scholarly journals Role of selenium in development of tumors

2012 ◽  
Vol 93 (6) ◽  
pp. 883-887 ◽  
Author(s):  
S V Nagieva
Keyword(s):  
Selenium Deficiency ◽  
Tumor Stage ◽  
Selenium Level ◽  
Serum Selenium ◽  
Environmental Objects ◽  
Reverse Relationship ◽  
The Republic ◽  
Economic Regions ◽  
Serum Selenium Level

Aim. To investigate the possible relationship between content of selenium in environmental objects (soil and foods) and prevalence of tumors in the Republic of Azerbaijan. Methods. Atomic absorption spectroscopy was used for quantitative determination of selenium in soil of some economical regions of the country and in foods of every day’s local diet that are the natural nutritional sources of selenium. Serum selenium level in patients with tumors was assessed using X-ray fluorescence spectroscopy. Results. Soil and food analysis revealed low contents of selenium in them. Difference in selenium concentrations in soils from studied economic regions and in food products farmed in these regions was discovered. The serum selenium level of patients with malignancies was 37.3 μg/l (38.6 μg/l - females, 34.3 μg/l - males). There was a reverse relationship found between selenium concentrations in soils and food of the region and prevalence of tumors, as well as with serum selenium level in patients with tumors and tumor stage and malignant potential. Conclusion. The territory of Azerbaijan Republic may be considered as the region with selenium deficiency. Our research supposes that selenium deficiency can be associated with increased prevalence of malignancies in the region.

scholarly journals Association of Initial Low Serum Selenium Level with Infectious Complications and 30-Day Mortality in Multiple Trauma Patients

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1844 ◽  
Author(s):  
Soon Bo Choi ◽  
Yun Tae Jung ◽  
Jae Gil Lee
Keyword(s):  
Multiple Trauma ◽  
Selenium Deficiency ◽  
Infectious Complications ◽  
Selenium Level ◽  
Trauma Patients ◽  
Serum Selenium ◽  
Serum Selenium Levels ◽  
Multiple Trauma Patients ◽  
Serum Selenium Level ◽  
Low Serum

Low serum selenium levels are commonly observed in critically injured multiple trauma patients. This study aimed to identify the association between initial serum selenium levels and in-hospital infectious complications in multiple trauma patients. We retrospectively reviewed multiple trauma patients admitted between January 2015 and November 2017. We selected 135 patients whose serum selenium levels were checked within 48 h of admission. Selenium deficiency was defined as a serum selenium level <70 ng/mL. Survival analyses of selenium deficiency and 30-day mortality were performed. Multivariate logistic regression analysis was performed to identify the association between initial serum selenium level and in-hospital infectious complications. Thirty-day mortality (8.3% vs. 0.0%; p = 0.018) and incidence rates of pneumonia (66.7% vs. 28.3%; p < 0.001) and infectious complications (83.3% vs. 46.5%; p < 0.001) were higher in patients with selenium deficiency than in patients without selenium deficiency. Kaplan–Meier survival cures also showed similar results (log rank test, p = 0.021). Of 135 patients, 76 (56.3%) experienced at least one infectious complication during admission. High injury severity score (ISS, odds ratio (OR) 1.065, 95% confidence interval (CI) 1.024–1.108; p = 0.002) and selenium deficiency (OR 3.995, 95% CI 1.430–11.156; p = 0.008) increased the risk of in-hospital infectious complications in multiple trauma patients. Patients with selenium deficiency showed higher 30-day mortality and higher risks of pneumonia and infectious complications.

Prognostic value of serum selenium level in cutaneous melanoma

1993 ◽  
Vol 3 (1) ◽  
pp. 47
Author(s):  
B. Dréno ◽  
C. Deffuant ◽  
P. Célérier ◽  
H. L. Boiteau ◽  
P. Litoux
Keyword(s):  
Cutaneous Melanoma ◽  
Prognostic Value ◽  
Selenium Level ◽  
Serum Selenium ◽  
Serum Selenium Level

scholarly journals Relationship Between Selenium Trace and Patient Outcome After Open-Heart Surgery

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Gohar Eslami ◽  
Roya Salehi ◽  
Hamidreza Samaee ◽  
Vallialah Habibi ◽  
Mohammad Shokrzadeh ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Heart Surgery ◽  
Acute Stress ◽  
Open Heart Surgery ◽  
Selenium Level ◽  
Serum Selenium ◽  
Open Heart ◽  
Duration Of Surgery ◽  
The Relationship ◽  
Serum Selenium Level

Background: Acute stress response to heart surgery can cause major morbidity in patients. The trace of selenium is useful for preventing heart damage. Although the trend of selenium changes is of high importance for body balance, the usefulness of routine use and effectiveness of this element for patients under open-heart surgery is still unclear. Objectives: This study aimed at assessing serum selenium level before and after open-heart surgery and the relationship between selenium trace and patient outcome. Methods: This prospective analytical study was performed on 100 patients undergoing open-heart surgery using cardiopulmonary bypass (CPB). In all patients, the serum level was measured at a predetermined time (before surgery and one and two days after surgery). Then, the relationship between serum selenium and patient outcome was assessed. Results: The mean serum selenium level in patients on admission was 72.90 ± 14.62 μg/L, one day after surgery was 71.20 ± 15.84 μg/L, and two days after surgery was 71.54 ± 15.97 μg/L. Serum selenium levels were inversely and significantly associated with age (r = -0.183; P = 0.034, 013) duration of surgery (r = -221 and P = 0.014), duration of intensive care unit stay (r = 0.204, P = 0.021), and duration of CPB (r = 0.223, P = 013). Conclusions: Based on this study’s results, a low level of selenium can affect patients’ outcomes after open-heart surgery.

scholarly journals Serum Selenium Level and 10-Year Survival after Melanoma

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 991
Author(s):  
Emilia Rogoża-Janiszewska ◽  
Karolina Malińska ◽  
Piotr Baszuk ◽  
Wojciech Marciniak ◽  
Róża Derkacz ◽  
...  
Keyword(s):  
Selenium Level ◽  
Serum Selenium ◽  
Lower Survival Rate ◽  
Treatment Regimens ◽  
Melanoma Diagnosis ◽  
Serum Selenium Levels ◽  
Melanoma Prognosis ◽  
Level I ◽  
Low Selenium ◽  
Serum Selenium Level

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.

Study of the correlation of serum selenium level with Behcet’s disease

2011 ◽  
Vol 14 (4) ◽  
pp. 375-378 ◽  
Author(s):  
Kamal ESALATMANESH ◽  
Ahmadreza JAMSHIDI ◽  
Farhad SHAHRAM ◽  
Fereydun DAVATCHI ◽  
Seyed Ali MASOUD ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Selenium Level ◽  
Serum Selenium ◽  
Behcet's Disease ◽  
Serum Selenium Level

POD-04.04: Serum selenium level and prostate cancer: case-control study

Urology ◽  
2007 ◽  
Vol 70 (3) ◽  
pp. 12
Author(s):  
G. Pourmand ◽  
A. Emamzadeh ◽  
K. Moradi ◽  
M. Taherimahmoudi ◽  
A. Mehrsai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Selenium Level ◽  
Cancer Case ◽  
Serum Selenium ◽  
Prostate Cancer Case ◽  
Serum Selenium Level ◽  
Control Study
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