scholarly journals Experience of using autovaccinotherapy in dermatology

1929 ◽  
Vol 25 (7-8) ◽  
pp. 816-822
Author(s):  
N. N. Yasnitsky ◽  
А. I. Dmitriev
Keyword(s):  
Skin Diseases ◽  
Disease Process ◽  
Large Group ◽  
Therapeutic Measures

Treatment of a large group of skin diseases developing as a result of infection of the skin and its accessory formations with pyogenic microorganisms has always been a thankless and difficult task in dermatology. The diversity and unequal virulence of the flora, sometimes deep localization of the disease process, different intensity of inflammatory phenomena - all this greatly complicates the choice of appropriate therapeutic measures.

scholarly journals Manifestasi Penyakit Kulit pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Dr. Pirngadi Medan

2021 ◽  
Vol 6 (2) ◽  
pp. 65-67
Author(s):  
Dione Larissa Simanjuntak
Keyword(s):  
Diabetes Mellitus ◽  
Skin Diseases ◽  
Disease Process ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Diabetic Ulcer ◽  
Skin Manifestations ◽  
Chronic Hyperglycemia ◽  
Steven Johnson Syndrome

Background: Diabetes mellitus (DM) is a metabolic group with characteristic hyperglycemia that occurs due toabnormal insulin secretion, insulin action, or both. DM is often called the silent killer because the patients knowthey has DM only after the patient experiencing complications and manifestations. It is estimated that 30-70% of DM patients experience skin manifestations during the disease process. The relationship between the appearance of skin manifestations with diabetes mellitus is not yet known, but it is suspected due to chronic hyperglycemia and abnormalities of the immune system.Objective: To determine skin diseases in patients with type 2 diabetes at General Hospital Dr. Pirngadi Medan.Methods: This research was a descriptive study with a cross-sectional study design conducted at Dr. GeneralHospital Pirngadi Medan. Data collection was carried out through 29 medical records of patients with diabetesmellitus from January 2018 to December 2018. Samples were selected by total sampling.Results: From 29 samples studied, there were six types of skin manifestations. The most common skinmanifestations are Diabetic Ulcer (62.07%), followed by Steven Johnson Syndrome and diabetic gangrene, which both are equally 13.80%. The other skin manifestations are herpes zoster, gluteal abscess, and bullous pemphigoid (3.44%).Conclusion: The most common manifestation of the skin in patients with type 2 DM is Diabetic Ulcer.

Antipruritic therapy issues on background of skin xerosis

2021 ◽  
pp. 37-41
Author(s):  
L. S. Kruglova ◽  
E. V. Tipaeva
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Practice ◽  
Drug Therapy ◽  
Skin Diseases ◽  
Transepidermal Water Loss ◽  
Topical Drugs ◽  
Antipruritic Therapy ◽  
Therapeutic Measures ◽  
Relationship Of ◽  
The Relationship

The relationship of xerosis with various skin diseases is very multifaceted, at the same time, xerosis can be the cause of the onset or aggravation of itching. Modern recommendations for the external treatment of chronic dermatoses, accompanied by xerosis and itching, imply two directions: direct therapeutic measures during an exacerbation and the use of dermatocosmetics adapted to certain symptoms.Material and methods. We observed 26 patients (mean age 38.7 ± 1.9 years with atopic dermatitis, eczema, psoriasis or pruritus, where xerosis was present in the clinical picture and pruritus was noted. All patients used topical drugs in accordance with the nosology, in as an adjuvant therapy – Neotanin Comfort Plus cream.Research results. In atopic dermatitis, the corneometry index increased by an average of 21%, with eczema – by 20%, with psoriasis – by 22%, with skin itching – by 12%. Transepidermal water loss decreased in atopic dermatitis by 19.8%, with eczema – by 22.8%, with psoriasis – by 21.8%, with pruritus – by 18.4% The value of the total BRS index decreased by more than two times.Conclusion. The use of Neotanin Comfort Plus cream in combination with topical drug therapy (GCS, multicomponent drugs) is highly effective and safe in patients with atopic dermatitis, eczema, psoriasis or pruritus, which makes it possible to recommend it for use in wide clinical practice.

