scholarly journals Hepatoprotective activity of a new germanium-organic biologically active substance (medgerm) in experimental hepatitis

2013 ◽  
Vol 94 (5) ◽  
pp. 628-632 ◽  
Author(s):  
O L Tymchyshin
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant System ◽  
Active Substance ◽  
Toxic Hepatitis ◽  
Biologically Active ◽  
Male Rats ◽  
Biologically Active Substance ◽  
Drug Determination ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Aim. To study of the influence of new germanium-organic biologically active substance (medgerm) on lipid peroxidation and antioxidant system in rats with galactosamin-induced acute hepatitis. Methods. The experiments were carried out on Wistar male rats. Acute toxic hepatitis in rats was induced by intraperitoneal injection of D-galactosamine. Experimental animals were divided into 4 groups: first group (n=10) - intact animals that received 0.9% sodium chloride solution intraperitoneal injections throughout the observation period (control group); second group (n=40) - animals that received only D-galactosamine; third group (n=40) - rats that received medgerm intraperitoneal injections 7 days before and 7 days after the administration of D-galactosamine. The dose and administration regimen of medgerm were pre-defined. The fourth group (n=40) included rats that received Essentiale® N in the same mode as a comparator drug. Determination of thiobarbituric acid reactants, reduced glutathione levels in serum and liver homogenate supernatant, as well as superoxide dismutase and catalase activities were carried out in 1, 3, 5 and 7 days after the administration of liver toxins. Results. Medgerm has a significant effect on pro- and antioxidant homeostasis in acute toxic galactosamine-induced hepatitis. It effectively prevented the generation and accumulation of lipid peroxidation end products and preserved the activity of nonenzymatic and enzymatic antioxidant system parts. In animals treated with medgerm, studied parameters restored to reach the baseline level faster than in rats with galactosamine-induced hepatitis that were not treated with medgerm. Conclusion. The findings suggest that medgerm has the antioxidant activity and a membrane-mediated action in acute toxic hepatitis.

scholarly journals EVALUATION OF ANTIOXIDANT PROPERTIES OF MEDGERM IN ACUTE SIMULATED HEPATITIS

2020 ◽  
Vol 20 (1) ◽  
pp. 59-66
Author(s):  
O. L. Tymchishin ◽  
V.V. Godovan ◽  
N.V. Kresyun
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant System ◽  
Liver Tissue ◽  
Toxic Hepatitis ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Group I ◽  
Acute Toxic Hepatitis ◽  
Main Components ◽  
Acute Toxic

Disruption in redox processes plays a significant role in the pathogenesis of hepatitis. A balance between peroxidation, on the one hand, and the antioxidant system, on the other, is a prerequisite for maintaining normal cell activity. The modern arsenal of effective hepatoprotective drugs is not so wide therefore, the development of new hepatoprotectors is one of the topical issues in pharmacology. The purpose of the work is study the antioxidant properties of medgerma in acute experimental hepatitis. Material and methods. The experiments were performed on male rats weighing 180-220 g. Acute toxic hepatitis in rats was induced by intraperitoneal administration of D-galactosamine in a dosage of 400 mg / kg (LD50). The experimental animals were divided into 4 groups: group I (n = 10) included intact animals that were injected 0.9% sodium chloride solution (control group) intraperitoneally, II group (n = 40) involved the animals receiving only D-galactosamine; group III (n = 40) included rats, which received were administered Medmerg intraperitoneally in a dose of 0.4 mg / kg 7 days before D-galactosamine administration and 7 days after D-galactosamine administration. Group IV (n = 40) included rats, which received the comparison medicine, Essentiale® N, in at a dosage of 5 mg / kg in the same mode. The assessment of lipid peroxidation indices and the antioxidant system indices were carried out on days 1, 3, and 7 after the administration of hepatotoxin in the blood serum and the liver tissue homogenate supernatant. The condition of lipid peroxidation processes in the animals with galactosamine hepatitis was assessed by the content of lipid peroxidation end products in the blood and liver tissue that react with 2-thiobarbituric acid (TBA reactants). The condition of the main components of the antioxidant system was evaluated by the level of reduced glutathione and by the activity of catalase and superoxide dismutase. Results and discussion. It has been established that medgerm enhances the liver resistance to hepatotoxicant, as evidenced by a decrease in the level of lipid peroxidation products and the consumption of main components of the antioxidant system on the first day of hepatitis. Moreover, in the rats, which received Medgerm according to prevention scheme under acute toxic hepatitis, the course of the disease was milder than in the animals that did not receive this therapy. Conclusions and prospects for further research. Medgerm possesses hepatoprotective properties, which underlay positive effects on the state of lipid peroxidation and the main components of the antioxidant system.

