scholarly journals Anemia of chronic disease in patients with HIV infection: clinical and laboratory characteristics

2014 ◽  
Vol 95 (5) ◽  
pp. 769-775 ◽  
Author(s):  
G R Hasanova ◽  
I G Mustafin
Keyword(s):  
Chronic Disease ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
C Reactive Protein ◽  
Anemia Of Chronic Disease ◽  
Reactive Protein ◽  
Iron Binding Capacity

Aim. To provide clinical and laboratory characteristics of anemia of chronic disease in HIV infection in order to improve its diagnosis. Methods. The study included 63 HIV-infected patients with anemia of chronic disease. Assessed were the frequency of complaints and physical changes, erythrocyte indices, serum iron level, total iron-binding capacity of the blood, soluble transferrin receptor and erythropoietin markers of inflammation (ferritin, interleukin-1β, tumor necrosis factor-α, soluble receptor CD14, C-reactive protein). Comparison group consisted of a group of 35 patients with iron deficiency anemia. Results. The most frequent were complaints of weakness, fatigue and diarrhea. Hemoglobin level of the majority of patients corresponded to mild anemia. It often had a micro- or normocytic character (48.1±6.8 and 46.3±6.8% of patients, respectively), was normochromic (53.7±6.8% of patients) and hyporegenerative; in 94% of patients relative level of reticulocytes in the blood level was 0.2-1.2%; 87.3% had a reduced number of red blood cells. A negative relationship between levels of hemoglobin with erythropoietin (r=-0.5, p=0.0003) was established. Low levels of serum iron was typical for anemia of a chronic disease, as well as for iron-deficiency anemia. In patients with anemia of chronic disease revealed were significantly higher levels of soluble receptor CD14, C-reactive protein and ferritin and the relatively low level of total iron binding capacity of serum. Conclusion. Anemia of chronic disease in HIV infection is characterized by a predominance of light forms, the frequent lack of «typical for anemia» complaints; mainly micro or normocytic, normochromic types of process with low serum iron; hyporegeneration character against the backdrop of an adequate response to erythropoietin-synthesizing cells decrease in hemoglobin concentration; high levels of markers of inflammation (sCD14, C-reactive protein and ferritin) and relatively low total iron binding capacity of serum.

scholarly journals The importance of iron metabolism, hepcidine and soluble transferrin receptor in pathogenesis of anemia in patients with solid tumors

2018 ◽  
Vol 20 (3) ◽  
pp. 91-94
Author(s):  
A V Gordienko ◽  
V T Sakhin ◽  
E V Kryukov ◽  
A V Sotnikov ◽  
O A Rukavitsyn
Keyword(s):  
Transferrin Receptor ◽  
Binding Capacity ◽  
Total Iron ◽  
Malignant Neoplasms ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Soluble Transferrin Receptor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Iron Binding Capacity

A comparative analysis of hemogram parameters, iron metabolism, C-reactive protein, hepcidin, soluble transferrin receptor in patients with malignant neoplasms, accompanied by anaemia and without it. Patients with anaemia compared with non-anaemic patients had lower haemoglobin, erythrocyte, hematocrit, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration, iron, iron transferrin saturation, total iron-binding capacity, and higher levels C-reactive protein, hepcidin, soluble transferrin receptor (p0,05). Negative correlations of moderate strength between hepcidin and erythrocyte levels (r=-0,41), hemoglobin (r=-0,3), hematocrit (r=-0,35), and total iron-binding capacity (r=-0,51) and transferrin (r=-0,54). In addition, negative correlations of moderate strength were revealed between the soluble transferrin receptor and hemoglobin level (r=-0,57), hematocrit (r -0,49), iron transferrin saturation (r=-0,47), mean corpuscular hemoglobin (r=-0,44), mean corpuscular volume (r=-0,39). A direct correlation of moderate strength was found between the soluble transferrin receptor and transferrin (r=0,41) and total iron-binding capacity (r=0,38), as well as between hepcidin and ferritin (r=0,61), C-reactive protein (r=0,48). In general, the development of functional iron deficiency in patients with anaemia and malignant neoplasms has been established, and the value of hepcidin and soluble transferrin receptor in the genesis of this anaemia has been confirmed.

Changes in Serum Ferritin and other ‘Acute Phase’ Proteins following Major Surgery

1984 ◽  
Vol 21 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Caroline Rubin ◽  
P J Wood ◽  
T Archer ◽  
D J F Rowe
Keyword(s):  
Serum Ferritin ◽  
Binding Capacity ◽  
Gastrointestinal Surgery ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Healthy Women ◽  
Iron Binding Capacity

We have measured ferritin concentrations in healthy women, and ferritin, C-reactive protein, iron and total iron-binding capacity in patients undergoing hysterectomy or major gastrointestinal surgery. Pre-operative serum ferritin concentrations in patients awaiting hysterectomy were significantly lower than those for patients awaiting gastrointestinal surgery and also lower than those for healthy women of similar age. Healthy women aged between 51 and 60 years had significantly higher ferritin levels than women aged 35–50 years. All patients studied showed large increases in serum ferritin and C-reactive protein concentrations after surgery and approximately similar decreases in iron and in total iron-binding capacity.