scholarly journals Bacterial pathogenesis and mediators in apical periodontitis

2007 ◽  
Vol 18 (4) ◽  
pp. 267-280 ◽  
Author(s):  
José F. Siqueira Jr ◽  
Isabela N. Rôças
Keyword(s):  
Inflammatory Diseases ◽  
Outer Membrane Proteins ◽  
Disease Process ◽  
Lipoteichoic Acid ◽  
Bacterial Pathogenesis ◽  
Apical Periodontitis ◽  
Related Factors ◽  
Therapeutic Measures ◽  
Root Canal System ◽  
Shock Proteins

Apical periodontitis is a group of inflammatory diseases caused by microorganisms (mainly bacteria) infecting the necrotic root canal system. The pathogenesis of different types of apical periodontitis and even the same type in different individuals is unlikely to follow a stereotyped fashion with regard to the involved bacterial mediators. Disease pathogenesis is rather complex and involves a multitude of bacteria- and host-related factors. This review article discusses the bacterial pathogenesis of acute and chronic apical periodontitis, with the main focus on the bacterial mediators conceivably involved in the different stages of the infectious process, including secreted products (enzymes, exotoxins, N-formyl-methionyl-leucyl-phenylalanine peptides, heat-shock proteins and metabolic end-products) and structural components (lipopolysaccharide, peptidoglycan, lipoteichoic acid, lipoproteins, fimbriae, flagella, outer membrane proteins and vesicles, DNA, and exopolysaccharides). Knowledge of the bacterial factors involved in the pathogenesis of apical periodontitis is important to the understanding of the disease process and to help establishing proper therapeutic measures to inactivate this bacterial "artillery".

scholarly journals Oral mucosal lesions in patients with pemphigus and pemphigoid skin diseases: a cross sectional study from southern India.

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Arvind Babu Rajendra Santosh ◽  
Venkat Ramana Reddy Baddam ◽  
Chigurupati Anuradha ◽  
Chandrashekar Poosarla
Keyword(s):  
Skin Diseases ◽  
Disease Process ◽  
Pemphigus Vulgaris ◽  
Diagnostic Procedures ◽  
Cross Sectional Study ◽  
Southern India ◽  
Cross Sectional ◽  
Autoimmune Blistering Disease ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Objective:To assess the prevalence of oral mucosal lesions in patients with pemphigus and pemphigoid diseases from Southern India. Design and Methods: A cross-sectional hospital based study was conducted from August 2010 to July 2011. Patients with confirmed pemphigus and pemphigoid skin disease were selected and informed to participate in the study. Oral examination of all participants were done to document site and type of oral manifestation and diagnostic procedures such as histopathological and Immunofluorescence methods were performed to confirm the diagnosis. Demographic details such as age, gender and occupation were also documented. The results of the study were analyzed by SPSS software version 19.0 (Armonk, NY) and presented as descriptive statistics. Results: Sixty percent of the patients exhibited oral mucosal manifestations. A higher female (86.66%) predilection of autoimmune blistering disease was observed in the study. A slightly higher number of pemphigoid patients (53.33%, 16 out of 30) were reported than pemphigus (46.66%, 14 out of 30 cases). The most common subtypes of pemphigus is Pemphigus vulgaris 71% (10 out of 14) among pemphigus, and bullous pemphigoid 87.5%(14 out of 16) among pemphigoid. Buccal mucosa (92.85%) is the most common site in pemphigus patients, where as hard palate (12.5%) is mostly commonly reported site in pemphigoid patients. Initial involvement of oral tissue in disease process was observed in 78.57% of pemphigus, and 12.5% of pemphigoid patients. Conclusion: Oral mucosal lesions are more frequently associated in pemphigus patients. Oral mucosal lesions are the initial site of disease process in pemphigus patients. The significance of diagnosis of oral lesions at earlier stage of disease, specifically pemphigus may help in early intervention of disease and help to reduce the morbidity and mortality state. The study emphasizes multidisciplinary approach in diagnosis and management of both pemphigus and pemphigoid.

Thrombotic microangiopathy: a case report and review of the literature.

