three preoperative, multidimensional risk variables were evaluated for patients undergoing elective CABG-only surgery. Main Outcome Measures.—The study endpoints included transfusion of fresh frozen plasma (FFP), platelets, and red blood cells (RBC). Multivariate logistic regression models were built to assess the predictors related to each of these endpoints. Setting.—Department of Veterans Affairs (VA) health care system. Patients.—Records for 3034 patients undergoing elective CABG-only procedures; 1033 patients received a blood component transfusion during CABG. Results.—Previous heart surgery and decreased ejection fraction were significant predictors of transfusion for all blood components. Platelet count was predictive of platelet transfusion and FFP utilization. Baseline hemoglobin was a predictive factor for more than 2 units of RBC. Some significant hospital variation was noted beyond that predicted by patient risk factors alone. Conclusions.—Prediction models based on preoperative variables may facilitate blood component management for patients undergoing elective CABG. Algorithms are available to predict transfusion resources to assist blood banks in improving responsiveness to clinical needs. Predictors for use of each blood component may be identified prior to elective CABG for VA patients.

The bleeding patient

2020 ◽  
pp. 403-428
Author(s):  
Anne Craig ◽  
Anthea Hatfield
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Disseminated Intravascular Coagulation ◽  
Oxygen Supply ◽  
Fresh Frozen Plasma ◽  
Blood Transfusions ◽  
Massive Blood Transfusion ◽  
Intravascular Coagulation ◽  
Fresh Frozen ◽  
Frozen Plasma

Part one of this chapter tells you about the physiology of blood and oxygen supply, about anaemia and tissue hypoxia, and the physiology of coagulation. Drugs that interfere with clotting are discussed. Bleeding, coagulation, and platelet disorders are covered as well as disseminated intravascular coagulation. Part two is concerned with bleeding in the recovery room: how to cope with rapid blood loss, managing ongoing blood loss, and how to use clotting profiles to guide treatment. There is also a section covering blood transfusion, blood groups and typing. Massive blood transfusion is clearly described, there are guidelines about when to use fresh frozen plasma, when to use platelets, and when to use cryoprecipitate. The final section of the chapter is about problems with blood transfusions.

Transfusion of blood products

2016 ◽  
Author(s):  
Alison Smith
Keyword(s):  
Blood Transfusion ◽  
Carrying Capacity ◽  
Blood Cells ◽  
Fresh Frozen Plasma ◽  
Major Haemorrhage ◽  
Blood Products ◽  
Unlimited Supply ◽  
Fresh Frozen ◽  
Oxygen Carrying Capacity ◽  
Frozen Plasma

The transfusion of blood products may be required in the pre- and post-operative periods. However, there are inherent risks associated with blood transfusion, and there is not an unlimited supply of blood donations available. When a patient is anaemic, red blood cells should be transfused to maintain the oxygen-carrying capacity of blood. Blood products, such as platelets and fresh frozen plasma, are transfused to correct a coagulopathy and during major haemorrhage. This chapter reviews the physiology of blood, including ABO compatibility and rhesus status, the main blood products available for transfusion, and transfusion policy, including the treatment of major haemorrhage and the refusal of blood products.

scholarly journals EVALUATION OF FUNCTIONING AND STATUS OF IMPLEMENTATION OF HEMOVIGILANCE PROGRAM OF INDIA IN THE BLOOD BANKS OF SOUTHERN KERALA

2018 ◽  
Vol 11 (2) ◽  
pp. 143
Author(s):  
Sreekumar Pk ◽  
Pramod Kumar Tm ◽  
Partha Sarathi G ◽  
Debasish Gupta ◽  
Pallavi Prakash
Keyword(s):  
Training Programs ◽  
Fresh Frozen Plasma ◽  
Blood Components ◽  
Blood Banks ◽  
Fresh Frozen ◽  
Awareness Programs ◽  
Pro Forma ◽  
Survey Approach ◽  
And Training ◽  
Frozen Plasma

 Objective: The objective of this study is to evaluate the functioning and status of implementation of hemovigilance program of India (HvPI) in the blood banks of southern Kerala.Methods: It was a survey approach to analyze the facilities, working nature, and status of implementation of hemovigilance program by the blood banks located in the three districts of southern Kerala. Both goevrnment and private sector blood banks were subjected to the survey. Standard pro forma was used to collect the data. Collected data were analyzed by percentages and ratios.Results: A total of 40 blood banks were covered in the study. All the blood banks were licensed for handling whole blood. 23 blood banks were licensed for handling blood components. 6 blood banks process 100% blood into components. Majority of blood banks have excellent demand for components. Packed red cells, platelet concentrate, and fresh frozen plasma were the significant components among the prepared components. Majority of the blood banks under the survey had hospital transfusion committee (HTC). 25 blood banks replied as the HvPI is an excellent/good system. However, only 11 blood banks were enrolled in the HvPI. Training programs for the resident doctors and nurses regarding with adverse transfusion reaction and their reporting were not conducted by 17 blood banks.Conclusion: Except very few blood banks, all are need more awareness and training programs. Attention should be given in the area such as underreporting, poor implementation of hemovigilance, only serious reactions reporting, and avoiding minor reactions. Core factor is proper functioning of HTC and awareness programs about hemovigilance system.

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