scholarly journals Laser doppler flowmetry for human blood microcirculation assessment

2014 ◽  
Vol 95 (1) ◽  
pp. 63-69 ◽  
Author(s):  
I V Barhatov
Keyword(s):  
Blood Flow ◽  
Frequency Analysis ◽  
Laser Doppler Flowmetry ◽  
Maximum Amplitude ◽  
Blood Perfusion ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Functional Changes ◽  
Microcirculatory Disorders ◽  
The Impact

The prevention and treatment of various microcirculation disorders are one of the most important problems of medical practice. The difficulties of studying the microcirculation are related to the blood vessels small size and extensive branching within organ tissues. At present, various methods of microcirculation assessment using the laser Doppler flowmetry are applied in active clinical practice in our country. The review covers the main methods of laser Doppler flowmetry used for the diagnosis of various microcirculation disorders. The method is based on the determination of tissue blood perfusion by measuring the Doppler frequency shift while tissue is illuminated by a laser beam, followed by the registration of the reflected radiation from moving and stationary tissue components. Microcirculatory oscillation rhythm plays an important role, especially in early diagnosis of many diseases. The loss of certain types of oscillations at laser Doppler flowmetry is interpreted as «spectral narrowing» and serves as a diagnostic criterion for microcirculation deregulation, which is directly related to decreased blood perfusion and tissue hypotrophy. The use of amplitude-frequency analysis of blood flow oscillations can non-invasively evaluate the impact of the various components of microvascular tone, allowing to calculate an index of neurogenic and myogenic tone and bypass index. The amplitude-frequency analysis of the laser Doppler flowmetry spectrum uses normalized parameters determining the maximum amplitude of the blood flow oscillation in different bands, as well as their ratio - microcirculation effectiveness index. Hyperemic, spastic, spastic-atonic, structural and degenerative, congestive and stasic forms of various microcirculation disorders are marked out. Each of these microcirculatory disorders is characterized by a certain ratio of structural and functional changes and changes in blood velocity, as well as impaired barrier function. The main principles of the microcirculatory disorders are described.

scholarly journals Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 436
Author(s):  
Andrey A. Fedorovich ◽  
Yulia I. Loktionova ◽  
Elena V. Zharkikh ◽  
Maria A. Mikhailova ◽  
Julia A. Popova ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Body Position ◽  
Blood Perfusion ◽  
The Body ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Postural Changes ◽  
Skin Blood Perfusion ◽  
The Right

In this study we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusion and the regulatory mechanisms of blood microcirculation in the areas of interest, and evaluate the possible significance of those effects for the diagnostics based on blood perfusion monitoring. The study involved 10 conditionally healthy volunteers (44 ± 12 years). Wearable laser Doppler flowmetry monitors were fixed at six points on the body: two devices were fixed on the forehead, on the brow; two were on the distal thirds of the right and left forearms; and two were on the distal thirds of the right and left lower legs. The protocol was used to record three body positions on the tilt table for orthostatic test for each volunteer in the following sequence: (a) supine body position; (b) upright body position (+75°); (c) tilted with the feet elevated above the head and the inclination of body axis of 15° (−15°, Trendelenburg position). Skin blood perfusion was recorded for 10 min in each body position, followed by the amplitude–frequency analysis of the registered signals using wavelet decomposition. The measurements were supplemented with the blood pressure and heart rate for every body position analysed. The results identified a statistically significant transformation in microcirculation parameters of the average level of skin blood perfusion and oscillations of amplitudes of neurogenic, myogenic and cardiac sensors caused by the postural changes. In paper, we present the analysis of microcirculation in the skin of the forehead, which for the first time was carried out in various positions of the body. The area is supplied by the internal carotid artery system and can be of particular interest for evaluation of the sufficiency of blood supply for the brain.

State of some indices of laser doppler flowmetry in norm and in gingivitis in children

1999 ◽  
Vol 80 (4) ◽  
pp. 287-290
Author(s):  
M. Z. Mirgazizov ◽  
N. K. Khamitova ◽  
E. V. Mamaeva
Keyword(s):  
Blood Flow ◽  
Early Diagnosis ◽  
Laser Doppler Flowmetry ◽  
Capillary Blood ◽  
Laser Doppler ◽  
Capillary Blood Flow ◽  
Doppler Flowmetry ◽  
Microcirculatory Disorders

Capillary blood flow of paradont tissue in norm and in children sufferred from chronic generalized gingivitis and paradontosis in slight form is studied. The method of estimating microcirculatory disorders in paradont tissue using laser doppler fluorometry is developed. The prospects of its wide use in stomatology for early diagnosis of disorders of paradont capillary net-work are stressed.

scholarly journals Diagnostics of Microcirculatory Disorders in Children with Infectious Pathology

2012 ◽  
pp. 86-88
Author(s):  
O. V. Grachieva ◽  
G. A. Kharchenko ◽  
D. N. Rasskazov ◽  
R. A. Sadretdinov
Keyword(s):  
Survey Data ◽  
Frequency Analysis ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Healthy Controls ◽  
Doppler Flowmetry ◽  
Enteroviral Infection ◽  
Peripheral Microcirculation ◽  
Microcirculatory Disorders

Laser Doppler flowmetry method (LDF) was used to examine children (43 patients with enteroviral infection, 34 patients with Astrakhan rickettsial fever, and 40 healthy controls). In addition, in view of LDF survey data, carried out was thermal assay and amplitude-frequency analysis of peripheral microcirculation predictors. Detected were incipient changes in microvasculature relative to microangiopathy.

Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

2019 ◽  
Vol 24 (2) ◽  
pp. 108-119 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

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