1992 ◽  
Vol 3 (1) ◽  
pp. 35-41
Author(s):  
D L Sommerfeld ◽  
D C Brennan ◽  
J A Gordon
Keyword(s):  
Thrombotic Microangiopathy ◽  
Current Knowledge ◽  
Specific Treatment ◽  
Disease Process ◽  
Treatment Modalities ◽  
Blood Product Transfusion ◽  
High Morbidity ◽  
Plasma Therapy ◽  
Chronic Renal Impairment ◽  
Therapeutic Measures

Thrombotic microangiopathy most likely represents a spectrum of diseases consisting of multiple etiologies that has a final common pathway of multiorgan microvascular thrombosis. The variable responses to several different modes of therapy would suggest that more than one pathogenetic mechanism is involved. Untreated, it has been associated with very high morbidity and mortality rates. A poor understanding of the basic disease process has prevented specific treatment modalities, although early diagnosis and availability of dialysis and blood product transfusion services remain crucial. Several modes of therapy have been used to date, with plasma exchange being the most effective method studied and shown to improve survival. On the basis of current knowledge, this form of treatment should be instituted promptly in severe cases. Anecdotal reports of recovery with vincristine or IgG alone or with the use of IgG after the apparent failure of plasma therapy appear promising and deserve further investigation as initial therapeutic measures used in thrombotic microangiopathy. Although the majority of patients recover with normal renal function, those with severe thrombotic microangiopathy may heal through sclerosis with residual hypertension and chronic renal impairment requiring continual medical therapy.

Treatment of skin diseases with intravenous injections of CaC12 and NaBr solutions

1927 ◽  
Vol 23 (4) ◽  
pp. 458-461
Author(s):  
A. M. Okulov
Keyword(s):  
Pregnant Woman ◽  
Blood Serum ◽  
Skin Diseases ◽  
Severe Case ◽  
Great Success ◽  
Healthy Pregnant Woman ◽  
Intravenous Injections ◽  
Impetigo Herpetiformis ◽  
Therapeutic Measures

Therapy of skin diseases by intravenous injections of various drugs is not new and has its own history. At one time Mayer and Linser achieved great success in one severe case of dermatosis during pregnancy (impetigo herpetiformis) by intravenous injections of the blood serum of a healthy pregnant woman. Shortly thereafter, Linser was able to achieve the same success in some similar cases that did not respond to any other therapeutic measures.

A Retrospective Study of 12 Cases of Pyoderma Gangrenosum: Why We Should Avoid Surgical Intervention and What Therapy to Apply

2011 ◽  
Vol 77 (12) ◽  
pp. 1644-1649 ◽  
Author(s):  
Wioletta Barańska-Rybak ◽  
Monika Kakol ◽  
Matilda Naesstrom ◽  
Olivia Komorowska ◽  
Małgorzata Sokolowska-Wojdyło ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Skin Diseases ◽  
Surgical Intervention ◽  
Histopathological Examination ◽  
Case Series ◽  
Disease Process ◽  
Diagnosis And Treatment ◽  
Surgical Interventions ◽  
Case Series Study ◽  
Proper Diagnosis

Lesions of skin are ubiquitous in the medical field. The varying etiopathologies with similar presentation can pose a misleading picture, especially when faced with less common skin diseases. Furthermore, the misdiagnosis can cause detrimental effects on the patient's morbidity and mortality, which was seen in the case series study we performed on pyoderma gangrenosum. The history of 12 patients were analyzed in reference to the course of the disease, accompanying diseases, clinical picture, histopathological examination, surgical intervention before diagnosis, and treatment. Within this group of 12 patients, five were exposed to surgical interventions before diagnosis of pyoderma gangrenosum. The 5 patients were all exposed to prolonged aggravation of the disease process, followed by remission after proper diagnosis and treatment therapy. This study was done to improve the knowledge of surgeons about pyoderma gangrenosum considering the frequency of skin lesion cases in the surgical practice. Knowledge of the disease is essential to diagnose pyoderma gangrenosum in early stages to avoid interventions that may prolong or worsen the outcome. Surgical interventions in these patients should be avoided before proper diagnosis. The key to a better prognosis of pyoderma gangrenosum patients is often in the hands of surgeons.

Role of Virechana Purvaka Shamana Sneha with Rasayana drugs in the management of Psoriasis (Ekakustha).