Serum hepcidin: reference ranges and biochemical correlates in the general population

Blood ◽  
2011 ◽  
Vol 117 (25) ◽  
pp. e218-e225 ◽  
Author(s):  
Tessel E. Galesloot ◽  
Sita H. Vermeulen ◽  
Anneke J. Geurts-Moespot ◽  
Siem M. Klaver ◽  
Joyce J. Kroot ◽  
...  
Keyword(s):  
Binding Capacity ◽  
Total Iron ◽  
Reference Ranges ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Hepcidin ◽  
Iron Binding Capacity ◽  
Age And Sex

AbstractTo date, concentrations of the promising biomarker hepcidin have only been assessed in serum of relatively small series of healthy volunteers and patients. We assessed age- and sex-stratified reference ranges of serum hepcidin concentration in a selected reference set and performed regression analyses to study associations between hepcidin and (biochemical) variables in a large, well-phenotyped sample of the general population (n = 2998). All participants filled out a questionnaire on lifestyle, health status, and medical history. Serum measurements of iron parameters, liver enzyme alanine aminotransferase, creatinine and C-reactive protein were available. Serum hepcidin concentrations were lower for premenopausal than for postmenopausal women (median, 4.1nM vs 8.5nM, respectively). Hepcidin concentrations in men were constant over age (median, 7.8nM). Serum hepcidin was strongly associated with serum ferritin in men and women: β-coefficient of log-transformed variables (95% confidence interval): 0.78 (0.74-0.82) and 0.83 (0.78-0.88), respectively. Additional significant, though less strong, associations were observed for C-reactive protein and total iron binding capacity in men and for total iron binding capacity, alanine aminotransferase, and glomerular filtration rate in women. Our study provides age- and sex-specific reference ranges of serum hepcidin concentration and indicates ferritin as the primary correlate of serum hepcidin concentration.

scholarly journals Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Warqaa Khalaf ◽  
Haithem Ahmed Al-Rubaie ◽  
Sami Shihab
Keyword(s):  
Rheumatoid Arthritis ◽  
Iron Deficiency ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Anemia Of Chronic Disease ◽  
Serum Hepcidin ◽  
Iron Binding Capacity

Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most important types of anemia in rheumatoid arthritis (RA). Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis. The aim is to investigate the role of circulating hepcidin and to uncover the frequency of IDA in RA. The study included 51 patients with RA. Complete blood counts, serum iron, total iron binding capacity, ferritin, and hepcidin- 25 were assessed. ACD was found in 37.3% of patients, IDA in 11.8%, and combined (ACD/IDA) in 17.6%. Serum hepcidin was higher in ACD than in control and the other groups (P≤0.001). It was strongly and positively correlated with ferritin (P<0.001), while hemoglobin, serum iron, and total iron binding capacity were negatively correlated with hepcidin (P=0.016, 0.022 and <0.001, respectively). High serum hepcidin was significantly associated with ACD in RA. IDA alone or combined with ACD was encountered in about a third of patients.

Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency.

1981 ◽  
Vol 27 (2) ◽  
pp. 276-279 ◽  
Author(s):  
F Peter ◽  
S Wang
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Deficient ◽  
Iron Binding Capacity

Abstract Ferritin values for 250 selected sera were compared with values for iron, total iron-binding capacity (TIBC), and transferrin saturation, to assess the potential of the ferritin assay for the detection of latent iron deficiency. The specimens were grouped (50 in each group) according to their values for iron and TIBC. In Group 1 (low iron, high TIBC) the saturation and ferritin values both indicated iron deficiency in all but one. In the 100 specimens of Groups 2 (normal iron, high TIBC) and 4 (normal iron, high normal TIBC), the saturation values revealed 16 iron-deficient cases, the ferritin test 55. For Groups 3 (low iron, normal TIBC) and 5 (low iron, low TIBC), the ferritin test revealed fewer cases of iron deficiency than did the saturation values (37 cases vs 51 cases, in the 100 specimens). Evidently the ferritin test detects iron deficiency in many cases for whom the serum iron and TIBC tests are not positively indicative. The correlation of serum ferritin with iron, TIBC, and transferrin saturation in the five groups was good only in the case of specimens for which the TIBC was normal; if it was abnormal the correlation was very poor.

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