The effect of the drug "Hepaton" on the reaction of lipid peroxidation

2020 ◽  
Vol 2 ◽  
pp. 112-115
Author(s):  
V.S. Ponamarev ◽  
◽  
O.S. Popova ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Body Weight ◽  
Toxic Hepatitis ◽  
Antioxidant Properties ◽  
The Body ◽  
Intragastric Administration ◽  
Bile Formation ◽  
Laboratory Rats ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

The composition of the drug "Hepaton" includes many bioactive compounds that provide the antioxidant properties of the drug, manifested by the neutralization of reactive oxygen species (ROS) with the breakaway chain free radical reactions. The aim of the study was to determine the effect of the Hepaton preparation on lipid peroxidation reactions in laboratory rats. Evaluation of the antioxidant effect of the drug was carried out on twenty laboratory rats of both sexes with a body weight of 180-220 g, divided into 2 groups. Acute toxic hepatitis in rats was induced by a single intragastric administration of 1.0 ml of a dichloroethane solution. At the same time, rats of the experimental group (n = 10) 1 hour before the introduction of di-chloroethane were injected with a solution of the drug “Hepaton” in the amount of 10 ml / kg body weight and then 1 time per day for 21 days after the use of toxicants [1]. On the 21st day after the administration of toxicants, a blood was drawn for a biochemi-cal study, which took into account the pa-rameters of the antioxidant system (diene conjugates (DC), ketodienes (CD) and malondialdehyde (MDA), as well as the level of endogenous intoxication (according to the content of MSM). Based on the results obtained, it can be con-cluded that the use of “Hepaton” in modeling acute toxic hepatitis made it possible to re-store the disturbed homeostasis of the labora-tory animal organism, the structure and in-tegrity of the hepatocyte membranes, inhibit lipid peroxidation as one of the links in the pathogenesis of hepatitis, stimulate antioxi-dant defense and power the endogenous anti-oxidant system of the body, bile formation and biliary excretion, as well as activate the reparative processes of the liver tissue at the cellular and intracellular levels.

scholarly journals Pharmacological Correction of Experimental Acute Toxic Hepatitis

2019 ◽  
Vol 8 (1) ◽  
pp. 49-54 ◽  
Author(s):  
R. G. Myazin ◽  
G. L. Snigur ◽  
D. N. Emel'yanov ◽  
M. V. Chernyshova
Keyword(s):  
Sodium Hypochlorite ◽  
Allyl Alcohol ◽  
Toxic Hepatitis ◽  
Fatty Degeneration ◽  
Male Rats ◽  
Experimental Simulation ◽  
Hepatic Tissue ◽  
Acute Toxic Hepatitis ◽  
Pharmacological Correction ◽  
Acute Toxic

The aim of study was to develop new methods of treatment of acute toxic hepatitis. To achieve this objective, the authors investigated dynamics of pathological changes in the hepatic tissue under acute intoxication followed by the pharmacological correction with sodium hypochlorite.Material and methods. The study included 45 male rats that were subjected to the experimental simulation of acute toxic hepatosis. Group 1 included intact animals; group 2 included animals that were intragastrically administered allyl alcohol resulting in acute toxic hepatosis; group 3 included rats with acute toxic hepatosis caused by allyl alcohol introduction that was corrected by sodium hypochlorite; group 4 included animals with acute toxic hepatosis corrected by essentiale N; group 5 included animals with acute toxic hepatosis corrected by the combined application of sodium hypochlorite and essentiale N. On the 6th day the animals were removed from the experiment with the followed histological examination of the hepatic tissue.Results. The introduction of allyl alcohol was accompanied by significant changes in hepatocytes expressed by dystrophic, necrotic processes and circulatory disorders of the hepatic lobules. Pharmacological correction by sodium hypochlorite, essential H, or their combination did not result in the complete histological recovery of hepatocytes; however, the degree of fatty degeneration decreased significantly under the influence of sodium hypochlorite or its combination with essentiale N.Conclusions. The application of sodium hypochlorite as a monotherapy or in combination with essential N in acute toxic hepatitis has allowed to relieve the severity of fatty liver disease. 0.03% solution of sodium hypochlorite can be effective as both - an independent method for treating acute toxic hepatitis, and in combination with other hepatoprotectors.

Action of sodium aurothiomalate in acute toxic hepatitis

1977 ◽  
Vol 83 (5) ◽  
pp. 637-640
Author(s):  
T. A. Korolenko ◽  
V. A. Shkurupii ◽  
V. M. Subbotin ◽  
G. S. Yakobson
Keyword(s):  
Toxic Hepatitis ◽  
Sodium Aurothiomalate ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Acute Toxic Hepatitis Induced by Herbal Medicine in Assam: A Pilot Study

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S567 ◽  
Author(s):  
Bhabadev Goswami ◽  
Preeti Sharma ◽  
Snigdha Saikia ◽  
Prajjalendra Barooah ◽  
Mallika Bhattacharyya ◽  
...  
Keyword(s):  
Pilot Study ◽  
Herbal Medicine ◽  
Toxic Hepatitis ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

scholarly journals Acute Hepatitis after Ingestion of a Preparation of Chinese Skullcap and Black Catechu for Joint Pain

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Charilaos Papafragkakis ◽  
Mel A. Ona ◽  
Madhavi Reddy ◽  
Sury Anand
Keyword(s):  
Side Effects ◽  
Acute Hepatitis ◽  
Joint Pain ◽  
Toxic Hepatitis ◽  
Herbal Preparations ◽  
Wide Range ◽  
Herbal Medications ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Many herbal preparations are routinely used and have been occasionally associated with a wide range of side effects, from mild to severe. Chinese skullcap and black catechu are herbal medications commonly used for their hepatoprotective and other properties. We report a case of acute toxic hepatitis associated with ingestion of Chinese skullcap and black catechu in one preparation for the alleviation of joint pain.

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