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Sweety J. Ruparel ◽  
Sudhaben Vyas
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Skin Diseases ◽  
Social Stigma ◽  
Medical Science ◽  
Radical Cure ◽  
Temporary Relief ◽  
Therapeutic Measures ◽  
Chronic Course

Skin diseases are taken up as a social stigma, due to altered appearance. Psoriasis is one of the most repulsive skin diseases which may disturb patient’s life. It usually runs a chronic course with remission and exacerbations. As far as treatment is concerned modern medical science has number of therapeutic measures which provide temporary relief accompanied by side effects and which make the patients to take lifelong treatment. So it is a need to find out an effective radical cure for psoriasis through Ayurveda. According to Ayurveda all skin diseases are taken under generalized term Kustha. In present study psoriasis is considered as Ekakustha, one type of Kshudrakustha. As Shodhana therapy is essential in the management of all skin diseases, Virechana Karma was selected because it is the only procedure which acts upon all three Doshas and Raktadi Dushyas which are vitiated in Kustha. After Virechana Karma, Shamana treatment was also given to alleviate remaining Doshas and to continue the normal state of Dhatus. This clinical trial was conducted on total 13 patients of psoriasis (Ekakustha) to compare the effect of Virechana Purvaka Shamana with only Shamana. For Shamana purpose Shamana Sneha (Panchatikta Ghrita) along with some Rasayana drugs were used. Duration of Shamana treatment was 2 months in both groups. Patients of both the groups showed significant results. But Virechana Purvaka Shamana was found to be more effective than only Shamana.

A comparative clinical study of classical and non-classical Siravyadha in Vipadika

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Lalita Gaonkar ◽  
Gururaja H ◽  
Jeejo Chandran O
Keyword(s):  
Clinical Study ◽  
Effective Treatment ◽  
Severe Pain ◽  
Skin Diseases ◽  
Signs And Symptoms ◽  
Comparative Clinical Study ◽  
Therapeutic Measures ◽  
Effective Remedy

In Ayurveda all the skin diseases are described under single heading i.e. ‘Kushta’ which are further divided into Mahakushta and Kshudrakushta. Vipadika is among the 11 types of Kshudra Kushta involving Vata Kapha mentioned in classics characterized by ‘Panipada Sphutana’ (Fissures in Palms and Soles) and ‘Tivravedana’ (Severe Pain). On basis of its signs and symptoms it can be correlated with ‘Palmoplantar Psoriasis’. Kushtachikitsa is classified into Shodhanam, Shamanam and Nidanparivarjana amongst which Shodhana Chikitsa is of greater significance in skin diseases, and Raktamokshana is considered to be a shortest and effective treatment in the management of skin diseases. Siravyadha is a type of Panchashodhana described by Acharya’s as an effective remedy in number of disease conditions. Acharya Sushruta and Vagbhata has mentioned that Siravyadha is half treatment in Shalyatantra as Basti is the half treatment in Kayachikitsa. Diseases which do not get pacified so quickly by therapeutic measures like Snehana, Swedana etc. are pacified by Siravyadha.

scholarly journals Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Taha Baghbani ◽  
Hossein Nikzad ◽  
Javid Azadbakht ◽  
Fatemeh Izadpanah ◽  
Hamed Haddad Kashani
Keyword(s):  
Viral Infection ◽  
Viral Infections ◽  
Skin Diseases ◽  
Mammalian Species ◽  
Physical Damage ◽  
Entry Site ◽  
Current Health ◽  
Unicellular Eukaryotes ◽  
Different Types ◽  
Therapeutic Measures

AbstractAll of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and viruses, which in whole are called microbiota. These microorganisms have multiple different types of interaction with each other. A plethora of evidence suggests that they can regulate immune and digestive systems and also play roles in various diseases, such as mental, cardiovascular, metabolic and some skin diseases. In addition, they take-part in some current health problems like diabetes mellitus, obesity, cancers and infections. Viral infection is one of the most common and problematic health care issues, particularly in recent years that pandemics like SARS and COVID-19 caused a lot of financial and physical damage to the world. There are plenty of articles investigating the interaction between microbiota and infectious diseases. We focused on stimulatory to suppressive effects of microbiota on viral infections, hoping to find a solution to overcome this current pandemic. Then we reviewed mechanistically the effects of both microbiota and probiotics on most of the viruses. But unlike previous studies which concentrated on intestinal microbiota and infection, our focus is on respiratory system’s microbiota and respiratory viral infection, bearing in mind that respiratory system is a proper entry site and residence for viruses, and whereby infection, can lead to asymptomatic, mild, self-limiting, severe or even fatal infection. Finally, we overgeneralize the effects of microbiota on COVID-19 infection. In addition, we reviewed the articles about effects of the microbiota on coronaviruses and suggest some new therapeutic measures.

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