scholarly journals Eye sarcoidosis. Literature review

2012 ◽  
Vol 93 (6) ◽  
pp. 948-953 ◽  
Author(s):  
A S Tezeva ◽  
A N Samoylov
Keyword(s):  
Ciliary Body ◽  
Treatment Options ◽  
Giant Cells ◽  
Acute Stage ◽  
Secondary Glaucoma ◽  
Unknown Etiology ◽  
Review Of The Literature ◽  
Target Organs ◽  
Eye Involvement ◽  
Epithelium Cells

A review of the literature devoted to eye sarcoidosis is presented. Sarcoidosis is a systemic granulomatous disease of unknown etiology, with a pathognomonic feature of non-caseous granuloma formed mainly by epithelium cells and single Langhans giant cells. Sarcoidosis has many synonyms: Besnier-Boeck-Schaumann disease, benign Schaumann’s granulomatosis, nodular reticular disease. Primary targets of sarcoidosis are lungs, intrathoracic lymph nodes, eyes and skin. During the last years eye sarcoidosis is registered more frequently, that is probably associated with better diagnosis. The frequency of the eye involvement in patients with sarcoidosis, according to different authors, is 5-69% (3rd or 4th among all the target organs involved). The eye manifestations of sarcoidosis are multiple with the uvea most frequently affected, especially iris and ciliary body. The involvement of the back of the eye includes granulomatous uveitis, vitreitis, periphlebitis. It is worth noticing that only minor non-granulomatous precipitates can be found in the acute stage of the disease. In case of chronic inflammatory process, precipitates become granulomatous. The treatment can influence both precipitates’ size and shape. In case of termination of the inflammation, precipitates are undergoing a complete resorption or decrease in size, become pigmented of transparent («precipitate shades»). The feature of sarcoidosis is the tendency to comissure formation, the pupil is hardly dilated by medicines, leading to the secondary glaucoma. Conjunctiva, extraocular muscles, retroocular tissues, lacrimal gland can be involved, as well as the optic nerve, chiasma, leading to meningovascular infiltrates formation. When diagnosed, a complex treatment with topic, symptomatic drugs and the drugs with the systemic action is used. The search of new effective treatment options is still ongoing.

Generalized Multinucleate Cell Angiohistiocytoma

2015 ◽  
Vol 19 (3) ◽  
pp. 323-325 ◽  
Author(s):  
Jennifer A.E. Doane ◽  
Kerri Purdy ◽  
Sylvia Pasternak
Keyword(s):  
Treatment Options ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Review Of The Literature ◽  
Multinucleate Cell ◽  
Multinucleate Cells

Background There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. Objective To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA. Observations The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis. Conclusions Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.

scholarly journals Localized Erdheim-Chester disease involving the thyroid gland—a case report

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Anup Singh ◽  
Dheeraj Gautam ◽  
Poonam Gautam ◽  
Mubashshirul Haq ◽  
Aru Chhabra Handa ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Treatment Options ◽  
Giant Cells ◽  
Unknown Etiology ◽  
Elderly Male ◽  
Erdheim Chester Disease ◽  
Contrast Enhanced Ct ◽  
Erdheim Chester ◽  
Chester Disease

Abstract Background Erdheim-Chester disease (ECD) is a rare multisystemic histiocytic disorder of unknown etiology. Isolated neck involvement has not been reported in literature. Case presentation An elderly male presented to our outpatient department with neck swelling of 1-month duration. Contrast-enhanced CT scan of the neck showed a mass involving the left thyroid/perithyroidal tissue with encirclement of the common carotid artery. Tru-Cut biopsy with immunohistochemistry showed CD68+, CD1a- histiocytic infiltrates with Touton giant cells compatible with ECD. BRAFV600E mutation came out to be positive. PET-CT did not reveal involvement of any other body organs. After counseling for further treatment options, the patient chose to follow up without any active treatment. The disease has not progressed at a follow-up of 1 year. Conclusion We present a case of ECD involving the thyroid gland in isolation. Absence of other organ involvement should not deter the treating physician from considering the possibility of ECD. Immunohistochemistry and testing for BRAFV600E mutation are important from the diagnostic as well as potential therapeutic point of view.

scholarly journals Indications and outcomes of enterovesical and colovesical fistulas: systematic review of the literature and meta-analysis of prevalence

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stefano Granieri ◽  
Francesco Sessa ◽  
Alessandro Bonomi ◽  
Sissi Paleino ◽  
Federica Bruno ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Symptoms ◽  
Rare Complication ◽  
Meta Analysis ◽  
Treatment Options ◽  
Palliative Surgery ◽  
Review Of The Literature ◽  
Colovesical Fistula ◽  
Level Of Evidence ◽  
Meta Analyses

Abstract Background Entero-colovesical fistula is a rare complication of various benign and malignant diseases. The diagnosis is prominently based on clinical symptoms; imaging studies are necessary not only to confirm the presence of the fistula, but more importantly to demonstrate the extent and the nature of the fistula. There is still a lack of consensus regarding the if, when and how to repair the fistula. The aim of the study is to review the different surgical treatment options, focus on surgical indications, and explore cumulative recurrence, morbidity, and mortality rates of entero-vesical and colo-vesical fistula patients. Methods A systematic review of the literature was conducted according to PRISMA guidelines. Random effects meta-analyses of proportions were developed to assess primary and secondary endpoints. I2 statistic and Cochran’s Q test were computed to assess inter-studies’ heterogeneity. Results Twenty-two studies were included in the analysis with a total of 861 patients. Meta-analyses of proportions pointed out 5, 22.2, and 4.9% rates for recurrence, complications, and mortality respectively. A single-stage procedure was performed in 75.5% of the cases, whereas a multi-stage operation in 15.5% of patients. Palliative surgery was performed in 6.2% of the cases. In 2.3% of the cases, the surgical procedure was not specified. Simple and advanced repair of the bladder was performed in 84.3% and 15.6% of the cases respectively. Conclusions Although burdened by a non-negligible rate of complications, surgical repair of entero-colovesical fistula leads to excellent results in terms of primary healing. Our review offers opportunities for significant further research in this field. Level of Evidence Level III according to ELIS (SR/MA with up to two negative criteria).

scholarly journals Erythromelanosis Follicularis Faciei et Colli: A Case Report in a Caucasian Male and Brief Review of the Literature

2020 ◽  
Vol 12 (3) ◽  
pp. 231-235
Author(s):  
Carl Maximilian Thielmann ◽  
Wiebke Sondermann
Keyword(s):  
Case Report ◽  
Family History ◽  
Clinical Presentation ◽  
Rare Condition ◽  
Unknown Etiology ◽  
Review Of The Literature ◽  
Caucasian Male

Erythromelanosis follicularis faciei et colli, a rare condition of unknown etiology, was first described by Kitamura et al. from Japan in 1960. It is characterized by a triad consisting of well-demarcated erythema, hyperpigmentation, and follicular papules. We report the case of a 50-year-old Caucasian male, who had asymptomatic symmetrical facial lesions since the age of 42. His family history was unremarkable. Published erythromelanosis follicularis faciei et colli cases of the last 10 years are summarized in this report to demonstrate the variability and differences in the clinical presentation of this uncommon diagnosis.

Treatment options and long-term outcomes in pediatric spinal cord vascular malformations: a case report and review of the literature

2020 ◽  
Vol 36 (12) ◽  
pp. 3147-3152
Author(s):  
Helen J. Zhang ◽  
Nicole Silva ◽  
Elena Solli ◽  
Amanda C. Ayala ◽  
Luke Tomycz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Vascular Malformations ◽  
Treatment Options ◽  
Review Of The Literature ◽  
Long Term Outcomes

scholarly journals Intra-Abdominal Localisation of a Buschke-Lowenstein Tumour: Case Presentation and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
N. E. Wester ◽  
E. M. Hutten ◽  
C. Krikke ◽  
Robert A. Pol
Keyword(s):  
Interferon Therapy ◽  
Verrucous Carcinoma ◽  
Treatment Options ◽  
Condyloma Acuminata ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Advantages And Disadvantages ◽  
Literature Overview ◽  
Mucosal Surfaces ◽  
Tumour Reduction

Giant condyloma acuminatum or Buschke-Lowenstein tumour is a very rare disease which usually is located in the genital, anorectal, and perianal regions. It is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces where it is locally invasive but displays a benign cytology. We describe a case of a 24-year-old woman with persisting condyloma acuminata progressing to a large intra-abdominal Buschke-Lowenstein tumour. To our knowledge such an advanced stage has only been reported once before. The severity and extent of the tumour both determine the treatment and patient outcome. Treatment was impeded by cachexia, an immunosuppressive state after kidney transplantation and difficulties in establishing a reliable diagnose. Interferon treatment was started which initially led to tumour reduction but was complicated by an interferon-induced pancreatitis, pneumonia, and fasciitis necroticans resulting in death. We present a literature overview on the treatment options for a Buschke-Lowenstein tumour, with emphasis on interferon therapy, with all the advantages and disadvantages.

scholarly journals Sclerosing Mesenteritis: Diverse clinical presentations and dissimilar treatment options. A case series and review of the literature

2011 ◽  
Vol 4 (1) ◽  
pp. 17 ◽  
Author(s):  
Konstantinos Vlachos ◽  
Fotis Archontovasilis ◽  
Evangelos Falidas ◽  
Stavros Mathioulakis ◽  
Stefanos Konstandoudakis ◽  
...  
Keyword(s):  
Treatment Options ◽  
Case Series ◽  
Sclerosing Mesenteritis ◽  
Review Of The Literature ◽  
Clinical Presentations

Ménétrier’s disease in a patient with refractory ulcerative colitis: a clinical challenge and review of the literature

2021 ◽  
Vol 14 (10) ◽  
pp. e246137
Author(s):  
Sofia Rao ◽  
Anna Viola ◽  
Omar Ksissa ◽  
Walter Fries
Keyword(s):  
Ulcerative Colitis ◽  
Rare Disease ◽  
Treatment Options ◽  
Review Of The Literature ◽  
Protein Loss ◽  
Menetrier’S Disease ◽  
Clinical Challenge ◽  
Endoscopic Remission ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

Ménétrier’s disease (MD) is a rare disease of the stomach, characterised by hypertrophic gastric folds leading to protein loss. The association with ulcerative colitis (UC) is rare but has been reported in the literature. We report a case of a 29-year-old male affected by UC with an additional diagnosis of MD 3 years after UC diagnosis. UC was refractory to several treatment lines (thiopurines, infliximab, vedolizumab and ustekinumab), and the patient underwent colectomy. Octreotide was administered for MD normalising blood biochemistry, but it was not effective in inducing endoscopic remission of the stomach. Treatment options in patients with MD and UC are discussed.

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